自适应统计迭代重建技术算法在头颅CT扫描降低噪声中的对比分析

目的：分析不同的ASIR（自适应统计迭代重建技术）值在降低头部图像噪声中的价值。方法：采用型号为Discovery CT750 HD的宝石CT,对32例受检者进行头部扫描。扫描结束后在双侧侧脑室最大层面重建图像,FOV25cm、层厚5mm、间隔20mm,共5层,分别将ASIR值设定为0％、20％、40％、60％、80％、100％重建图像,窗宽为100HU、窗位为35HU。在一侧侧脑室内选取圆形感兴趣区,测量不同的ASIR值时侧脑室脑脊液的CT值与标准差,应用医学统计软件SPSS13对数据进行统计分析。结果：各组间侧脑室脑脊液的CT值标准差有明显的统计学差异,随ASIR百分比的增加,图像噪声水平明显降低。结论：提高ASIR值能够降低图像噪声。扫描时,采用较高ASIR值具有降低射线剂量的作用。     

橄榄桥脑小脑萎缩的临床表现及MR诊断价值

目的 探讨橄榄桥脑小脑萎缩（OPCA）的临床表现及其在MR影像表现上的特征性.方法 回顾性分析8例OPCA患者（OPCA组）的临床及MR表现.另选择75例健康体检者作为对照组,按年龄分为21 ～ 30岁组、31 ～ 40岁组,41～50岁组,51 ～ 60岁组,61 ～ 70岁组,每组15例,对所有研究对象均进行桥脑测量.结果 8例OPCA患者均为散发病例,临床以小脑症状、植物神经症状及锥体外系症状多见.头颅MR表现为小脑和脑干萎缩,特征性表现为“十字征”.OPCA组患者桥脑的上下径和前后径分别为（20.63±2.16）和（16.74±4.37） mm,与对照组[（27.14±1.73）和（22.28±1.49） mm]比较差异有统计学意义（P＜0.01）.对照组中在21 ～30岁组和31～ 40岁组桥脑上下径及前后径数值最大,随着年龄增大数值有所减小,但差异无统计学意义（P＞0.05）.结论 MR是诊断OPCA的首选检查方法,结合临床表现可以提高OPCA的诊断准确率.     

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??Efficacy of FOLFOX4 regimen systemic chemotherapy in treating advanced hepatocellular carcinoma: An analysis of 22 cases YIN Xiao-yu*??CHEN Jie??PENG Jian-xin??et al. *Department of Hepatobiliary Surgery??the First Affiliated Hospital of Sun Yat-sen University??Guangzhou 510080??China
Corresponding author??YIN Xiao-yu??E-mail??yinxy@21cn.com
Abstract Objective To evaluate the efficacy of FOLFOX4 regimen systemic chemotherapy in treating advanced hepatocellular carcinoma (HCC). Methods The clinical data of 22 cases of advanced HCC were treated by FOLFOX4 regimen systemic chemotherapy between July 2007 and July 2013 in the First Affiliated Hospital of Sun Yat-sen University were analyzed retrospectively. The chemotherapy was given each two weeks??with a maximum of 8 cycles. The therapeutic responses were evaluated each 3 cycles and end of treatment. Results A total of 85 cycles were administered in 22 cases??with a mean of ??3.7±2.0?? cycles /case. There were no complete response??5 partial responses??5 static diseases and 12 progressive diseases. The objective response rate was 22.7% (5/22)??and disease control rate was 45.4% (10/22)??with a one-year survival rate of 12.1% and median survival time of 5.8 months in the follow up of 2-34 ??8.5±1.9??months . In 10 cases of disease control after chemotherapy??the median survival time reached up to 9.5 months. Conclusion FOLFOX4 regimen systemic chemotherapy is effective in part of advanced HCC??and represented as an effective modality.     

