全文获取类型
收费全文 | 138篇 |
免费 | 4篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 12篇 |
基础医学 | 17篇 |
口腔科学 | 3篇 |
临床医学 | 9篇 |
内科学 | 31篇 |
皮肤病学 | 5篇 |
神经病学 | 22篇 |
特种医学 | 2篇 |
外科学 | 8篇 |
综合类 | 1篇 |
预防医学 | 11篇 |
眼科学 | 1篇 |
药学 | 12篇 |
肿瘤学 | 9篇 |
出版年
2024年 | 1篇 |
2022年 | 4篇 |
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2018年 | 4篇 |
2017年 | 5篇 |
2016年 | 5篇 |
2015年 | 1篇 |
2014年 | 10篇 |
2013年 | 13篇 |
2012年 | 10篇 |
2011年 | 8篇 |
2010年 | 4篇 |
2009年 | 7篇 |
2008年 | 10篇 |
2007年 | 8篇 |
2006年 | 8篇 |
2005年 | 10篇 |
2004年 | 5篇 |
2003年 | 2篇 |
2002年 | 6篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1997年 | 3篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1990年 | 1篇 |
排序方式: 共有144条查询结果,搜索用时 15 毫秒
91.
Juha E. Peltonen Simo Taimela Minna Erkintalo Jouko J. Salminen Airi Oksanen Urho M. Kujala 《European journal of applied physiology》1997,77(1-2):66-71
The association between physical training, low back extensor (erector spinae plus multifidus muscles) and psoas muscle cross-sectional areas (CSA) and strength characteristics of trunk extension and flexion were studied in adolescent girls. A group of athletes (n=49) (age range 13.7–16.3 years) consisting of gymnasts, figure skaters and ballet dancers was age-matched with non-athletes (n=17) who acted as a sedentary control group. The CSA of psoas muscles and multifidus plus erector spinae muscles were measured from lumbar axial images by magnetic resonance imaging. Maximal trunk extension and flexion forces were measured in a standing position using a dynamometer and trunk musculature endurance was evaluated using static holding tests. When CSA were adjusted with body mass, the athletes showed significantly greater CSA in both muscles studied (psoas P?0.001; erector spinae plus multifidus P?0.05) than the non-athletes. The athletes also had a greater absolute psoas muscle CSA (P?0.01) and trunk flexion force (P?0.01) compared to the controls. When the forces were expressed relative to body mass, the athletes were superior both in trunk flexion (P?0.001) and extension (P?0.001). There was a significant correlation between muscle CSA and strength parameters, but the force per muscle CSA did not differ significantly between the athletes and the non-athletes. In addition, the athletes showed a better body mass adjusted muscle endurance in trunk flexion (P?0.05) than the non-athletes. Our study indicated that regular physical training enhances trunk musculature hypertrophy, force and endurance in adolescent girls, and that there is an association between muscle CSA and strength parameters. 相似文献
92.
Airi?Nishimi Takeo?IsozakiEmail author Shinichiro?Nishimi Sho?Ishii Takahiro?Tokunaga Hidekazu?Furuya Kuninobu?Wakabayashi Tsuyoshi?Kasama 《Clinical rheumatology》2018,37(4):1017-1024
The “A disintegrin and metalloprotease” (ADAM) family is thought to play an important role in tissue destruction and inflammatory reactions. ADAM-17 was first described as the protease responsible for tumor necrosis factor (TNF)-α shedding. Here, we have shown the expression of ADAM-17 in inflammatory myopathy and demonstrated the role of inflammation in interstitial lung diseases (ILD). ADAM-17 in inflammatory myopathy serum [polymyositis (n?=?26), dermatomyositis (n?=?34), and clinically amyopathic dermatomyositis (n?=?10)] and healthy control (n?=?19) was measured using enzyme-linked immunosorbent assay. The relationship between ADAM-17 and clinical data was examined. Finally, we performed immunohistological analysis to investigate the expression of ADAM-17 on the muscles of the inflammatory myopathy patients. ADAM-17 in inflammatory myopathy was significantly higher than that in healthy control (mean ± SEM, 1048?±?312 and 36?±?18 pg/ml, respectively; p?<?0.05). ADAM-17 in post-treatment with corticosteroid and/or immunosuppressant serum was significantly decreased compared with that in pre-treatment serum (1465?±?562 and 1059?±?503 pg/ml, respectively; p?<?0.01). ADAM-17 was significantly positively correlated with fractalkine/CX3CL1 and CXCL16. In addition, ADAM-17 in inflammatory myopathy with ILD patients (n?=?46) was significantly higher than that in non-ILD patients (n?=?24) (1379?±?454 and 413?±?226 pg/ml, respectively; p?<?0.05). We found the expression of ADAM-17 on muscle biopsy tissue. ADAM-17 is expressed in inflammatory myopathies especially ILD, suggesting that ADAM-17 plays a role in lung fibrosis. ADAM-17 may be a potential target in inflammatory myopathies with ILD. 相似文献
93.
