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61.
我国较贫困地区农村学龄前儿童膳食状况 总被引:5,自引:0,他引:5
对1985~1989年7省较贫困的18个乡农村儿童膳食调查资料采用平均摄入量、临界值及概率法进行了总结分析。结果表明,6~24月龄母乳喂养儿的辅食品种单一,数量不足。断奶儿童各年龄组热能、蛋白质摄入量的平均值分别达RDA的92%~104%和76%~84%,但以RDA为界值,仍有53%~62%及74%~85%的儿童热能、蛋白质摄入量低,用概率法分析蛋白质、钙、维生素A、B2、C及铁摄入不足的人数比例分别是50%~60%、93%~97%、51%~87%、74%~86%、58%~66%和12%~47%。热能、蛋白质摄入量低于RDA值儿童的身高、体重明显低于摄入量高于RDA值的儿童。 相似文献
62.
生长激素在肝硬变门脉高压低蛋白血症手术前的应用研究 总被引:1,自引:1,他引:0
目的:研究生长激素(rhGH)对肝硬变门脉高压低蛋白血症患者手术前的治疗价值。方法:肝硬变门脉高压抑行脾切除、门奇静脉断流手术患者60例,Child分级B级,随机分为rhGH治疗组30例,对照组30例。rhGH组术前5d每天皮下注射rhGH 4IU,对照组给予安慰剂生理盐水。两组术前均行相同肠外营养支持。测定治疗前、治疗后3d、4d、5d血浆白蛋白、球蛋白、前白蛋白及空腹血糖。结果:rhGH组治疗后3d前白蛋白较治疗前及对照组明显升高(P<0.05),治疗后4d、5d仍维持较高水平;治疗后5d白蛋白较治疗前及对照组明显升高(P<0.05)。rhGH组患者一般情况改善,生活质量提高。对照组白蛋白、前白蛋白无明显变化。两组空腹血糖、球蛋白无明显改变。结论:rhGH联合肠外营养支持对纪正肝硬变门脉高压低蛋白血症患者术前低蛋白状态,改善生活质量有良好疗效,由于rhGH起效慢,应早期、足量、足疗程应用。 相似文献
63.
子宫内膜异位症是育龄妇女的常见疾病 ,近年来其发病率有上升趋势 ,研究认为EM发生发展与腹腔氧化作用有关。氧化作用是一种炎症反应 ,EM中巨噬细胞释放的氧化活性物 ,腹腔液中氧化低密度脂蛋白及其产物的增加 ,子宫内膜细胞氧化酶与抗氧化酶的异常表达 ,腹腔液中VitE的消耗 ,均说明EM与腹腔氧化作用有关。本文综述有关研究结果为用抗氧化剂和抗炎症制剂预防EM发生提供新的研究途径 相似文献
64.
脑脊液髓鞘碱性蛋白(MBP)自身抗体固相发光免疫分析法,是一项免疫检测新技术,目前国外尚未见到对脱髓病研究的报道。本文作者于1988.5~1989.3首先采用本法并证实其可靠性后,进入临床研究,对36例脱髓鞘病及20例其他CNS疾病者的对照组,用三项免疫指标行对比分析。CSFMBP自身抗体含量及其和同量IgG自身抗体的百分比值分别为69.23±11.95ng/ml及3.24±0.52ug/mg±gG和对照组相比,P值分别为<0.05及<0.001,有显著差异,对本病诊断有意义。 相似文献
65.
目的:评价传统的玻璃离子水门汀所产生的,特别是用于无创伤充填治疗技术时抑制体外釉质脱矿的能力.方法:二十四颗由于正畸治疗拔除的完整的恒前磨牙,在釉质颈部作洞型预备.这些牙齿分别用Fuji IX,Fuji IX GP,Ketac-Molar和复合玻璃充填材料充填,将它们放在5℃~55℃的温度下循环处理300次,后放在放在脱矿溶液(含有1g/l的溶解的羟磷灰石的0.1M的乳酸,pH为4.7)中四个星期.沿牙齿的长轴经充填体作平行于颊舌平面的切片,切片的厚度大约为100 μm.用偏振光显微镜检测这些切片,用图像分析软件分析病损大小,ANOVA和变异系数用于比较结果.结果:复合玻璃和Ketac-Molar比其它两种水门汀的表面腐蚀性小(P<0.01).用玻璃离子水门汀瞬间接触充填体边缘抑制釉质脱矿的能力(20.5%~25.0%)较复合玻璃材料强(13.0%).但是,抑制带的宽度因材料和位置的不同而有变异.结论:充填材料释放的氟离子在某种程度上为邻近釉质抵抗体外脱矿提供保护. 相似文献
66.