急性呼吸道感染患儿鼻咽分泌物中呼吸道合胞病毒亚型的检出分析

目的探讨急性呼吸道感染患儿呼吸道合胞病毒(RSV)亚型的流行规律。方法应用直接免疫荧光法筛检2006年1月至2012年12月苏州地区42 208份来自急性呼吸道感染住院患儿的鼻咽分泌物标本的RSV病毒抗原;随机抽取不同年份RSV流行季节的RSV阳性标本,采用实时荧光PCR鉴定亚型。结果 RSV流行呈季节性,当年11月至次年3月为高峰期,而当年5至9月为RSV检出低谷期;从2006年至2012年,不同年份间高峰期的RSV阳性检出率差异有统计学意义(χ2=280.09,P0.01)。在398份不同年份高峰期的RSV抗原阳性标本中,检出A亚型319份(80.15%),B亚型63份(15.83%),未检出16份(4.02%),不同年份高峰期之间RSV亚型分布的差异有统计学意义(P0.01)。多数年份RSV流行以A亚型为主,在高峰期RSV检出率最低的2008—2009年A、B亚型同时流行,随后的2009—2010年以B亚型为主。结论苏州地区2006年至2012年,前四个流行季RSV检出率呈现周期性隔年增高趋势,之后两个流行季RSV感染呈持续高发趋势,急性呼吸道感染住院患儿RSV以A亚型为主。     

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??Abstract?? Objective To study balloon dilatation with cryotherapy under bronchoscope for subglottic stenosis in infants and young children??and to explore the efficacy of this new technology??the timing of treatment and safety. MethodFrom July 2009 to May 2014 in 28 SGS cases aged from 1 month to 3 years?? bronchoscopic balloon dilatation treatment with CO2 cryotherapy was performed?? and different types of SGS treated by minimal invasi were assessed regarding efficacy, complications and outcome. Results The infant SGS were divided into ??°~??° by severity?? and soft membrane SGS and scarring SGS by the causes of stenosis. ??° SGS included 16 cases, in which 8 cases soft membrane SGS were treated by balloon dilatation effectively?? 9 cases after combined treatment; in scarring SGS balloon dilatation was effective in 1 case?? 4 cases after combined therapy; ??° SGS included 8 cases?? soft membrane SGS were treated effectively in 2 cases?? 4 cases after combined treatment; in scarring SGS balloon dilatation was effective in 1 case?? 2 cases after combined therapy; ?? °SGS included 4 cases?? 1 case of soft membrane SGS and 1 case of scarring SGS responded well to integrated treatment .Conclusion MSCT and bronchoscopy assessment is used in grading the extent and causes of stratification in infants with subglottic stenosis?? and then we can select the appropriate treatment programs to improve the prognosis of the disease and improve life quality of SGS children.     

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??Abstract??The purpose of the present study was to show the different choices of periodontal surgeries in resolving various clinical problems. There were both demands of restoration in bilateral posterior areas of the patient??but their remaining of local dental tissue was different. In order to immediately restore the function and esthetic of the patient's dentition??the crown-lengthening surgery was applied on the side of more dental tissue available??the tooth was extracted on the other side of less dental tissue available and cureless apical lesion??also??implant surgery was applied electively. Soft and hard tissue augmentation was finished in implantation synchronously. The effect of final restorations was good and the patient was satisfied. The periodontal surgery played the key role in multidisciplinary treatment??therefore??its indications should be carefully and comprehensively chosen in overall treatment design.     

CXCL12/CXCR4信号通路与缺血性脑卒中新进展

缺血性脑卒中是一种严重威胁人类健康和生命的疾病,致残率和致死率较高。缺血性脑卒中会导致中枢神经系统损伤和功能障碍。缺血性脑卒中发生后,内皮祖细胞参与修复血管内皮和神经损伤,在这一过程中CXCL12/CXCR4 信号通路起着重要的作用。本文将对CXCL12/CXCR4 信号通路与缺血性脑卒中新进展进行综述。     

联合治疗法治疗食管静脉曲张破裂出血1168例

近年来国内开展了内镜下硬化和套扎术治疗肝硬化门静脉高压并食管胃底静脉曲张破裂出血,虽获得较好的疗效,但长期疗效仍不理想,尤其是血管闭塞消失率不高以及有曲张静脉闭塞后再通的可能性。笔者采用联合治疗法观察其对食管静脉曲张的长期疗效,现总结并分析如下。1　资料与方法1.1　临床资料:选择经胃镜检查证实的食管胃底静脉曲张伴有新鲜出血或非新鲜出血的患者1168例。其中男1098例,女70例;平均年龄52.8岁。肝炎后肝硬变1156例,酒精性肝硬化6例,胆汁性肝硬化3例,肝窦状核变性2例,Budd-Chiari综合征1例。肝功能Child分级为A级406例,B级5…