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Baş VN Ozkan M Zenciroğlu A Cavuşoğlu YH Cetinkaya S Aycan Z 《Journal of pediatric endocrinology & metabolism : JPEM》2012,25(5-6):553-555
The most common reason for refractory hypoglycemia in newborns is congenital hyperinsulinism. We report a girl with congenital hyperinsulinism due to novel homozygous mutation (c.2041-25 G>A; aberrant splicing mutation) in the ABCC8 gene encoding SUR1 and during somatostatin analog (octreotide) discontinuation developed by nonhypoglycemic seizures. The newborn (birth weight of 3,750 g) was referred to our clinic because of hypoglycemic seizures at 4 h postnatal. On admission, blood glucose was 24 mg/dL and intravenous glucose infusion was started. The patient's insulin level was 27 mIU/mL during the hypoglycemic period. Phenobarbital (5 mg/ kg/day) was added because of short-acting generalized clonic seizures. Although the patient received high doses of diazoxide, esidrex, and octreotide approximately for 2 months, hypoglycemic episodes continued. Then the patient had near-total pancreatectomy, and pathology confirmed a diffuse form of congenital hyperinsulinism. There was homozygous mutation in the ABCC8 gene encoding SUR1, which confirmed the diagnosis of autosomal recessive congenital hyperinsulinism. During octreotide discontinuation, the patient developed non-hypoglycemic seizures, which were controlled by restarting the previous doses. In the light of in vitro and in vivo studies on antiepileptic effects of somatostatin, we believe that seizures in our case have developed secondary octreotide discontinuity. 相似文献
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Riza Madazli Veysel Şal Tayfur Çift Onur Guralp Abdullah Goymen 《Archives of gynecology and obstetrics》2010,281(1):29-34
Aim
To evaluate the maternal and fetal outcome of pregnancies complicated by cardiac disease in a developing country.Methods
A retrospective analysis was carried out of 144 pregnancies in women with cardiac disease who delivered in our unit between 1997 and 2006. Perinatal and maternal outcomes were interpreted according to the type of the heart disease and status of the patient according to the New York Heart Association (NYHA) classification.Results
The rates of rheumatic and congenital heart disease were 87.5 and 12.5%, respectively. The distribution of the patients according to the NYHA functional classification were 55.6, 36.1 and 8.3% for NYHA classes I, II and III–IV, respectively. There was no maternal mortality. Maternal morbidity was observed in 16 (11.1%) cases. Six perinatal mortalities (4.2%) occurred in this series. There were no significant difference in birth weight, gestational age at delivery and perinatal morbidity between the NYHA stage I–II and stage III–IV groups (P > 0.05), whereas maternal morbidity and cesarean delivery rates were significantly higher in the NYHA stage III–IV group (P < 0.001).Conclusion
Rheumatic heart disease with pregnancy is still predominant in Turkey. Most of the patients were in a good functional group. Maternal morbidity strongly correlates with maternal cardiac classification. 相似文献65.
Burulday Veysel Bayar Muluk Nuray Kmrc Erkmen Selmin Perihan Akgl Mehmet Hseyin zdemir Adnan 《Neurosurgical review》2021,44(3):1533-1541
Neurosurgical Review - In this retrospective study, we aimed to present important anatomical structures and distances for posterior fossa surgery by temporal multidetector computed tomography... 相似文献
66.
Evaluation of alpha and gamma aluminum oxide nanoparticle accumulation,toxicity, and depuration in Artemia salina larvae 下载免费PDF全文
Mehmet Ates Veysel Demir Zikri Arslan James Daniels Ibrahim O. Farah Corneliu Bogatu 《Environmental toxicology》2015,30(1):109-118
In this study, Artemia salina (crustacean filter feeders) larvae were used as a test model to investigate the toxicity of aluminum oxide nanoparticles (Al2O3 NPs) on marine microorganisms. The uptake, toxicity, and elimination of α‐Al2O3 (50 nm and 3.5 μm) and γ‐Al2O3 (5 nm and 0.4 μm) NPs were studied. Twenty‐four and ninety‐six hour exposures of different concentrations of Al2O3 NPs to Artemia larvae were conducted in a seawater medium. When suspended in water, Al2O3 NPs aggregated substantially with the sizes ranging from 6.3 nm to >0.3 µm for spherical NPs and from 250 to 756 nm for rod‐shaped NPs. The phase contrast microscope images showed that NPs deposited inside the guts as aggregates. Inductively coupled plasma mass spectrometry analysis showed that large particles (3.5 μm α‐Al2O3) were not taken up by Artemia, whereas fine NPs (0.4 μm γ‐Al2O3) and ultra‐fine NPs (5 nm γ‐Al2O3 and 50 nm α‐Al2O3) accumulated substantially. Differences in toxicity were detected as changing with NP size and morphology. The malondialdehyde levels indicated that smaller γ‐Al2O3 (5 nm) NPs were more toxic than larger γ‐Al2O3 (0.4 µm) particulates in 96 h. The highest mortality was measured as 34% in 96 h for γ‐Al2O3 NPs (5 nm) at 100 mg/L (LC50 > 100 mg/L). γ‐Al2O3 NPs were more toxic than α‐Al2O3 NPs at all conditions. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 109–118, 2015. 相似文献
