全文获取类型
收费全文 | 1263篇 |
免费 | 62篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 28篇 |
妇产科学 | 25篇 |
基础医学 | 101篇 |
口腔科学 | 57篇 |
临床医学 | 100篇 |
内科学 | 451篇 |
皮肤病学 | 6篇 |
神经病学 | 71篇 |
特种医学 | 78篇 |
外科学 | 221篇 |
综合类 | 5篇 |
预防医学 | 29篇 |
眼科学 | 24篇 |
药学 | 41篇 |
肿瘤学 | 92篇 |
出版年
2023年 | 15篇 |
2022年 | 18篇 |
2021年 | 48篇 |
2020年 | 29篇 |
2019年 | 29篇 |
2018年 | 36篇 |
2017年 | 20篇 |
2016年 | 41篇 |
2015年 | 24篇 |
2014年 | 56篇 |
2013年 | 69篇 |
2012年 | 112篇 |
2011年 | 108篇 |
2010年 | 66篇 |
2009年 | 50篇 |
2008年 | 97篇 |
2007年 | 102篇 |
2006年 | 111篇 |
2005年 | 74篇 |
2004年 | 61篇 |
2003年 | 42篇 |
2002年 | 30篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 8篇 |
1998年 | 7篇 |
1997年 | 8篇 |
1996年 | 5篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1992年 | 2篇 |
1991年 | 6篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1987年 | 3篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1976年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1967年 | 1篇 |
1962年 | 1篇 |
1960年 | 1篇 |
1940年 | 2篇 |
排序方式: 共有1342条查询结果,搜索用时 15 毫秒
71.
Paediatric nephrolithiasis is quite challenging in terms of management because of the smaller size of the urinary tract and
the bigger risk for stone recurrence. Children bear a higher risk of metabolic and infectious causes of stone disease and
a longer lifetime risk for recurrence, especially in cases of residual fragments. Complete stone clearance should become the
absolute objective and clinically insignificant residual fragments should be avoided. Nowadays, percutaneous nephrolithotomy
(PCNL) arises as a logical first-line treatment option for considerable paediatric nephrolithiasis as miniaturization of endoscopes
and advances in energy sources for stone fragmentation have facilitated stone-free rates. In this review we present the evolution
of PCNL in children and we demonstrate its safety and efficacy. As appropriate instruments are available and relevant surgical
experience is accumulating, age should no longer exist as a limiting factor for performing PCNL. 相似文献
72.
73.
Manousakas T Kyriakou G Serafetinides E Giannopoulou M Kyroudi A Giannopoulos A 《Urology》2002,59(4):602
Congenital seminal vesicle cysts associated with renal agenesis are uncommon, but are currently detected more frequently with the use of sectional imaging procedures. Approximately 200 cases have been reported. The unique feature of our case is the combination of this disorder with an ipsilateral undescended testis. Our patient underwent partial vesiculectomy, in which the cyst was removed and the seminal vesicle remnant with its vas deferens was preserved. A review of the infertile cases and the impact of surgical treatment on fertility are discussed. Features that render partial vesiculectomy applicable and the potential effect of this procedure on fertility are highlighted. 相似文献
74.
75.
Pharmacokinetics of clarithromycin in the prostate: implications for the treatment of chronic abacterial prostatitis 总被引:2,自引:0,他引:2
Giannopoulos A Koratzanis G Giamarellos-Bourboulis EJ Panou C Adamakis I Giamarellou H 《The Journal of urology》2001,165(1):97-99
PURPOSE: We studied the pharmacokinetics of orally administered clarithromycin in prostatic tissue to define its role in the treatment of chronic abacterial prostatitis caused by intracellular pathogens. MATERIALS AND METHODS: A total of 45 men receiving 3 oral doses of 750 mg. clarithromycin at 12-hour intervals underwent suprapubic prostatectomy for benign prostate hyperplasia 4, 5, 6 and 7 hours after the last drug dose in 13, 12, 10 and 10 patients, respectively. Concentrations were determined in the prostate tissue and in plasma by an agar diffusion assay. RESULTS: A mean peak level of clarithromycin of 3.22 and 3.08 microg./gm. of tissue was achieved 4 hours after the third drug dose at the center and periphery of the adenoma, respectively. Tissue levels remained statistically superior to plasma levels at all intervals. CONCLUSIONS: The oral administration of clarithromycin achieved a prostate level much higher than the minimal inhibitory concentration of clarithromycin for the intracellular pathogens of chronic prostatitis. Thus, clarithromycin may be considered for treating chronic abacterial prostatitis. 相似文献
76.
