克拉霉素(利迈先)治疗小儿呼吸道感染104例临床分析

目的：探讨克拉霉素治疗小儿呼吸道感染的疗效。方法：克拉霉素治疗小儿呼吸道感染的疗效评价。结果：克拉霉素治疗小儿呼吸道感染,临床痊愈率为52．88％,临床有效率为98．08％。结论：克拉霉素治疗小儿呼吸道感染疗效确切,不良反应小。     

葡萄糖脱氢酶缓释系统PL-γ-PGA纳米颗粒的制备及研究

γ-聚谷氨酸(γ-PGA)是一种由枯草芽孢杆菌发酵生产的阴离子聚合物,具有良好的吸水性、生物相容性和生物降解性,无毒性且可由人体降解代谢,是一种很理想的药物载体。发酵得到的γ-PGA一般都具有很高的分子量,本文通过酸水解的方法,得到分子量符合药物载体要求的γ-PGA,并采用离子凝胶法,在水相反应体系中由低分子量γ-PGA与聚赖氨酸(PL)制备得到形态及表面特性良好的PL-γ-PGA纳米颗粒,粒径200～500 nm。在此基础上,制备了搭载葡萄糖脱氢酶(PQQ-GDHs)的PL-γ-PGA纳米缓释系统,载药效率达到61.2%,并且具有很好的稳定性,在体外模拟胃肠道和血液系统的缓释结果表明,分别有31.7%和40.2%的PQQ-GDHs在前48 h被释放。     

“二手男人”像木炭

现在的人对“二手”这两个宇很熟悉，什么二手车，二手房，二手电器等等多得很，但说到“二手男人”，许多人也许会很诧异。有人给“二手男人”下了定义，所谓二手男人，就是指曾经结过婚，”产权证”捏在某个女人手里的那种男人，因为种种或荒诞或堂皇的原因，原房东放弃了产权，他们又开始重新上市流通。     

氧化亚氮气腹的应用进展

腹腔镜手术发展至今，关于最佳充填气体的选择仍是一个反复讨论的话题。最初，用空气或氧气作为填充气体，然而氧气有腹腔内爆炸的危险，且空气或氧气在血液中溶解性差，容易引起静脉栓塞。1970～1980年，妇科手术首选氧化亚氮作为充填气体，它具备价格低廉，制备方便及病人疼痛轻等特点。     

你问我答

药师：正因为血脂异常具有早期无症状的特点,所以大多患者不够重视,等到高血脂加重、引起一系列并发症的时候,就会后悔没有及早治疗了,这也是高血脂的可怕之处。其实高血脂的危害性还是很严重的：高血脂是动脉粥样硬化最重要的原因,而动脉粥样硬化可进一步引起冠心病、心绞痛甚至心肌梗死,还可加重高血压;高血脂可以导致脂肪肝、肝硬化,还可以引发糖尿病。     

罗红霉素PK阿奇霉素

小王咳嗽多日,吃了家里常备的阿莫西林后,不见好转,无奈之下去了医院。在一系列问诊、检查、化验之后,医生告知是支原体感染,开的处方里除止咳药外,还有一盒罗红霉素胶囊。拿着处方,小王走进家门口的药店,营业员按方付药后,还说了一句“其实阿奇霉素比罗红霉素好得多”,于是,小王闲惑了……     

二氧化碳对小鼠神经母细胞瘤细胞跨间皮细胞迁移影响的实验研究

Objective This study was to assess the effect of CO2 pneumoperitoneum on transepithelial neuroblastoma cell migration. Methods Purification of primary murine peritoneal mesothelial cells was achieved by sequential, peritoneal lavage after 0. 125% trypsin pretreatment. Purity of the mesothelial cell culture was confirmed by cell morphology and immunohistochemical staining for specific cytokeratine (AE1/AE3). In all experiments vitality of the cells was confirmed by MTT assay. Monolayers of mesothelial cells were established on transwell systems. Following incubation with 100% CO2 or 5% CO2 for 2 h, fluorescent stained Neuro2a (neuroblastoma) cells were added to the upper chamber and their migration to the lower chamber was measured by multi - detection reader. Results The conversion of MTT was nearly same 4h, 6 h, 10 h and 24 h after 5% CO2 or 100% CO2 exposition,0. 82 ± 0. 28 VS 0. 62 ± 0. 22,0. 87 ± 0. 24 VS 0. 62 ± 0. 28, 0. 88 ± 0. 69 VS 0. 69 ± 0. 81 and 1. 05 ± 0. 86 VS 0. 97 ± 0. 25 respectively. Migration studies showed that the barrier function of the mesothelial monolayer decreased. A significantly increased migration of neuroblastoma cells was found after 100% CO2 exposure 258. 56 ± 71. 08 VS 77. 05 ± 27. 89 (P＜0. 05). Conclusions 100% CO2 facilitated transepithelial neuroblastoma cell migration. Thus, the increased neuroblastoma metastasis observed after CO2 pneumoperitoneum in mice might be related to an impaired mesothelial barrier function.