全文获取类型
收费全文 | 408篇 |
免费 | 12篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 8篇 |
妇产科学 | 4篇 |
基础医学 | 42篇 |
口腔科学 | 13篇 |
临床医学 | 30篇 |
内科学 | 74篇 |
皮肤病学 | 5篇 |
神经病学 | 23篇 |
特种医学 | 19篇 |
外科学 | 68篇 |
综合类 | 4篇 |
预防医学 | 63篇 |
眼科学 | 17篇 |
药学 | 31篇 |
中国医学 | 1篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 2篇 |
2022年 | 15篇 |
2021年 | 25篇 |
2020年 | 11篇 |
2019年 | 16篇 |
2018年 | 22篇 |
2017年 | 8篇 |
2016年 | 6篇 |
2015年 | 9篇 |
2014年 | 16篇 |
2013年 | 30篇 |
2012年 | 29篇 |
2011年 | 53篇 |
2010年 | 8篇 |
2009年 | 14篇 |
2008年 | 20篇 |
2007年 | 19篇 |
2006年 | 22篇 |
2005年 | 22篇 |
2004年 | 19篇 |
2003年 | 19篇 |
2002年 | 14篇 |
2001年 | 3篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1996年 | 1篇 |
1994年 | 3篇 |
1986年 | 1篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
排序方式: 共有420条查询结果,搜索用时 15 毫秒
1.
McGowan S Wynaden D Harding N Yassine A Parker J 《The Australian and New Zealand journal of mental health nursing》1999,8(3):104-108
Interacting with potentially aggressive patients is a common occurrence for nurses working in psychiatric intensive care units. Although the literature highlights the need to educate staff in the prevention and management of aggression, often little, or no, training is provided by employers. This article describes a benchmarking exercise conducted in psychiatric intensive care units at two Western Australian hospitals to assess staff confidence in coping with patient aggression. Results demonstrated that staff in the hospital where regular training was undertaken were significantly more confident in dealing with aggression. Following the completion of a safe physical restraint module at the other hospital staff reported a significant increase in their level of confidence that either matched or bettered the results of their benchmark colleagues. 相似文献
2.
Yassine Chtourou Maram Morjen Rahma Ammar Rania Mhiri Mohamed Jema Ines ELBini-Dhouib Hamadi Fetoui Najet Srairi-Abid Naziha Marrakchi Jed Jebali 《Nutrients》2022,14(14)
Natural polyphenols are widely reported to have a large range of pharmacological properties, especially antioxidant activities and free radical scavenging capacities. In this study, we investigate the effects of naringin, chlorogenic acid, and quercetin mixtures (NCQ) on renal fibrosis in streptozotocin (STZ)-induced diabetic aged rats and its underlying mechanisms for ten consecutive weeks. The oxidative defense system in the kidneys of treated rats was found to be improved. Several biomarkers were investigated including the blood urea nitrogen, creatinine, and uric acid. Moreover, antioxidant parameters were evaluated and we found that superoxide dismutase, catalase, glutathione peroxidase, Na+-K+-ATPase activities, the nitric oxide production, the protein carbonyl, the advanced oxidation protein products, lipid peroxidation, and reduced glutathione levels were all significantly balanced and close to control values. In addition, NCQ restored renal injuries and fibrosis as assessed by histological method and molecular biology investigation of the matrix metalloproteinase, the transforming growth factor-beta TGF-β, the tumor necrosis factor TNFα, and p53 expression. Our study proposes the NCQ combination as potential plant-derived bioactive compounds to prevent diabetic nephropathy. 相似文献
3.
Vaidehi Garg Jayabalan Nirmal Yassine Riadi Prashant Kesharwani Kanchan Kohli Gaurav Kumar Jain 《Journal of pharmaceutical sciences》2021,110(2):871-875
This work was aimed to improve the efficacy of tacrolimus in the treatment of endotoxin-induced uveitis (EIU) using propylene glycol modified lipid vesicles termed as proglycosome nano-vesicles (PNVs). PNVs were prepared by modified film hydration method. Experimental uveitis in rabbit eye was induced by an intravitreal injection of 20 μL of the endotoxin solution containing 100 ng of lipopolysaccharide endotoxin. In vivo efficacy of PNVs was determined by studying clinical symptoms of uveitis using slit lamp examination and by quantitatively measuring levels of tumor necrosis factor-alpha, interleukin-6, leukocytes and total proteins in aqueous humor, 24 h after intravitreal injection of endotoxin. Comparison was made with healthy, untreated and tacrolimus solution treated eyes. PNVs developed were nano-sized, deformable and showed sustained release of tacrolimus over period of 12 h. In vivo results indicated statistically significant difference between the effects of PNVs in the treatment of EIU compared to tacrolimus. PNV treatment not only subsides clinical symptoms of uveitis but also prevented breakdown of blood aqueous barrier. Tacrolimus loaded PNVs are potential new topical treatment for uveitis. 相似文献
4.
5.
6.
7.
8.
Symptom burden and information needs in prostate cancer survivors: a case for tailored long‐term survivorship care 下载免费PDF全文
9.
10.
Dynamic changes of the composition of plasma HDL particles in patients with cardiac disease: Spotlight on sphingosine‐1‐phosphate/serum amyloid A ratio 下载免费PDF全文
Emmanuel E Egom Haaris A Shiwani Rebabonye B Pharithi Rebecca Canning Barkat Khan Yassine El Hiani Vincent Maher 《Clinical and experimental pharmacology & physiology》2018,45(4):319-325
Several epidemiological studies reported an inverse relationship between plasma high‐density lipoprotein (HDL) cholesterol levels and atherosclerotic cardiovascular disease (ASCVD). However, therapeutic interventions targeted at raising HDL‐cholesterol failed to improve cardiovascular outcomes, suggesting that HDL components distinct from cholesterol may account for the anti‐atherothrombotic effects attributed to this lipoprotein. Sphingosine‐1‐phosphate (S1P) and the acute phase protein serum amyloid A (SAA) have been identified as integral constituents of HDL particles. Evidence suggests that S1P and SAA levels within HDL particles may be affected by inflammation and oxidative stress, which are coexisting processes underlying ASCVD. Because SAA, an inflammation‐related marker, and S1P, an anti‐atherothrombotic marker, have relatively clear opposite characteristics among the HDL‐associated proteins, the approach of assessing the two markers simultaneously may provide new insights in clinical practice (S1P/SAA Index). This review focuses on evidence in support of the concept that the S1P/SAA Index may affect the HDL atheroprotective properties and may, therefore represent a potential target for therapeutic interventions. 相似文献