Vassiliki Kotoula Sotirios Lakis Ioannis Tikas Eleni Giannoulatou Georgios Lazaridis Kyriaki Papadopoulou Kyriaki Manoussou Ioannis Efstratiou Alexios Papanikolaou Florentia Fostira Ioannis Vlachos Basil Tarlatzis George Fountzilas 《Gynecologic oncology》2019,152(2):375-386
Background
Tissue genomic heterogeneity (t-HET) in patients with epithelial ovarian cancer (OVCA) is related to tissue plasticity, i.e., flexibility to adapt to adverse molecular environments. Here, we interrogated the presence and clinical relevance of OVCA t-HET.Methods
We applied high-depth (>2000×) sequencing on 297 paraffin tissue samples (fallopian tubes, ovaries, intra-abdominal metastases) from 71 treatment-naïve patients who subsequently received first-line platinum-based chemotherapy. Based on tissue mutation patterns, we distinguished tissue genotypes into: no mutation (33/297 samples; 11.1%), stable (173; 58.2%) and unstable (91; 30.7%). We profiled genotypes per patient and assessed t-HET in 69 patients. Predicted pathogenic mutations refer to germline and/or tissues.Results
Among all 71 patients, 46 (64.8%) had pathogenic BRCA1 mutations and 15 (21.7%) had BRCA1/2 disruption (i.e., pathogenic mutations with position-LOH). We classified 29 patients with t-HET (42%), all with pathogenic BRCA1; t-HET was observed in 64% with such mutations (p?<?0.001). As opposed to non-t-HET, matched tissues in t-HET shared pathogenic BRCA1 (p?<?0.001) but not BRCA2 and TP53. Germline BRCA1 mutations in tissues exhibited position-LOH; heterozygous status; or, partial loss of the inherited allele accompanied by additional clonal mutations. Patients with t-HET had worse outcome (log-rank p?=?0.048 [progression-free]; p?=?0.037 [overall survival]), including 12/15 patients with disrupted BRCA1/2 and 3 BRCA1 carriers with partial germline loss in tissues.Conclusions
Pathogenic BRCA1 mutations appear necessary but may not be sufficient for the establishment of t-HET. t-HET may be associated with worse outcome, including in patients with disrupted BRCA1/2, which is usually considered as a favourable marker. OVCA t-HET may need to be addressed for treatment decisions. 相似文献77.
Thomas Makatsoris MD Haralabos P. Kalofonos Gerasimos Aravantinos Christos Papadimitriou Efstathios Kastritis Sotirios K. Rigatos Nikolaos Xiros Theodore Petsas Theofanis Economopoulos Athanassios K. Sakadamis George Fountzilas 《Journal of gastrointestinal cancer》2005,35(2):103-109
Background: Capecitabine and oxaliplatin are both effective and well-tolerated monotherapies for the treatment of advanced colorectal cancer (CRC). Oxaliplatin has also been shown to be very effective when combined with 5-FU/LV in the first-line setting. Aim of the Study: Assess the efficacy and safety of capecitabine plus oxaliplatin (XELOX) in patients with previously untreated advanced CRC. Methods: Fifty-three patients with measurable disease received capecitabine 1,000 mg/m2 twice daily on d 1–14 and oxaliplatin 130 mg/m2 on d 1, every 3 wk. Of these, 52 were evaluable for safety and 49 for antitumor response. Results: There was a low rate of grade 1/2 adverse events; grade 3/4 events included leukopenia (10%), neutropenia (6%), thrombocytopenia (2%), nausea/vomiting (4%), and diarrhea (4%). The overall response rate was 39% (95% CI, 25–54%) and median time to disease progression was 7.8 mo. Conclusions: XELOX is an active and well-tolerated first-line treatment for advanced CRC. Randomized phase III studies are ongoing to compare XELOX with FOLFOX in view of the comparable efficacy and safety but superior convenience of XELOX therapy. 相似文献
78.
Contrafouris CA Giannopoulos NM Chatzis AC Antoniades A Zavaropoulos PN Kirvassilis GV Kremastinos DT Sarris GE 《Journal of cardiac surgery》2005,20(5):460-462
Anomalous origin of the left coronary from the pulmonary artery (ALCAPA) is a rare congenital malformation, which may result in myocardial infarction, congestive heart failure, and sudden death if left untreated. Despite frequently advanced pathologic changes, there seems to be significant potential for the recovery of myocardial function in individuals with left ventricular dysfunction after the establishment of physiologic coronary circulation, particularly in the pediatric population. Reports of ALCAPA repair in adulthood are scarce and little information exists regarding the response of the left ventricle to revascularization in this age group. In this report, repair of ALCAPA in a significantly symptomatic adult patient with ventricular dysfunction is described, leading to an early recovery of left ventricular function. 相似文献
79.
Bile Duct Injuries Associated with Laparoscopic and Open Cholecystectomy: An 11-Year Experience in One Institute 总被引:7,自引:0,他引:7
Diamantis T Tsigris C Kiriakopoulos A Papalambros E Bramis J Michail P Felekouras E Griniatsos J Rosenberg T Kalahanis N Giannopoulos A Bakoyiannis C Bastounis E 《Surgery today》2005,35(10):841-845
Purpose Bile duct injury (BDI) represents the most serious complication of laparoscopic cholecystectomy (LC). The aim of this retrospective single-institution study was to evaluate the real incidence of BDI during laparoscopic and open cholecystectomy (OC) in a tertiary academic center in Athens, Greece.Methods Between January 1991 and December 2001, 3 637 patients underwent cholecystectomy in our department; as LC in 2 079 patients (LC group) and as OC in 1 558 patients (OC group). All the LCs were performed or supervised by five staff surgeons and all the OCs were performed or supervised by another five staff surgeons.Results There were 13 BDIs associated with LC (0.62%) and 6 associated with OC (0.38%) (P = 0.317). There was one death associated with BDI after LC. Only two (15.4%) of the BDIs associated with LC occurred within the proposed learning curve limit of 50 LCs per individual surgeon.Conclusion Laparoscopic cholecystectomy is safe and is not associated with a higher incidence of BDI than OC. Moreover, we did not find that the learning curve for LC affected BDI occurrence. 相似文献
80.
Congenital cardiac disease is recognized as a major predisposing substrate for infective endocarditis. We present three cases of unanticipated intraoperative discovery of vegetations in patients with congenital cardiac malformations without preoperative clinical, laboratory or echocardiographic evidence of infective endocarditis, and their successful treatment. The relevant literature is reviewed, with emphasis of the need to maintain a high index of suspicion for the presence of endocarditis during repair of congenital cardiac lesions. 相似文献