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??Efficacy of FOLFOX4 regimen systemic chemotherapy in treating advanced hepatocellular carcinoma: An analysis of 22 cases YIN Xiao-yu*??CHEN Jie??PENG Jian-xin??et al. *Department of Hepatobiliary Surgery??the First Affiliated Hospital of Sun Yat-sen University??Guangzhou 510080??China
Corresponding author??YIN Xiao-yu??E-mail??yinxy@21cn.com
Abstract Objective To evaluate the efficacy of FOLFOX4 regimen systemic chemotherapy in treating advanced hepatocellular carcinoma (HCC). Methods The clinical data of 22 cases of advanced HCC were treated by FOLFOX4 regimen systemic chemotherapy between July 2007 and July 2013 in the First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. The chemotherapy was given each two weeks??with a maximum of 8 cycles. The therapeutic responses were evaluated each 3 cycles and end of treatment. Results A total of 85 cycles were administered in 22 cases??with a mean of ??3.7±2.0?? cycles /case. There were no complete response??5 partial responses??5 static diseases and 12 progressive diseases. The objective response rate was 22.7% (5/22)??and disease control rate was 45.4% (10/22)??with a one-year survival rate of 12.1% and median survival time of 5.8 months in the follow up of 2-34 ??8.5±1.9??months . In 10 cases of disease control after chemotherapy??the median survival time reached up to 9.5 months. Conclusion FOLFOX4 regimen systemic chemotherapy is effective in part of advanced HCC??and represented as an effective modality.     

抗菌肽Maximin衍生物的体外杀精效果研究

目的比较抗菌肽Maximin衍生物(M1~M19)的体外杀精效果和细胞毒性作用,筛选有进一步研究价值的候选体外杀精剂。方法利用Sander-Cramer方法评价抗菌肽的体外杀精效果;CCK-8试剂盒测定抗菌肽对Hela-229的细胞毒性,筛选出具有较强杀精作用和低细胞毒性的抗菌肽。结果 19种抗菌肽衍生物中,M1、M7、M11、M15和M17五种抗菌肽在2 000mg/L时均能完全制动精子,其中100%制动精子的最低浓度EC100分别是:M7=M11=2 000mg/L,M1=M15=M17=1 500mg/L;利用Hela-229细胞分析细胞毒性时,M11的细胞毒性明显低于其他4种抗菌肽,表现出较高的安全性。结论对19种抗菌肽衍生物的体外研究表明,抗菌肽M11具有较强的杀精作用,且细胞毒性低,有望成为体外杀精剂的候选药物。     

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??Abstract?? Objective To study balloon dilatation with cryotherapy under bronchoscope for subglottic stenosis in infants and young children??and to explore the efficacy of this new technology??the timing of treatment and safety. MethodFrom July 2009 to May 2014 in 28 SGS cases aged from 1 month to 3 years?? bronchoscopic balloon dilatation treatment with CO2 cryotherapy was performed?? and different types of SGS treated by minimal invasi were assessed regarding efficacy, complications and outcome. Results The infant SGS were divided into ??°~??° by severity?? and soft membrane SGS and scarring SGS by the causes of stenosis. ??° SGS included 16 cases, in which 8 cases soft membrane SGS were treated by balloon dilatation effectively?? 9 cases after combined treatment; in scarring SGS balloon dilatation was effective in 1 case?? 4 cases after combined therapy; ??° SGS included 8 cases?? soft membrane SGS were treated effectively in 2 cases?? 4 cases after combined treatment; in scarring SGS balloon dilatation was effective in 1 case?? 2 cases after combined therapy; ?? °SGS included 4 cases?? 1 case of soft membrane SGS and 1 case of scarring SGS responded well to integrated treatment .Conclusion MSCT and bronchoscopy assessment is used in grading the extent and causes of stratification in infants with subglottic stenosis?? and then we can select the appropriate treatment programs to improve the prognosis of the disease and improve life quality of SGS children.     

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??Abstract??The purpose of the present study was to show the different choices of periodontal surgeries in resolving various clinical problems. There were both demands of restoration in bilateral posterior areas of the patient??but their remaining of local dental tissue was different. In order to immediately restore the function and esthetic of the patient's dentition??the crown-lengthening surgery was applied on the side of more dental tissue available??the tooth was extracted on the other side of less dental tissue available and cureless apical lesion??also??implant surgery was applied electively. Soft and hard tissue augmentation was finished in implantation synchronously. The effect of final restorations was good and the patient was satisfied. The periodontal surgery played the key role in multidisciplinary treatment??therefore??its indications should be carefully and comprehensively chosen in overall treatment design.     

CXCL12/CXCR4信号通路与缺血性脑卒中新进展

缺血性脑卒中是一种严重威胁人类健康和生命的疾病,致残率和致死率较高。缺血性脑卒中会导致中枢神经系统损伤和功能障碍。缺血性脑卒中发生后,内皮祖细胞参与修复血管内皮和神经损伤,在这一过程中CXCL12/CXCR4 信号通路起着重要的作用。本文将对CXCL12/CXCR4 信号通路与缺血性脑卒中新进展进行综述。     

肝性脑病误诊1例报道及文献复习

探讨肝性脑病(HE)的临床特征及误诊原因。对我科收治的1例HE误诊病例资料进行回顾性分析。本例患者主因乏力伴纳差1年,加重2个月,意识不清约2 h就诊,经过详细询问病史,完善有特征性意义的辅助检查而确诊,因患者病情重、家庭经济条件差,家属放弃治疗。凡以性格改变或行为失常、睡眠障碍等为突出表现的肝病患者,应警惕HE的可能。加强认识、提高诊治水平是尽早确诊、改善预后的关键。     

不同产前筛查方案对胎儿染色体异常检出效率的比较

目的 探讨不同产前筛查方案对胎儿染色体异常的检出效率.方法 应用时间分辨免疫荧光法对24986例孕妇进行母体血清学二联筛查,根据风险值及后续的检查方案不同将人群分为高风险直接进行羊水穿刺组(A1组)、高风险行无创产前检测(non-invasive prenatal testing,NIPT)组(A2组)、临界风险进行超...     

肾移植术后卡氏肺孢子虫肺炎29例临床分析

目的 探讨肾移植术后发生卡氏肺孢子虫肺炎(PCP)的病因、特点及诊疗方案.方法 对在我院诊治的29例肾移植术后卡氏肺孢子虫肺炎患者的临床资料进行回顾性分析.结果 29例肾移植术后PCP患者,其中14例发展至急性呼吸窘迫综合征,28例痊愈,1例患者合并巨细胞病毒感染,并发心衰而死亡.结论 PCP多发生在移植术后3～6月,病情进展快,凶险,应以预防为主,个体化合理使用免疫抑制剂是关键;一旦发生,尽早诊断,合理治疗:尽早、足量给予复方磺胺甲恶唑、减少免疫抑制剂,支持治疗,必要时果断使用呼吸机支持是救治成功的关键.     

活体亲属供肾移植12例

目的 总结亲属活体肾移植的临床应用经验.方法 回顾分析12例亲属活体肾移植其临床资料.结果 供者无外科并发症发生,恢复良好.12例受者中,1例高致敏受者(群体反应性抗体,PRA 100%)成功接受移植.1例发生急性排斥1次,逆转治疗后肾功能良好.1例由于擅自停用免疫抑制剂量而于移植后1年移植肾失功,余11例肾功能一直良好.结论 亲属活体供肾移植效果好,安全可行.