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571.
C. Nishio R. Wazen S. Kuroda P. Moffatt A. Nanci 《Journal of periodontal research》2010,45(6):709-713
Nishio C, Wazen R, Kuroda S, Moffatt P, Nanci A. Disruption of periodontal integrity induces expression of apin by epithelial cell rests of Malassez. J Periodont Res 2010; 45: 709–713. © 2010 John Wiley & Sons A/S Background and Objective: It has been suggested that epithelial cell rests of Malassez (ERM) may express enamel matrix proteins and play an important role in periodontal regeneration. Two novel proteins, apin (APIN) and amelotin (AMTN), produced by maturation‐stage ameloblasts and junctional epithelium, have recently been identified. The objective of this study was to evaluate whether the ERM express APIN and AMTN under normal conditions and after periodontal challenge. Material and Methods: Gingivectomy and orthodontic tooth movement were carried out on the left side of the maxillae of rats. The control group included the untreated contralateral side of these animals and the maxillae of normal, untreated rats. Animals were sacrificed by intracardiac perfusion on days 3 and 5 after the experimental procedures and maxillary molars were decalcified and processed for paraffin embedding. Immunohistochemistry was used to evaluate the expression of various ameloblast products, including APIN, AMTN, ameloblastin (AMBN) and amelogenin (AMEL). Results: At 3 and 5 days after periodontal challenge, ERM were more evident in the periodontal ligament along the root surface and in the root furcations. Immunodetection of APIN, but not of the other three proteins, was observed in the ERM following the disruption of periodontal integrity. No immunolabeling for APIN, AMTN, AMBN and AMEL was detected in the ERM under normal conditions. Conclusion: The expression of APIN at an early time‐point following disruption of periodontal integrity suggests that this protein may be part of the cascade of events leading to the activation of ERM during periodontal healing and regeneration. 相似文献
572.
Shantini Paranjothy John Gallacher Richard Aml?t G James Rubin Lisa Page Tony Baxter Jeremy Wight David Kirrage Rosemary McNaught SR Palmer 《BMC public health》2011,11(1):145
Background
The summer of 2007 was the wettest in the UK since records began in 1914 and resulted in severe flooding in several regions. We carried out a health impact assessment using population-based surveys to assess the prevalence of and risk factors for the psychosocial consequences of this flooding in the United Kingdom. 相似文献573.
Faizal Rayan Vittal SR Rao Sanjay Purushothamdas Cibu Mukundan Syed O Shafqat 《Journal of orthopaedic surgery and research》2010,5(1):31
The aim of our study was to analyse the efficacy of operative management in recalcitrant lateral epicondylitis of elbow. Forty
patients included in this study were referred by general practitioners with a diagnosis of tennis elbow to the orthopaedic
department at a district general hospital over a five year period. All had two or more steroid injections at the tender spot,
without permanent relief of pain. All subsequently underwent simple fasciotomy of the extensor origin. Of forty patients thirty
five had improvement in pain and function, two had persistent symptoms and three did not perceive any improvement. Twenty
five had excellent, ten had well, two had fair and three had poor outcomes (recurrent problem; pain at rest and night). Two
patients underwent revision surgery. Majority of the patients had improvement in pain and function following operative treatment.
In this study, an extensor fasciotomy was demonstrated to be an effective treatment for refractory chronic lateral epicondylitis;
however, further studies are warranted. 相似文献
574.
SR Mehta AVSM VSM PHS & Col Comdt) Maj V Suhag M Semwal N Sharma 《Medical Journal Armed Forces India》2010
Radiation therapy (RT) is a clinical modality dealing with the use of ionizing radiations to treat malignant neoplasias (and occasionally benign diseases). Since its inception, the goal of RT has been to cure cancer locally without excessive side effects. The most important factors affecting the results of RT are the tumor type, its location and regional extent, the anatomic area of involvement and the geometric accuracy with which a calculated radiation dose is delivered. Although higher doses of radiation can produce better tumor control, the dosage which can be given is limited by the possibility of normal tissue damage. Approximately 60-65% of all cancer patients require RT as the sole treatment modality and / or in combination with surgery or chemotherapeutic drugs. There is a huge gap between demand and supply of radiotherapy facilities and infrastructure. Most of the oncocentres are located in urban areas in private sector and are beyond the reach of the common man. 相似文献
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