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991.
Woo Jin Lee Chong Oon Park Seung Hwan Yoon Young Chae Chu 《Journal of Korean Neurosurgical Society》2010,48(5):461-464
The authors report a 58-year-old woman with low-grade fibromyxoid sarcoma primarily located in the right paravertebral area with extension to L4 neural foramen. The patient complained lower back pain with radiating pain along the posterolateral aspect of the right lower leg. She underwent subtotal surgical removal and Cyber Knife therapy. Diagnosis was made by strikingly characteristic microscopic appearance of a bland spindle cell sarcoma which contained numerous giant collagen rosettes and was also supported by immunohistological findings. The diagnostic image findings and literatures are reviewed and discussed. 相似文献
992.
通过建立胱肿瘤动物模型进一步研究其发生、发展、转移等变化的思路早已被研究者们所熟悉,而使用N-丁基-N-(4-羟丁基)亚硝胺是目前诱导膀胱肿瘤的最常用方法之一,采用的实验动物也不尽相同.本文介绍OH-BBN在不同鼠类中研究现状. 相似文献
993.
994.
Min Soon Kim PhD William N. Rodney Tara Cooper BA Chris Kite Gregory P. Reece MD Mia K. Markey PhD 《Journal of evaluation in clinical practice》2009,15(1):20-31
Rationale, aims and objectives Scarring is a significant cause of dissatisfaction for women who undergo breast surgery. Scar tissue may be clinically distinguished from normal skin by aberrant colour, rough surface texture, increased thickness (hypertrophy) and firmness. Colorimeters or spectrophotometers can be used to quantitatively assess scar colour, but they require direct patient interaction and can cost thousands of dollars. By comparison, digital photography is already in widespread use to document clinical outcomes and requires less patient interaction. Thus, assessment of scar coloration by digital photography is an attractive alternative. The goal of this study was to compare colour measurements obtained by digital photography and colorimetry. Methods Agreements between photographic and colorimetric measurements of colour were evaluated. Experimental conditions were controlled by performing measurements on artificial scars created by a make‐up artist. The colorimetric measurements of the artificial scars were compared with those reported in the literature for real scars in order to confirm the validity of this approach. We assessed the agreement between the colorimetric and photographic measurements of colour using a hypothesis test for equivalence, the intraclass correlation coefficient and the Bland–Altman method. Results Overall, good agreement was obtained for three parameters (L*a*b*) measured by colorimetry and photography from the results of three statistical analyses. Conclusion Colour measurements obtained by digital photography were equivalent to those obtained using colorimetry. Thus, digital photography is a reliable, cost‐effective measurement method of skin colour and should be further investigated for quantitative analysis of surgical outcomes. 相似文献
995.
综述了微孔塑料的性能特点和应用前景,从微孔塑料的单一相溶液的形成、微孔的成核和气泡的长大控制三个方面详细论述了微孔塑料的连续挤出成型的研究进展,并指出了当前的研究方向。 相似文献
996.
Christopher AKY Chong Ing-je Chen Gary Naglie Murray D. Krahn 《Journal of general internal medicine》2009,24(8):977-982
BACKGROUND Clinical practice guidelines (CPG) are meant to consider important values such as patient preferences.
OBJECTIVE To assess how well clinical practice guidelines (CPGs) integrate evidence on patient preferences compared with that on treatment
effectiveness.
DESIGN A cross-sectional review of a listing in 2006 of CPGs judged to be the best in their fields by an external joint government
and medical association body.
STUDY SELECTION Exclusion criterion was unavailability in electronic format. Sixty-five of 71 listed CPGs met selection criteria.
MEASUREMENTS Two instruments originally constructed to evaluate the overall quality of CPGs were adapted to specifically assess the quality
of integrating information on patient preference vs. treatment effectiveness. Counts of words and references in each CPG associated
with patient preferences vs. treatment effectiveness were performed. Two reviewers independently assessed each CPG.
