Association between p53 Pro72Arg polymorphism and prostate cancer risk:a meta-analysis

The tumor suppressor gene p53 appears to be important in the development of many human cancers, such as prostate cancer. The association of p53 codon72 polymorphism with prostate cancer has been widely reported; however, the results are inconsistent. To derive a more precise estimation of this relationship, we performed an updated meta-analysis from 10 case-control studies. We conducted a search in the PubMed database without a language limitation, covering all papers published until July 2010. Risk ratios ...     

��ѧ�����ƽ���֢���˸�������ϵ�о�

??Methods    The modified Corah’s Dental Anxiety Scale and Eysenck Personality Questionaire were conducted on 1200 college students in Fuzhou. The data was analyzed by software SPSS17.0. Results    The prevalence rate of dental anxiety of introverted- unstable personality??65.91%?? was significantly higher??P??0.05?? than the other three and it was not different among introverted-stable personality??54.3%????extroverted-stable personality??46.99%??and extroverted-unstable personality??52.96%????P??0.05??. The score of the modified Corah’s Dental Anxiety Scale of introverted-unstable personality??12.07±3.454??score was also significantly higher than introverted-stable personality??10.86±3.225??score??extroverted-stable personality??10.30±3.374??score and extroverted-unstable personality??10.91±3.245??score??P??0.05??.There was no difference in other types of personality characteristics??P??0.05????except extroverted-stable and extroverted-unstable personality??P??0.05??. Conclusion    People who have introverted-unstable personality are more likely to suffer from dental anxiety and the level of dental anxiety is more serious.     

远端胃大部切除术后早期贲门完全性梗阻1例报告

正术后早期出现贲门梗阻是胃癌远端胃大部切除术后一种少见而又非常严重的手术并发症。其发生的原因不明。表现为严重的进食后呕吐、频发吐口水、滴水难进,甚至危及生命。中南大学湘雅三医院诊治1例远端胃大部切除术后8 d进食流质食物后出院,因出现贲门梗阻返院治疗的病例。现报告如下。     

��Ĥ���������н����������⶯��������̽�֣���3�����棩

??Without restruction followed the external iliac artery resection for en bloc excision of huge retroperitoneal sarcoma: A report of three cases ZHENG Jia-jia*??YANG Yu??TONG Han-xing??et al. *Department of General Surgery??Zhongshan Hospital, Fudan University??Shanghai 200032??China
Corresponding author??LU Wei-qi??E-mail: lu.weiqi@zs-hospital.sh.cn
Abstract Objective To discuss the experience of dealing with external iliac artery which involved by retroperitoneal sarcoma. Methods The clinical data of 3 patients treated in Department of General Surgery??Zhongshan Hospital, Fudan University from November 2012 to November 2014 were analyzed retrospectively. The patients underwent en bloc excision of retroperitoneal sarcoma involved external iliac artery. One patient was found external iliac arterial occlusion during the operation. Two patients underwent emergency operations because of rupture of arterial anastomoses after vascular reconstruction in previous operations. All patients ligated unilateral external iliac arteries finally. Results Postoperative pathological examinations showed that, in all three patients, tumors invaded adipose tissue lateral to the arteries, and one of the three had vascular atresia by thrombus. One patient had calf muscle pain after operation, and was cured by vasodilator drugs 1 months later. Another two patients had no symptoms of lower limb ischemia or claudication.Two weeks after operations, CTA were conducted in both patients, and showed discontinuities of left external iliac arteries, but the blood flows in femoral arteries and their distal branches were normal. Many collateral vessels could be seen around the artery interruption. Follow-up of 6 months after operations showed that there was no influence in blood supplies of the lower limbs among all three patients. Conclusion It is generally agreed that the risk of artery ligation is high. But in certain conditions??collateral circulation may avoid those disastrous consequences.     

小潮气量通气治疗小儿急性呼吸窘迫综合征临床研究

目的 观察小潮气量通气治疗小儿急性呼吸窘迫综合征(ARDS)的疗效.方法 选择本院2008年1月至2011年12月本院PICU收治需支持通气的ARDS患儿44例为研究对象,将患者分为2组,对照组(20例)机械通气采用常规潮气量(10～12 ml/kg);观察组(24例)机械通气采用小潮气量(6～8 ml/kg).上机后观察两组患儿24、48及72 h氧合改善及血气分析等指标变化,分析机械通气并发症及28 d病死率.结果 两组患儿上机前PaO2/FiO2值(104±23.6 vs 112 ±34.7)比较差异无统计学意义(P＞0.05);上机后24、48及72 h PaO2/Fi02、PaCO2两组比较差异均有统计学意义(t≥2.01,P＜0.05;t ≥2.74,P＜0.01);观察组气压伤低于对照组(x2 =6.97,P＜0.01);观察组病死率16.7％(4/24)低于对照组50％(10/20),其差异有统计学意义(x2=5.58,P＜0.05).结论 ARDS患儿采用小潮气量通气,能改善其氧和,且无血液动力学影响,亦可降低机械通气并发症及病死率,其疗效确切,值得临床推广应用.     

