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91.
OHTA MITSUO; HARA NOBUYUKI; ICHINOSE YUKITO; MOTOHIRO AKIRA; TAKEO SADANORI; MIYAKE JUN 《Japanese journal of clinical oncology》1986,16(3):289-296
To assess the role of surgical resection in the management ofsmall cell carcinoma of the lung, experience with 118 patientswho were treated between 1973 and 1985 was reviewed. Twenty-fivepatients underwent surgical resection followed by combinationchemotherapy in all except one. The remaining 93 pa tients weretreated by combined chemotherapy and radiation therapy. The 5-year survival rate for patients with stage I disease undergoingsurgical resection was 50.8%. For all 25 patients operated on,the 5-year survival rate was 30.7%. In the patients not operated on, only those with complete responsehad long-term survival, for whom the 5-year survival rate was11.9% We consider that surgical resection is definitely indicatedin patients with stage I disease. If the response to initialchemotherapy is very good, patients with stage 11 or T3N0M0disease also probably should receive resection. Patients withN2 disease are not candidates for resection, unless distantmetastases are controlled completely by intensive chemotherapy. 相似文献
92.
Targeted Disruption of the IL-6 Related Genes: gp130 and NF-IL-6 总被引:5,自引:0,他引:5
SHIZUO AKIRA KANJI YOSHIDA TAKASHI TANAKA TETSUYA TAGA TADAMITSU KISHIMOTO 《Immunological reviews》1995,148(1):221-253
93.
OSAMU UKIMURA AKIHIRO KAWAUCHI AKIRA FUJITO YOICHI MIZUTANI KOJI OKIHARA KAZUYA MIKAMI JINTETSU SOH TERUKAZU NAKAMURA HIROYUKI NAKANISHI SO USHIJIMA TSUNEHARU MIKI 《International journal of urology》2004,11(12):1051-1057
OBJECTIVE: Although radio-frequency ablation (RFA) has been recently applied as a minimally invasive treatment option for renal cell carcinoma (RCC), indication of this modality remains a critical issue due to the lack of complete tumor destruction as well as the uncertainty of its long-term efficacy. We report the efficacy of RFA for nine carefully selected patients with RCC who had significant reason to avoid invasive surgical treatment under general anesthesia. METHODS: Radio-frequency ablation was performed under epidural or local anesthesia by ultrasound or computed tomography (CT) guidance in nine patients with biopsy proven RCC (mean diameter, 38 mm; range, 20-53 mm), who were at significant operative or anesthetic risk for invasive surgery. Follow-up enhanced CT scans or magnetic resonance images were evaluated every 3-6 months and an evaluation of metastasis was performed every 6 months. RESULTS: At a mean follow-up of 17 months, seven (78%) of the nine patients with renal tumor showed no tumor enhancement. The renal function of all patients was well preserved. All patients were able to continue undergoing their respective treatments for active diseases in other organs in parallel to the RFA treatment. No distant metastasis, urine leakage were reported and one case of temporary hematuria and one case of peri-renal hemorrhage not requiring blood transfusion were encountered. Intra-operative ultrasonography was useful in the real-time monitoring of the minimally excessive extension of ablation into the normal parenchyma. CONCLUSION: Radio-frequency ablation appears to be an effective and safe minimally invasive therapeutic option for selected patients with RCC who have reason to avoid invasive surgery under general anesthesia. 相似文献
94.
95.
Histological findings in asymptomatic hepatitis C virus carriers 总被引:1,自引:0,他引:1
TOSHINORI KODAMA TOMOHIRO TAMAKI SHIGEO KATABAMI AKIO KATAMUMA KENTARO YAMASHITA NAOKI AZUMA KEIICHI KAMIJO HIROSHI KINOSHITA AKIRA YACHI 《Journal of gastroenterology and hepatology》1993,8(5):403-405
There is controversy about clinical management of individuals who persistently have hepatitis C virus antibodies (HCVAb) but who have no symptoms or signs of liver disease. Liver biopsy samples were taken from 15 individuals, all of whom had normal alanine aminotransferase (ALT) levels, to determine the prevalence of liver disease and whether HCVAb and HCV-RNA correlate with histological findings. Eleven patients with hepatitis C viremia had histological evidence of chronic hepatitis on biopsy. On the other hand, four HCV-RNA-negative individuals had almost normal liver histology. These findings indicate that serum HCV-RNA is a sensitive and specific marker of liver disease in HCVAb-positive subjects, independent of ALT levels. Furthermore, these results suggest that there are very few histologically healthy carriers of HCV among HCV-RNA-positive individuals. 相似文献
96.