MAIN RESULTS Based on our adapted instruments, CPGs scored significantly higher (p < 0.001) on the quality of integrating treatment effectiveness
compared with patient preferences evidence (mean instrument one scores on a scale of 0.25 to 1.00: 0.65 vs. 0.43; mean instrument
two scores on a scale of 0 to 1: 0.58 vs. 0.18). The average percentage of the total word count dedicated to treatment effectiveness
was 24.2% compared with 4.6% for patient preferences. The average percentage of references citing treatment effectiveness
evidence was 36.6% compared with 6.0% for patient preferences.
CONCLUSION High quality CPGs poorly integrate evidence on patient preferences. Barriers to incorporating preference evidence into CPGs
should be addressed.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
997.
前葡萄膜炎患者外周血细胞因子的研究 总被引:2,自引:0,他引:2
目的:通过分析细胞因子的性质,旨在探讨前葡萄膜炎可能的发病机制。方法:取20例HLA-B27相关前葡萄膜炎患者、20例小柳原田患者外周血和正常人作为对照组,通过酶联免疫反应(ELISA)检测患者外周血IFN-γ,IL-4和IL-10的含量。结果:两组患者外周血IFN-γ的含量较正常人显著增高(P<0.05),且小柳原田患者外周血中IFN-γ含量显著高于HLA-B27相关前葡萄膜炎患者外周血中IFN-γ含量(P<0.05)。结论:前葡萄膜炎发病机制可能和对自身抗原诱发的Th1型免疫反应过强有关。 相似文献
998.
舒芬太尼临床药动学研究及应用 总被引:5,自引:0,他引:5
目的 介绍舒芬太尼临床药动学及其在靶控输注中的应用.方法 阐述舒芬太尼血药浓度测定方法,总结近年来舒芬太尼临床药动学研究及其在靶控输注中的应用.结果 舒芬太尼给药后在体内呈一级动力学,常用三室模型描述人体内分布过程.年龄、体重、性别和肝、肾功能对舒芬太尼靶控输注的准确度影响较小.结论 靶控输注系统能精确预测舒芬太尼的血药浓度. 相似文献
999.
目的探讨长期使用安定类药物对失眠症患者日间功能和睡眠质量的影响。方法对35例长期使用安定类药物的老年失眠症患者(研究组)进行整夜多导睡眠图描记和日间功能问卷调查,并与30例未使用安定类药物的老年失眠症患者(对照组)对照分析。结果研究组和对照组日间功能异常者分别为91.4%和30.0%,两组差异有统计学意义(P〈0.05);多导睡眠图显示研究组睡眠潜伏期缩短、睡眠时间延长、浅睡眠增多、深睡眠和快速眼动期(REM)睡眠减少,与对照组比较差异有统计学意义(P〈0.01)。结论长期使用安定类药物可导致睡眠质量和日间功能下降。 相似文献
1000.
Chin-Liew Chong Shiu-Feng Huang Cheng-po Hu Ya-Ling Chen Hsin-Ying Chou Gar-Yang Chau Jin-Yuh Shew Yue-Lin Tsai Chiung-Tong Chen Chungming Chang Mong-Liang Chen 《Cancer epidemiology, biomarkers & prevention》2008,17(3):535-542
Previous studies have identified that the expression of UK114 is tissue specific and the protein has been found to be most abundant in liver and kidney. However, the expression of UK114 in human hepatocellular carcinoma and its relationship to differentiation and transformation of hepatocellular carcinoma have not been studied. In this study, the expression of UK114 in human hepatocellular carcinoma was examined by Northern and Western blot analyses. We found that UK114 was significantly down-regulated in most of hepatocellular carcinoma tissues compared with adjacent nontumor tissues (72.7%) at both mRNA and protein levels. We looked into the possibility that this decreased expression of UK114 in the hepatocellular carcinoma tissues may play a role in the differentiation or tumorigenicity of hepatocellular carcinoma. Immunohistochemical staining showed that the reduced expression of UK114 in hepatocellular carcinoma tissues was correlated with the tumor differentiation status as graded by the Edmondson-Steiner classification. On the other hand, overexpression of UK114 was not able to suppress the proliferation of human hepatoma cells and tumorigenicity in nude mice. These results suggest that UK114 does not seem to act as a tumor suppressor gene; however, it may useful as a biomarker that will assist in the grading of the differentiation status of hepatocellular carcinoma samples. 相似文献