Pádraig Cotter Michael Kaess Paul Corcoran Peter Parzer Romuald Brunner Helen Keeley Vladimir Carli Camilla Wasserman Christina Hoven Marco Sarchiapone Alan Apter Judit Balazs Julio Bobes Doina Cosman Christian Haring Jean-Pierre Kahn Franz Resch Vita Postuvan Airi Värnik Danuta Wasserman 《Social psychiatry and psychiatric epidemiology》2015,50(6):973-982
94.
Eisuke Amiya Nobukazu Ishizaka Airi Watanabe Yoko Endo Rei Itou Shigetaka Yoshida Masahumi Nangaku Ryozo Nagai 《Circulation journal》2005,69(6):760-762
A 66-year old man, who had been diagnosed with dilated cardiomyopathy and felt a progressive shortness of breath and fatigability, was admitted to hospital. Computed tomography showed a thickening of the aortic wall from the aortic arch to the aortic bifurcation, as well as mild pleural and pericardial effusion. Intravenous pyelography showed severe ureteral stenosis, along with hydronephrosis, of the left side. There was a marked increase in C-reactive protein and the erythrocyte sedimentation rate, but the serology for connective tissue disease and perinuclear antineutrophil cytoplasmic antibodies was negative. Retroperitoneal fibrosis (RPF) with intrathoracic extension was diagnosed. After confirming the absence of malignant disease, an oral predonisolone treatment of 30 mg/day was started, and this ameliorated the ureteral obstruction, aortic wall thickening and pericardial effusion. The patient had been taking 300 mg of loxoprofen sodium for headaches every day for 16 years. The relationship between loxoprofen, cardiomyopathy and RPF remains unclear. There is a possibility of RPF in the patients with a thickening of thoracic aortic wall, as in this case. 相似文献
95.
96.
Background
Vaccination is an effective strategy to prevent influenza. This observer-blind, randomized study in children 10–17 years of age assessed whether the hemagglutination inhibition (HI) antibody responses elicited by H1N1/2009 vaccines adjuvanted with AS03 (an adjuvant system containing α-tocopherol and squalene in an oil-in-water emulsion) or without adjuvant, met the European regulatory immunogenicity criteria at Days 21 and 182.Methods
Three hundred and ten healthy children were randomized (3:3:3:5) to receive one dose of 3.75 μg hemagglutinin (HA) AS03A-adjuvanted vaccine, one or two doses of 1.9 μg HA AS03B-adjuvanted vaccine, or one dose of 15 μg HA pandemic vaccine. All children received a booster dose of the allocated vaccine at Day 182. Serum samples were tested for HI antibody response at Days 21, 42, 182 and 189.Results
All vaccination regimens elicited HI antibody responses that met the European regulatory criteria at Days 21 and 42. HI antibody responses fulfilling European regulatory criteria were still observed six months after the first vaccine dose in all study vaccines groups. Two doses of 1.9 μg HA AS03B-adjuvanted vaccine elicited the strongest HI antibody response throughout the study. The non-adjuvanted 15 μg HA vaccine elicited a lower HI antibody response than the AS03-adjuvanted vaccines. At Day 189, the European regulatory criteria were met for all vaccines with baseline HI antibody titers as reference. An anamnestic response for all vaccines was suggested at Day 189, based on the rapid increase in HI antibody geometric mean titers (1.5–2.5-fold increase). Injection site reactogenicity was higher following the AS03-adjuvanted vaccines compared with the non-adjuvanted vaccine. No safety concerns were identified for any study vaccine.Conclusion
All study vaccines elicited HI antibody responses that persisted at purported protective levels through six months after vaccination and fulfilled the European regulatory criteria. 相似文献97.
