全文获取类型
收费全文 | 132篇 |
免费 | 4篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 1篇 |
妇产科学 | 1篇 |
基础医学 | 16篇 |
口腔科学 | 9篇 |
临床医学 | 15篇 |
内科学 | 23篇 |
神经病学 | 7篇 |
特种医学 | 7篇 |
外科学 | 19篇 |
预防医学 | 2篇 |
眼科学 | 12篇 |
药学 | 9篇 |
中国医学 | 5篇 |
肿瘤学 | 7篇 |
出版年
2023年 | 1篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 3篇 |
2012年 | 5篇 |
2011年 | 6篇 |
2010年 | 4篇 |
2009年 | 3篇 |
2008年 | 3篇 |
2007年 | 7篇 |
2006年 | 6篇 |
2005年 | 5篇 |
2004年 | 14篇 |
2003年 | 12篇 |
2002年 | 9篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 8篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1992年 | 4篇 |
1991年 | 3篇 |
1989年 | 4篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1983年 | 2篇 |
1980年 | 2篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1966年 | 1篇 |
排序方式: 共有137条查询结果,搜索用时 15 毫秒
41.
Shigemura K Yasufuku T Yamanaka K Yamahsita M Arakawa S Fujisawa M 《Urological research》2012,40(4):373-376
Ureteroscopic lithotripsy (UL), for renal or ureteral stones, is a standard technique for every urologist. However, the length of time the double J (DJ) stent needs to be kept in postoperatively is still controversial. This study investigated how the duration of DJ stenting after UL affects postoperative adverse events, especially infection and pain. One hundred and twenty-five patients were enrolled in this study and data were analyzed retrospectively. We set the median duration for keeping the DJ stent postoperatively as 14 days from median value in all cases and compared it to a longer duration group (>15 days) and a shorter duration group (<14 days) in terms of febrile complications, urinalysis, and the need to give antibiotics at the time of DJ stent removal. The duration of DJ stenting was from 3 to 61 (median 14) days. Thirteen patients had adverse events related to DJ stent removal (febrile complications, 11 patients; lumbago, 2 patients). Thirty-one patients were given antibiotics at the time of DJ stent removal. Patients with longer durations (>15 days) of DJ stenting had a significantly higher ratio of adverse events such as fever or lumbago (p = 0.041). In conclusion, this study demonstrated that shorter duration (<14 days) DJ stent use after UL may decrease adverse events and require less antibiotic use. Further prospective studies are needed to determine the optimal duration of DJ stent use after UL. 相似文献
42.
Tacharoenmuang Ratana Guntapong Ratigorn Upachai Sompong Singchai Phakapun Fukuda Saori Ide Tomihiko Hatazawa Riona Sutthiwarakom Karun Kongjorn Santip Onvimala Napa Luechakham Tipsuda Ruchusatsawast Kriangsak Kawamura Yoshiki Sriwanthana Busarawan Motomura Kazushi Tatsumi Masashi Takeda Naokazu Yoshikawa Tetsushi Murata Takayuki Uppapong Ballang Taniguchi Koki Komoto Satoshi 《Virus genes》2021,57(4):338-357
Virus Genes - The exact evolutionary patterns of human G4P[6] rotavirus strains remain to be elucidated. Such strains possess unique and strain-specific genotype constellations, raising the... 相似文献
43.
E Ashihara N Oku A Nishio K Tuji M Nakamura 《[Rinshō ketsueki] The Japanese journal of clinical hematology》1992,33(12):1818-1823
A 64-year-old female was admitted for treatment of refractory myeloma (IgG-lambda). Because of severe liver cirrhosis, the patient was treated with interferon (IFN) alone (natural IFN 6 x 10(6) IR/day i.m. for 28 days). Pneumonia developed during IFN therapy. The IFN therapy was completed, restoring suppressed IgM and IgA to their normal ranges, while pneumonia was cured by antibiotics. Because the M-component remained, an additional IFN therapy was resumed and M-protein disappeared. As the period within which the M-component disappeared in this case was shorter than that reported previously, we supposed that the pneumonia might have enhance the effects of IFN. To verify this, we administered OK-432 for 4 weeks as a model of immunoactivation by pneumonia between two successive courses of IFN therapy when M-protein reappeared. To monitor the immune state, natural killer (NK) and lymphokine activated killer (LAK) activities were measured: NK activity suppressed by IFN was restored by OK-432 and was suppressed less by subsequent IFN administration. LAK activity was increased by IFN and OK-432. These observations suggested synergic effects of OK-432 on IFN-activated immunity. This case suggests that IFN combined with immunotherapy may be effective in some cases of myeloma. 相似文献
44.
45.