The purpose of the present study was to determine the reliability of several selected signs of trauma from occlusion and their relations with severity of periodontitis. 32 moderate to advanced chronic periodontitis patients participated in the study. All teeth present were evaluated for various abnormal occlusal contacts, signs of trauma from occlusion, and the severity of periodontitis. Standardized periapical radiographs were also taken for each tooth. The results demonstrated that: (1) no significant difference occurred in probing pocket depth (PD), clinical attachment loss (AL), or percentage of alveolar bone height (BH) between teeth with and without various abnormal occlusal contacts, i.e., premature contacts in centric relation occlusion, non-working contacts in lateral excursions, premature contacts of anterior teeth or posterior protrusive tooth contacts; (2) teeth with either significant mobility, functional mobility, or radiographically widened periodontal ligament space (PDLS) had deeper PD, more AL and lower BH than teeth without these signs, while teeth with pronounced wear or radiographically thickened lamina dura had less AL than teeth without these findings; (3) 2 combined indices, i.e., the trauma from occlusion index (TOI) and the adaptability index (AI), were proposed for the identification of occlusal trauma and the response of periodontium to excessive biting forces in heavy function, respectively; TOI-positive teeth exhibit deeper PD, more AL and less osseous support than TOI-negative teeth; however, AI-positive teeth had less AL and more osseous support than AI-negative teeth; (4) with identical attachment level, TOI-positive teeth had less osseous support than TOI-negative teeth while the magnitude of difference became greater with an increase of attachment loss. 相似文献
67.
急性脑梗死后血浆NO、NOS、ET含量的动态变化及尼莫地平对其影响 总被引:4,自引:0,他引:4
目的 观察急性脑梗死 (ACI)后血浆一氧化氮 (NO)、一氧化氮合成酶 (NOS)、内皮素 (ET)含量的动态变化 ,以及尼莫地平治疗后对其影响。方法 ACI患者 110例 ,随机分成尼莫地平组 (5 0例 ) (在常规治疗基础上用尼莫地平 )和常规治疗组 (6 0例 )。在发病后不同时点动态观察血浆NO、NOS、ET含量 ,并设 5 0例脑动脉硬化患者为对照组。结果 脑梗死后血浆ET含量显著升高 ,直至恢复期 ;NO、NOS先增高后下降 ;尼莫地平组和常规组比较ET有显著差异 (P <0 .0 1) ,NO、NOS差别不显著 (P >0 .0 5 )。结论 NO、NOS、ET参与并影响了ACI后复杂的病理生理过程 ;尼莫地平部分通过对ET含量的影响发挥其对脑梗死的治疗作用 相似文献
68.
With the development of interventional therapy, it is necessary for evaluating cerebral vessels to instruct treatment and determine prognosis of patients with ischemic stroke; however, correlation of distribution of infarction focus and clinical symptoms with degrees of cerebrovasoular stricture is still unclear.OBJECTIVE: To evaluate the characteristics of cerebral arterial stricture of patients with ischemic stroke with transcranial Doppler (TCD) and color duplex flow imaging (CDFI) and compare the correlation between distribution of cerebral infarction focus and clinical types with magnetic resonance imaging (MRI).DESIGN: Contrast observation.SETTING: Department of Neurology, the First Hospital of Jilin University.PARTICIPANTS: A total of 159 patients with ischemic stroke were selected from the Department of Neurology, the First Hospital of Jilin University from January to December 2005, including 106 males and 53 females aged from 27 to 88 years. Bases on diagnostic criteria of cerebrovascular disease established by Rao et al, clinical manifestations of all patients were evaluated with CT or nuclear magnetic resonance. All patients provided the confirmed consent.METHODS: The accepted patients received TCD and CDFI examination at 1 week after onset of ischemic stroke. Among them, 112 patients received cerebrovascular imaging examination simultaneously. MRI was used to check cerebral infarction focus and cerebrovascular stricture > 50% was regarded as the accepted vessels. In addition, DWI-T2 TCD (Germany) was used to check middle cerebral artery, and degrees of middle cerebral artery were classified into mild, moderate and severe stricture based on blood velocity (140 cm/s,180 cm/s). Stroke was classified based on characteristics of infarction focus and clinical symptoms showed with MRI and correlation with degrees of cerebrovascular stricture was analyzed simultaneously.MAIN OUTCOME MEASURES: Correlation between the characteristics of ischemic stroke and clinical symptoms checked with TCD and CDFI.RESULTS: A total of 159 patients with ischemic stroke were involved in the final analysis; in addition, 112 oases received cerebrovascular imaging examination simultaneously. ① MRI results of 159 patients with cerebral artery occlusive disease (CAOD): There were 131 patients (82.3%) with cerebral infarction, 40 (25.2%)with transient ischemic attack and 4 (2.5%) with subclavian