The acute structural changes of loaded articular cartilage following meniscectomy or ACL-transection

Objective Meniscectomy and anterior cruciate ligament (ACL) rupture have been identified as precursors of osteoarthrosis (OA) in clinical reviews and animal experiments. In this study, the acute effects of these injuries on articular cartilage matrix deformation, preserved in a loaded state using a cryopreservation technique, were studied by scanning electron microscopy (SEM).Method Whole knee joints from adult White New Zealand rabbits (N=87) were loaded ex vivo, using a simulated quadriceps pull under static and cyclic loading conditions, following medial meniscectomy or transection of the ACL. Specimens were plunge-frozen while under load, or following a recovery period, and prepared for SEM by cryofixation. Using SEM and photographic images, the medial tibial plateau cartilage was assessed both qualitatively and quantitatively.Results After meniscectomy, significantly increased bending and crimping of radial collagen fibers occurred with static loading. Compared to intact knees, the area of tibial cartilage showing an indentation was increased by 80% (P< 0.05), the articular cartilage thickness was significantly more reduced when under load (for high force long duration static loading, intact joints had 53%±3 reduction in cartilage thickness compared to 39%±4 after meniscectomy, P< 0.05), and it took nearly twice as long for the cartilage thickness to recover following loading. These post-meniscectomy differences were either not present or were minimal when the joint was allowed to extend when loaded. ACL-transection slightly increased collagen deformation in the deeper zones, but only with cyclic loading.Conclusion The findings indicate that, with static loading, significantly increased deformation of articular cartilage collagen structure can occur following meniscectomy, but is minimized by joint motion. This increased deformation may be relevant to the etiology and progression of joint degeneration.     

��������1����ͻ�����²�ͬ�ٴ�����������������ȱ�ݲ�3������

??Abstract?? Objective To investigate the different clinical and immune features of variable phenotypes of severe combined immunodeficiency caused by RAG 1 mutations.Methods From 2012.9 to 2013.04?? three patients were included in the study??and records of clinical details were reviewed. Results The phenotypes of three patients were typical SCID for patient 1??Omenn syndrome for patient 2 and atypical SCID complicated with recurrent autoimmune hemolytic anemia for patients 3??respectively.RAG 1 mutations were compound heterozygous allele 1??1870 C??T/Arg624Cys??allele 2??2005 G??A/Glu669Lys??allele 1 was published mutation??allele 2 was de novel mutation?? for patient 1??compound heterozygous allele 1??994 C??T/Arg332X??allele 2??1439 G??A/Ser480Asn??both mutations were de novel mutations??for patient 2??homozygous 2095 C??T/R699W for patient 3 and was published mutation. First two patients died soon after discharge.Patient 3 was treated for recurrent autoimmune hemolytic anemia in our ward.Conclusion RAG1 mutations can lead to variable SCID phenotypes.Patients with typical SCID and Omenn syndrome were with poor prognosis??which need transplantation treatment.     

Seroprevalence of syphilis among women attending urban antenatal clinics in Burkina Faso, 1995-8. The DITRAME Study Group. DIminunation de la TRAnsmission Mère-Enfant

OBJECTIVES: To describe annual trends in syphilis seroprevalence and to identify risk factors of syphilis among pregnant women receiving antenatal care in Bobo-Dioulasso, Burkina Faso. METHODS: Women were recruited between January 1995 and July 1998 in three antenatal clinics where counselling and HIV testing services had been established in the context of a trial evaluating a short course of zidovudine to reduce mother to child transmission of HIV (ANRS 049 trial). Sociodemographic variables were collected during HIV pretest counselling sessions. Syphilis diagnosis was considered when serum was positive with both rapid plasma reagin and Treponema pallidum haemagglutination assay (TPHA) tests. RESULTS: Overall, 10,980 pregnant women were screened. Syphilis seroprevalence was 0.24% (95% confidence interval (CI): 0.15-0.35) without changes over time. HIV prevalence was 8.8% (CI: 8.3-9.3). In a multivariable analysis, having casual sex partners (odds ratio (OR) = 4.48; CI: 1.62-12.38), being HIV seropositive (OR = 2.62; CI: 1.02-6.74), and being illiterate (OR = 3.78; CI: 1.24-11.48) were independent risk factors for syphilis infection. CONCLUSIONS: This study suggests low syphilis seroprevalence in this city of Burkina Faso. Sexually transmitted disease programmes should be reinforced to offer free access to syphilis screening and treatment in order to eliminate this disease, in coordination with HIV prevention and care.