Yoshihide Miura Kouhei Kamiya Kaoru Kanazawa Masayuki Okada Masaki Nakane Airi Kumasaka Kaneyuki Kawamae 《Journal of anesthesia》2012,26(5):721-727
Purpose
Studies comparing the recovery profiles of isoflurane- and propofol-based anesthesia for major intracranial surgery have reported contradictory results. The aim of our study was to clarify the emergence status in both regimens by investigating uniformly managed neuroanesthesia cases.Methods
The anesthesia database at Yamagata University Hospital covering the period 2002–2005 was retrospectively investigated for adult patients who underwent craniotomy for primary brain tumor excision. General anesthesia was provided by an isoflurane- (ISO group) or propofol-based (PROP group) regimen. Times to extubation and operating room (OR) discharge, perioperative consciousness levels, and perioperative variables were compared.Results
Of the 202 surgeries performed during the study period, 77 and 82 patients were anesthetized with isoflurane and propofol, respectively. Demographic data were comparable between the two groups, although the American Society of Anesthesiology grade was worse in the PROP group. Extubation times [39.5?±?14.6?min (ISO) vs. 29.5?±?14.9?min (PROP); P?<?0.001] and OR discharge times [67.2?±?18.0 (ISO) vs. 53.9?±?17.6?min (PROP); P?<?0.001] were significantly shorter in the PROP, with significantly better immediate consciousness levels. The differences in levels of consciousness persisted for several hours postoperatively. PROP patients had significantly higher urine outputs and lower body temperatures during anesthesia. The incidences of shivering, nausea, vomiting, and convulsions were not significantly different between the groups. The time to discharge was similar between the groups.Conclusions
Propofol was associated with a better recovery profile and neurological condition than isoflurane, as indicated by shorter extubation and OR discharge times and better postoperative consciousness. 相似文献98.
Nishimi Airi Isozaki Takeo Nishimi Shinichiro Ishii Sho Tokunaga Takahiro Furuya Hidekazu Wakabayashi Kuninobu Kasama Tsuyoshi 《Clinical rheumatology》2018,37(4):1025-1026
Clinical Rheumatology - The original version of this article, unfortunately, contained errors. Figure citation, caption, image and updated sentence in the Result section are now presented correctly... 相似文献
99.
Takahiro Akimoto Shohei Kobayashi Airi Nakayama Anna Isobe Koudai Abe Taichi Hatakeyama Ryo Ohta Rie Yanagisawa Eiko Koike Noriyuki Suzuki Maiko Kawaguchi 《Journal of applied toxicology : JAT》2022,42(9):1503-1509
There is increasing concern about multiple high concentration exposure to toxins in disaster and emergency situations. However, conventional toxicology testing methods may not adequately address these situations. Thus, we assessed whether the toxic effects of exposure in the adulthood differ depending on the presence or absence of neonatal exposure to Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) in male rats to investigate the effects of exposure history of chemicals. In the neonatal stage [postnatal days (PNDs) 1–7], animals were treated with either sesame oil (5 ml/kg/day) as a control or TDCIPP (250 mg/kg/day) dissolved in sesame oil. In adulthood (PND 101–107), animals were treated with either sesame oil (5 ml/kg/day) or TDCIPP (650 mg/kg/day). One day after the final administration, dissection was performed, and body and organ weight, hematology, blood biochemistry, and histopathology were examined. The results demonstrated that the toxic effects of TDCIPP exposure in adulthood on adrenal gland size, serum iron content, and unsaturated iron binding capacity were enhanced by TDCIPP exposure in the neonatal stage. From these findings, it was indicated that the toxic effects of TDCIPP exposure in the adult stage are affected by pediatric exposure. These results suggest that the toxic effects of high-dose and long-term unsteady exposure to chemicals in large-scale disasters may change based on the exposure history of chemicals. 相似文献
100.