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The clinical application of detecting COVID-19 factors is a challenging task. The existing named entity recognition models are usually trained on a limited set of named entities. Besides clinical, the non-clinical factors, such as social determinant of health (SDoH), are also important to study the infectious disease. In this paper, we propose a generalizable machine learning approach that improves on previous efforts by recognizing a large number of clinical risk factors and SDoH. The novelty of the proposed method lies in the subtle combination of a number of deep neural networks, including the BiLSTM-CNN-CRF method and a transformer-based embedding layer. Experimental results on a cohort of COVID-19 data prepared from PubMed articles show the superiority of the proposed approach. When compared to other methods, the proposed approach achieves a performance gain of about 1–5% in terms of macro- and micro-average F1 scores. Clinical practitioners and researchers can use this approach to obtain accurate information regarding clinical risks and SDoH factors, and use this pipeline as a tool to end the pandemic or to prepare for future pandemics. 相似文献
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Tufan Tükek Pinar Yildiz Vakur Akkaya Mehmet Akif Karan Dursun Atilgan Veysel Yilmaz Ferruh Korkut 《Annals of noninvasive electrocardiology》2002,7(3):222-227
Background: Supraventricular tachyarrhythmia is a common problem in chronic obstructive pulmonary disease (COPD) patients. The purpose of this study is to analyze the factors associated with paroxysmal atrial fibrillation (AF) in COPD patients. Methods: Forty COPD patients (38 male, 2 female, mean age 60 ± 9 years) and 33 healthy controls (29 male, 4 female, mean age: 58 ± 10 years) were included in this study. Echocardiography, 24‐hour ambulatory and 12‐lead ECG, pulmonary function tests, arterial blood gases, and serum electrolytes were measured. On ECG, maximum (Pmax) and minimum (Pmin) duration of P wave and its difference, P‐wave dispersion (PWd), were measured. Results: On echocardiography, diastolic dysfunction was found in 14 of the 40 (35%) COPD patients. Heart rate variability analysis revealed that COPD patients had decreased SDANN, SDNN, SDNNIDX in time‐domain, and decreased LF in frequency domain parameters. Fourteen of the 40 COPD patients (35%) had AF. Patients with AF were older (57 ± 10 vs 64 ± 5 years, P = 0.03) and had lower SDANN, SDNN, and LF/HF ratio as compared to patients without AF in univariate analysis. All P‐wave intervals (Pmax Pmin and PWd) were increased in COPD patients compared to controls. P‐wave dispersion was significantly increased in COPD patients with AF, as compared to patients without AF (57 ± 11 vs 44 ± 7 ms, P = 0.001). In logistic regression analysis PWd was found to be the only factor associated with the development of AF (P = 0.04). Conclusions: The presence of AF was significantly related to the prolongation of PWd, but not with pulmonary function, arterial blood gasses, and left and right atrial function. A.N.E. 2002;7(3):222–227 相似文献
70.
Tarçin O Gedik N Karakoyun B Tahan V Sood G Celikel C Tözün N 《Digestive diseases and sciences》2008,53(7):1938-1945
AIM: Our aim was to study the correlation of serum prolidase and insulin like growth factor-1 to liver collagen and assess their utility as markers of fibrosis during four different periods of hepatic injury and fibrosis after bile-duct ligation in rats. METHODS: Forty-eight Wistar albino rats were included in the study and divided into six groups. Seven rats served as the control group (Control), while seven rats had a sham operation (Sham group). Thirty-four rats underwent bile-duct ligation. Bile-duct ligated (BDL) animals were sacrificed at the end of the first week (Group 1; n = 8), second week (Group 2; n = 8), third week (Group 3; n = 9), or fourth week (Group 4; n = 9) after BDL. Liver collagen, liver prolidase, and serum prolidase and IGF-I, were determined. RESULTS: There was a positive correlation between liver collagen and serum prolidase (r(s): 0.843, P < 0.001) levels and a negative correlation among liver collagen and serum IGF-1 levels (r(s): -0.667, P < 0.001). The peak levels of liver collagen and serum prolidase were reached in the third week while the lowest levels of IGF-1 were found at the end of the third week. CONCLUSION: Serum prolidase and IGF-1 either independently or in combination correlate with liver collagen content in hepatic fibrosis. 相似文献