Laparoscopic adrenalectomy in patients with large adrenal tumors 总被引:4,自引:0,他引:4
YUKIO NAYA HIROYOSHI SUZUKI AKIRA KOMIYA MAKI NAGATA TOYOFUSA TOBE TAKESHI UEDA TOMOHIKO ICHIKAWA TATSUO IGARASHI KUNIO YAMAGUCHI HARUO ITO 《International journal of urology》2005,12(2):134-139
OBJECTIVES: The maximum size of adrenal tumors that should be removed by laparoscopic adrenalectomy is controversial. We conducted a retrospective comparison of the results of laparoscopic adrenalectomy between patients with adrenal tumors > or =6 cm ('large tumors') and patients with adrenal tumors <6 cm ('small tumors'). METHODS: The participants in the study were 16 patients with large tumors and 111 patients with small tumors. The patients comprised 59 men and 68 women (mean age, 49.0 years; age range, 23-79) with varying diagnoses. Of the 16 patients with large tumors, five had Cushing's syndrome, four had pheochromocytomas, six had a non-functional tumor and one had malignant lymphoma. Adrenal tumors were confirmed by hormonal assays, biochemical tests and computed tomography. Of the 16 large tumors, five tumors were on the right and 11 were on the left. RESULTS: We found no significant differences in general demographic parameters between patients with large and small tumors. The mean duration of surgery was not significantly different between two groups. (large tumors, 210 min; small tumors,175 min). The mean volume of blood loss was 212 mL for large tumors and 30 mL for small tumors (P < 0.001, significant difference). There was no significant difference in time until walking, duration of hospitalization or number of using analgesics used. The time to first oral intake of group 1 (<6 cm) was significantly shorter than group 2 (> or =6 cm). Tumor size (> or =7.5 cm) was an independent predictor of a longer operation and greater blood loss in large tumors. CONCLUSIONS: Laparoscopic adrenalectomy for large tumors was safe and minimally invasive. 相似文献
97.
HIROSHI FUKUI MUNESUKE MATSUMOTO SHIGENOBU TSUJITA AKIRA TAKAYA HIDEYUKI KOJIMA MASAHIKO MATSUMURA TADASU TSUJII 《Journal of gastroenterology and hepatology》1994,9(6):582-586
Plasma endotoxin levels in 12 cirrhotics with bleeding from oesophageal varices and 50 cirrhotics without bleeding were measured by the chromogenic assay after the pretreatment of sample by perchloric acid (HClO4) and triethylamine. Endotoxin in cirrhotics with bleeding from varices was significantly higher than those without bleeding. In patients with bleeding, endotoxin increased for 3 days after the bleeding, first in the supernatant fraction and then in the precipitate fraction by HClO4 treatment. Peak plasma α1-acid glycoprotein and haptoglobin were observed 3 days after the bleeding. Alpha 1-antitrypsin gradually increased for 14 days. Transferrin did not markedly change. The endotoxin-binding capacity of transferrin and α1-acid glycoprotein increased immediately after bleeding and thereafter decreased, but that of α1-antitrypsin tended to increase in the recovery period. In summary, the plasma endotoxin concentration and endotoxin-binding capacity of α1-acid glycoprotein and transferrin were shown to have increased after bleeding from varices by this new method. There may be a close relationship between endotoxaemia and acute phase reaction in this situation. 相似文献
98.
Neonatal erythema infectiosum 总被引:1,自引:0,他引:1
HIDEKI MINOWA TOSHIYA NISHIKUBO YUMIKO UCHIDA KEIJI NOGAMI CHIKAKO YAMASHITA HIDEKAZU KAMITSUJU YUKIHIRO TAKAHASHI AKIRA YOSHIOKA 《Pediatrics international》1998,40(1):88-90
A report is presented of a patient with neonatal erythema infectiosum who developed petechiae, transient thrombocytopenia and transient cardiac failure due to transplacental transmission of human parvovirus B19 (HPV B19) infection. It is suggested that the thrombocytopenia was caused by platelet-associated IgG produced by the patient, and that the cardiac failure may have been caused by direct entry of HPV B19 into the cardiac tissue. 相似文献
99.
HARUMI ARAKI NAOKO OGAKE SHINAZBURO MINAMI YASUO WATANABE HIROKAZU NARITA IKUMI TAMAI AKIRA TSUJI 《The Journal of pharmacy and pharmacology》1997,49(11):1141-1144
Muscle microdialysis has been used to determine the unbound concentrations of the fluoroquinolones, pazufloxacin and ofloxacin, in tissue interstitial fluids (Cisf, u) of rats under steady state conditions. Cisf, u was estimated from the concentration in dialysate and the in-vitro permeability rate constant by the extrapolation method based on the clearance concept. Paper disks were inserted under the abdominal skin of rats, and the drug concentrations in the fluids penetrating into the disks (Cdisk) were measured and compared with Cisf, u. The Cisf, u of pazufloxacin and ofloxacin in muscle were close to their unbound concentrations in the venous plasma; these were 75.3% and 77.1%, respectively, of the total concentrations in plasma at the steady state. The Cdisk of pazufloxacin and ofloxacin were also close to their Cisf, u. These results indicate that the unbound concentrations of the fluoroquinolones in the tissue interstitial fluids were the same as those in the venous plasma. The disk insertion technique seems to be useful for evaluating drug concentrations in tissue interstitial fluid. 相似文献
100.