先天性马蹄内翻足动物模型胚胎后肢(芽)评分系统的建立

Objective Quantification of the severity of congenital clubfoot is essential for its re-search and treatment. Up to date, no scoring system is available for hind limb bud development. In this study,a scoring system was established based on a murine model Methods Sixty female Wistar rats weighing 220～250 g were randomized into the six control groups and six experimental groups. Vaginal sperm plug detection day was considered to be day 0 of gestation. Hind limb buds from fetuses of E13, 14, 15,16,17 and 18 days were removed and processed. Results Morphogenetic differentiation changes were detected in the experimental groups. According the new scoring system, clubfoot-like deformity was present in 80.9% of the experimental fetuses. We were able to quantify the extent morphogenetic diffcrentiation of the hind limb accordingly. Conclusions Congenital clubfoot deformities begin at early developmental stage and become exaggerated as the fetuses mature. The scoring system can quantify the extent of congenital clubfoot deformity and facilitate its management.     

应用伤椎置钉固定治疗胸腰椎骨折35例体会

目的 分析和探讨经伤椎置钉固定治疗胸腰椎骨折的可行性、临床疗效及注意事项.方法 回顾性分析35例胸腰椎骨折患者的临床资料,采用经伤椎椎弓根钉固定的6钉固定术,分析术中出血量、手术时间、伤椎前缘高度、后凸Cobb角、内固定失败率、术后并发症等.结果 有2例伤椎置钉失败,其他病例伤椎置钉均顺利完成,螺钉位置及椎体复位满意,...     

先天性马蹄内翻足动物模型胚胎后肢(芽)评分系统的建立

Objective Quantification of the severity of congenital clubfoot is essential for its re-search and treatment. Up to date, no scoring system is available for hind limb bud development. In this study,a scoring system was established based on a murine model Methods Sixty female Wistar rats weighing 220～250 g were randomized into the six control groups and six experimental groups. Vaginal sperm plug detection day was considered to be day 0 of gestation. Hind limb buds from fetuses of E13, 14, 15,16,17 and 18 days were removed and processed. Results Morphogenetic differentiation changes were detected in the experimental groups. According the new scoring system, clubfoot-like deformity was present in 80.9% of the experimental fetuses. We were able to quantify the extent morphogenetic diffcrentiation of the hind limb accordingly. Conclusions Congenital clubfoot deformities begin at early developmental stage and become exaggerated as the fetuses mature. The scoring system can quantify the extent of congenital clubfoot deformity and facilitate its management.     

介入肿瘤摘除术联合经皮椎体成形术治疗脊柱 转移性肿瘤椎体压缩性骨折的 疗效及安全性评价

目的 探讨介入肿瘤摘除术（ITR）联合经皮椎体成形术（PVP）治疗肿瘤椎体压缩性骨折的疗效 及其安全性。方法 选取2010 年10 月至2014 年10 月揭阳市人民医院接诊治疗的脊柱转移性肿瘤椎体压缩性 骨折患者76 例为研究对象,依据治疗方法的不同分为PVP 联合ITR 组37 例（48 椎）和PVP 组39 例（52 椎）。 术后3 d 行脊柱CT,X 射线检查骨水泥渗漏发生情况。依据两组患者术前24 h 及术后24 h、1、3、6、12 及24 个月随访中疼痛情况评价治疗效果,依据两组术中骨水泥注射量、住院时间及并发症的发生情况评价其安全性。 结果 76 例（100 椎）患者均完成手术,未发生出血、感染、心肺功能障碍等并发症。两组术后24 h 及术后1、3、6、 12 及24 个月视觉模拟评分（VAS）结果显示,PVP+ITR 组与PVP 组患者的VAS 评分变化趋势有差异,与PVP 组患者比较,PVP+ITR 组VAS 评分较低,相对镇痛效果较好（P <0.05）。两组患者的总体生存期、平均住院时 间比较差异无统计学意义（P >0.05）。PVP 联合ITR 组椎体骨水泥注射量高于PVP 组,而渗漏发生率低于PVP 组（P <0.05）。结论 PVP 联合ITR 具有镇痛性好、骨水泥渗漏率低、疗效确切的优点,是微创手术治疗脊柱转 移瘤所致压缩性骨折的有效方法。     

左半结肠癌致急性肠梗阻行Ⅰ期吻合98例疗效分析

目的探讨左半结肠癌致急性肠梗阻行Ⅰ期吻合的临床疗效。方法回顾性分析我院2000年—2010年98例左半结肠癌致急性肠梗阻行左半结肠Ⅰ期切除吻合患者的临床资料。结果本组98例患者行Ⅰ期吻合术均获治愈,其中出现吻合口瘘5例,切口液化感染8例,均经积极处理后痊愈,无术后腹腔脓肿、围术期死亡病例。术后并发症发生率为13.27%.结论治疗左半结肠癌致急性肠梗阻,只要选择合适病例,完善术中及围术期处理,行Ⅰ期吻合手术是安全、有效、可靠的。