柔红霉素长春新碱体外对人急性髓系白血病细胞株的相互作用

目的：观察柔红霉素、长春新碱联合应用在体外对人急性髓系白血病细胞株（HL－60）的相互作用。方法：采用MTT法，利用中效原理判断联合用药的效果。结果；两种药物单用及联合应用时随着药物剂量增加，其效应也增加。两药大剂量合用时为拮抗效应，较小剂量合用时为协同效应。两药合用时（除最小剂量外）与先用柔红霉素24小时或先用长春新碱24小时比较P＜0．01；小剂量合用时先用柔红霉素24小时与先用长春新碱24小时比较P＞0．05。两药合用时浓度变化会影响合用效应。结论：柔红霉素与长春新碱合用时大剂量为拮抗，较小剂量为协同；合用效应大小与两种药物浓度比例有关；与给药先后次序无关，同时给药效果好。     

凝胶法鲎试验检测金纳多注射液中的细菌内毒素

目的　应用凝胶法鲎试验检测金纳多注射液中的细菌内毒素含量。方法　经干扰试验验证样品在若干稀释倍数下 ,对鲎试验无干扰作用。结果　将样品进行 1 6稀释可以有效地消除其对鲎试验的干扰。结论　凝胶法鲎试验可以检测金纳多注射液中的细菌内毒素含量     

易善复治疗重型肝炎22例疗效观察

目的:探讨易善复对重型肝炎的治疗作用。方法:选择43例重型肝炎患者,分治疗组22例,对照组21例。分别于治疗前后检测肝功能及凝血酶原时间,并进行疗效判断。结果:治疗组治疗后肝功能好转明显优于对照组,总有效率治疗组为59.1％,对照组28.6％,差异显著。结论:易善复可提高重型肝炎的疗效。     

颈动脉粥样硬化斑块高分辨磁共振成像扫描方法

目的:规范颈动脉粥样硬化斑块高分辨磁共振成像方法,优化扫描序列及参数.材料和方法:采用颈动脉专用线圈,选用2D-TOF、3D-TOF、T1WI、T2WI、PDWI等脉冲序列,对156例不同程度脑缺血症状患者行颈动脉斑块多序列多方位扫描.结果:156例受检者除2名不能配合未完成扫描外,其余均顺利完成.T1WI、T2WI、PDWI和3D-TOF的序列组合能准确显示血管壁、血流、斑块大小、形态及斑块内成分.其中62例显示明确斑块形成(最大狭窄＞50%),34例判定为稳定斑块;28例判定为不稳定斑块,其中手术病理证实22例,病理提示斑块纤维帽不完整、部分合并出血钙化及巨大脂质池.结论:采用颈动脉专用表面线圈,选用合适的扫描序列及参数所得到的图像能有效显示斑块,为临床治疗方案的选择及术后随访提供依据.     

中药漏芦的本草考证

通过考证,作者认为中药漏芦的正品应该是菊科植物祁州漏芦Rhaponticum uniflorum的干燥根。而中国药典1990年版收载的漏芦正品之一禹州漏芦Echinops latifolius缺乏本草依据,化学成分亦与祁州漏芦完全不同,因此建议不宜作为正品漏芦使用。     

A phase II Southwest Oncology Group study of cisplatin and continuous infusion vinblastine in the treatment of advanced soft tissue sarcoma

Purpose and Methods: Bone and soft tissue sarcomas currently comprise 1% of adult malignancies and 15% of pediatric malignancies [1]. While doxorubicin and ifosfamide are active agents, no significant impact on survival has been observed. More active regimes are required in sarcoma. This trial studied cisplatin and a 5 day continuous infusion of vinblastine for patients who had had disease progression of advanced soft tissue sarcoma after a doxorubicin based regimen.Results: Between July 1983 and October 1986, 20 patients entered the study. There were no treatment related deaths. Seven patients required dose adjustment for neutropenia. No responses were observed.     

The reproductive toxicity of cadmium chloride in male mice

Objective: To study the reproductive toxicity of cadmium chloride in male mice. Methods: Male mice of 4 weeks old were administered cadium chloride at doses of 0.5, 2 or 8 mg·kg-1·day-1 i.p. for 10 days. At day 50, the males were mated with virgin females at 1: 2. The pregnancy rate, the litter size and the body weight of the offspring were recorded; at the same time the development of the testis, the testicular index, the germ cell miosis and the epididymal sperm count, motility and malformed sperm were observed in the intoxicated males. Results: The testicular index was lower in the 2 and 8 mg/kg groups than in the controls and 0.5 mg/kg groups (P< 0.05). In the 2 and 8 mg/kg groups, there were testicular maldeve-lopment, epididymal azoospermia and infertility. The pregnancy rate was lower in the 2 mg/kg group than in the control and 0.5 mg/ kg group (P<0.05). The ectopic pregnancy rate of the cadmium chloride group was not significantly different from that of the controls. The sperm count, motility     

保肺定喘汤对肺气肿大鼠病理的影响

目的：观察保肺定喘汤对肺气肿大鼠病理形态的影响及与血浆内皮素(ET-1)的关系。方法：采用SO2、木瓜蛋白酶定量刺激造模。分三个剂量组予保肺定喘汤治疗。结果：保肺定喘汤各剂量组大鼠TVL／体重下降，排除／灌注体积比增大，单位面积肺泡数增加，平均肺泡面积减小，ET-1升高不明显，与模型组比较差异显著，又各剂量组间呈量-效依赖关系。镜下见保肺定喘汤各组大鼠肺脏病损明显减轻。结论：保肺定喘汤能明显改善致模因素对大鼠肺脏造成的病理损害，对实验性肺气肿大鼠有较好的防治作用。其作用机制可能与ET-1的拮抗作用相关。     

创伤大鼠痛阈变化规律及电针效应

<正> 疼痛是生理学和临床上迫切需要解决的难题,创伤又是临床上致病的主要因素之一。本文以截肢造成创伤痛,利用它具有一个发生、发展及转归的自然变化过程,动态观察了创伤引起大鼠尾及伤肢痛阈变化的规