Akiko Imamura Tomohiko Kusuhara Masasi Nakajima Masayuki Tuji Tatsuo Yamada 《Clinical neurology》2002,42(8):750-753
48-year-old left-handed man experienced a sudden loss of taste, followed by dysarthria and dysphagia. Taste threshold examined by a small filter-paper disc method was severely elevated on both sides of the tongue. Brain CT revealed right putaminal hemorrhage that measured 9.3 ml in volume. In addition, brain MRI showed multiple cerebral infarcts bilaterally in the basal ganglia, and the corona radiata, and on the right side of the middle pontine tegmentum. His dysarthria and dysphagia seemed to be caused by interruption of bilateral cortico-bulbar tracts, and resolved within two weeks when edema around the hemorrhage regressed. The gustatory disturbance that persisted may be caused by the interruption of central gustatory pathways at the pons on one side, and subcortically close to the insular cortex on the other side. 相似文献
46.
Midori Misumi Haruko Ideguchi Takashi Tuji Atuhisa Ueda Shigeru Ohno Eri Hagiwara Akiko Aoki Yoshiaki Ishigatsubo 《Nihon Rinshō Men'eki Gakkai kaishi》2002,25(3):263-269
A 25-year-old female who had right knee and ankle joint swelling with arthralgia in July 1999, was diagnosed as having eosinophilic fasciitis (EF) based on typical skin sign and the result of muscle biopsy. Treatment was started with 20 mg of oral prednisolone per day. Her symptoms had subsided but they later recurred as the prednisolone dose was gradually tapered. We measured her serum cytokine levels during the course. Her serum IFN-gamma increased and IL-4 decreased after the treatment compared with those levels prior to treatment. And the cytokine levels reverted to pre-treatment status when she had a relapse. The cytokine balance seems to play some role in the etiology of EF. 相似文献
47.
Tomihiko Yasufuku Katsumi Shigemura Kazushi Tanaka Soichi Arakawa Hideaki Miyake Masato Fujisawa 《Journal of infection and chemotherapy》2013,19(2):211-216
During chemotherapy, patients are more susceptible to infectious complications as a result of bone marrow suppression, leading to neutropenia. The purpose of this study is to investigate risk factors for refractory febrile neutropenia (FN) during urological chemotherapy. Our method for suppressing FN is to use granulocyte colony-stimulating factor and prevent upper respiratory infection by masking and gargling. We studied 47 episodes of FN in 39 patients that occurred during urological chemotherapy for urothelial cancer, testicular cancer, and prostate cancer. Among our cases, there were 5 patients with refractory FN; we set risk factors for refractory FN and performed statistical analyses. The average age of the 39 patients was 60.6 years (range, 18–80 years). In 47 FN episodes, the chemotherapy regimen before the occurrence of FN included 15 (31.9 %) MVAC (methotrexate, vinblastine, adriamycin, cisplatin) for urothelial cancer, 5 (10.6 %) DE (docetaxel, estramustin) for prostate cancer, and 3 (6.4 %) TIP (paclitaxel, ifosfamide, cisplatin) for testicular cancer. The antibiotics used to treat FN included 17 (36.3 %) meropenem and 23 (49.0 %) cefepime, and the average duration of antibiotics was 4.4 days (range, 1–12). We investigated risk factors for refractory FN and showed a significant relationship between refractory FN and indwelling urinary catheter or smaller Multinational Association for Supportive Care in Cancer score by multivariate analysis. A future prospective study is needed for further evaluation for risk factors and establishing treatment protocols and guidelines for FN. 相似文献
48.
Yasufuku T Shigemura K Shirakawa T Nakano Y Tanaka K Arakawa S Kinoshita S Nishimura K Kawabata M Fujisawa M 《Scandinavian journal of infectious diseases》2011,43(2):83-88
As fluoroquinolone-resistant strains of Escherichia coli emerge, several risk factors for fluoroquinolone resistance have become evident, such as amino acid mutations in the quinolone resistance determining regions (QRDR) of gyrA and parC and previous use of fluoroquinolone. This study investigated risk factors for fluoroquinolone resistance and amino acid mutation in the QRDR in E. coli. We investigated the statistical correlation between each amino acid mutation and resistance to levofloxacin. We examined the minimum inhibitory concentration (MIC) of levofloxacin and the amino acid mutations of gyrA and parC by direct DNA sequence in E. coli clinically isolated from urinary tract infection (UTI) patients. We investigated risk factors for levofloxacin resistance, such as age, sex, and previous use of fluoroquinolone. We found a significant correlation between the number of mutations and resistance to levofloxacin (p < 0.001) and between the presence of underlying urinary tract disease and the presence of mutations (p = 0.004) by multivariate analyses. Three mutations in QRDR were demonstrated to be significantly correlated with levofloxacin resistance. In conclusion, these findings contribute to our understanding of the molecular mechanisms and risk factors for fluoroquinolone resistance. 相似文献
49.
50.
Kartagener syndrome (KS), an autosomal recessively inherited disease, is characterized by the triad of situs inversus, bronchiectasis and sinusitis. This disorder affects the activity of proteins important to the movement of cilia, especially in the respiratory tract and the spermatozoa, developing a series of systemic alterations, which can be diagnosed through radiographic examination. The aim of this paper is to describe a clinical case of this unusual pathology, including a brief literature review, emphasising the radiographic aspects of this pathology and stressing the importance of early diagnosis, which could be determined by an oral radiologist. 相似文献