steal syndrome (SSS). ② Infarction types with MRI examination: There were 33 patients (20.8%) with solitary cerebral infarction and 98 (61.6%) with multiple-cerebral infarction. ③ Results of TCD, CDFI, MRI angiography, CT angiography and digital subtraction angiography (DSA): Among 112 patients, 181 lesion sites (61 .8%) were located in cranium and 112 lesion sites were located out of cranium; especially, lesion site was mostly observed in stem of middle cerebral artery (31.2%) and watershed of basilar artery (7.2%) in cranium and the beginning site of internal carotid artery (21 .4%) out of cranium. ④ Correlation of vascular stricture checking with TCD, MRI and clinical diagnosis: On one hand, MRI and clinical diagnosis demonstrated that 68 patients had a watershed infarction; meanwhile,TCD examination indicated that there were 3 patients with mild vascular stricture, 24 with moderate vascular stricture and 36 with severe vascular stricture. On the other hand, among 68 patients with non-watershed infarction, there were 27 patient with mild vascular stricture, 26 with moderate vascular stricture and 15 with severe vascular stricture. There were significant differences (x2 =26.854, P =0.001 ). Clinical diagnosis indicated that 40 patients had transient ischemic attack and TCD examination demonstrated that there were 8 patient with mild vascular stricture, 12 with moderate vascular stricture and 20 with severe vascular stricture. There were significant differences as compared with 68 patients with watershed infarction (x2 =21.258, P =0.001). ⑤Correlation of vascular stricture checking with CDFI, MRI and clinical diagnosis: On one hand, among patients who were determined as watershed infarction with MRI and clinical diagnosis, CDFI examination indicated that there were 32 patients with mild vascular stricture at neck, 25 with moderate vascular stricture and 6 with severe vascular stricture. On the other hand, among patients with non-watershed infarction, there were 48 patient with mild vascular stricture, 18 with moderate vascular stricture and 2 with severe vascular stricture.There were significant differences (x2 =6.018, P =0.019). Among patients with transient ischemic attack checking with clinical diagnosis, there were 23 patient with mild vascular stricture, 9 with moderate vascular stricture and 8 with severe vascular stricture. There were no significant differences as compared with patients with non-watershed infarction (x2 =0.597, P=0.440).CONCLUSION: ① TCD and CDFI are effective marks to determine cerebral arterial stricture and hemodynamical changes. ② Infarction and transient ischemic attack at watershed are generally clinical phenotypes of CAOD patients and infarction at watershed is correlated with degrees of cerebrovascular stricture.③ TCD, MRI and clinical analysis of stroke types are significant for instructing treatment and evaluate prognosis. 相似文献
69.
法莫替丁冲剂在健康人中的生物利用度及药动学研究 总被引:1,自引:0,他引:1
本实验采用反相高效液相色谱法,比较了10名健康志愿者单剂量口服法莫替丁冲剂及等剂量片剂的生物利用度。结果表明:二种剂型的Tmax,Cmax,AUC均无显著性差异(P〉0.05)。冲剂相对于与片剂的相对生物利用度F=101.90。 相似文献
70.
Wang Tao Liang Zhihou Sun Shenggang Cao Xuebing Peng Hai Cao Fei Liu Hongjin Tong E-tang 《华中科技大学学报(医学英德文版)》2003,23(2):145-147
Summary To investigate the distribution of possible novel mutations from parkin gene in variant subset of patients with Parkinson’s
disease (PD) in China and explore whether parkin gene plays an important role in the pathogenesis of PD, 70 patients were
divided into early-onset group and late-onset group; 70 healthy subjects were included as controls. Genomic DNA from 70 normal
controls and from those of PD patients were extracted from peripheral blood leukocytes by using standard procedures. Mutations
of parkin gene (exon 1–12) in all the subjects were screened by PCR-single strand conformation polymorphism (SSCP), and further
sequencing was performed in the samples with abnormal SSCP results, in order to confirm the mutation and its location. A new
missense mutation Gly284Arg in a patient and 3 abnormal bands in SSCP electrophoresis from samples of another 3 patients were
found. All the DNA variants were sourced from the samples of the patients with early-onset PD. It was concluded that Parkin
point mutation also partially contributes to the development of early-onset Parkinson’s disease in Chinese.
WANG Tao, male, born in 1961, Associate Professor
This work was supported by grants from the key program of the special scientific project of Scientific & Technologic Agency
of Hubei Province (Serial No. 2001AA308B01) and the Hygienic Research Project of Hygienic Agency of Hubei province (Serial
No. WJ 01529). 相似文献