全文获取类型
收费全文 | 1436篇 |
免费 | 111篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 9篇 |
妇产科学 | 14篇 |
基础医学 | 235篇 |
口腔科学 | 31篇 |
临床医学 | 89篇 |
内科学 | 270篇 |
皮肤病学 | 93篇 |
神经病学 | 70篇 |
特种医学 | 73篇 |
外科学 | 273篇 |
综合类 | 15篇 |
一般理论 | 3篇 |
预防医学 | 79篇 |
眼科学 | 23篇 |
药学 | 95篇 |
中国医学 | 29篇 |
肿瘤学 | 127篇 |
出版年
2024年 | 1篇 |
2023年 | 14篇 |
2022年 | 39篇 |
2021年 | 58篇 |
2020年 | 39篇 |
2019年 | 42篇 |
2018年 | 70篇 |
2017年 | 45篇 |
2016年 | 59篇 |
2015年 | 72篇 |
2014年 | 82篇 |
2013年 | 111篇 |
2012年 | 150篇 |
2011年 | 98篇 |
2010年 | 55篇 |
2009年 | 34篇 |
2008年 | 80篇 |
2007年 | 75篇 |
2006年 | 67篇 |
2005年 | 67篇 |
2004年 | 64篇 |
2003年 | 56篇 |
2002年 | 40篇 |
2001年 | 19篇 |
2000年 | 15篇 |
1999年 | 11篇 |
1998年 | 3篇 |
1997年 | 6篇 |
1996年 | 7篇 |
1995年 | 8篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 7篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 8篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 5篇 |
1985年 | 2篇 |
1984年 | 6篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1968年 | 2篇 |
1944年 | 1篇 |
排序方式: 共有1556条查询结果,搜索用时 0 毫秒
121.
Glushkov AN Anosov MP Cherno SV Kostianko MV Larin SA Mun SA 《Klinicheskaia laboratornaia diagnostika》2008,(3):42-44
The study was undertaken to optimize the well known immunoassay of antibodies to chemical carcinogens, designed by J. Chagnaud et al., and examine the specific features of the generation of antibodies (Ab) to benzo[a]pyrene (BP) in patients with lung cancer. Ninety-two serum samples from healthy males and 80 samples from patients with lung cancer were studied. Increased efficiency was achieved by the use of bovine serum albumin instead of thyreoglobulin in the synthesis of carrier protein conjugates with BP. Better reproducibility was accomplished, by using the control serum sample with the known content of IgM, IgG, and IgA Ab to BP. Analysis of the study serum samples has established that in healthy male smokers, the count of IgA Ab was twice greater than that in non-smokers. The patients with lung cancer were found to higher levels of IgG and IgA Ab to BP (in both smokers and non-smokers) than healthy individuals. It is proposed to use the stated method to study a role of A to chemical carcinogens in the pathogenesis of malignancies. 相似文献
122.
Oh MS Yang WM Chang MS Park W Kim do R Lee HK Kim WN Park SK 《Journal of ethnopharmacology》2007,114(3):463-467
Rubi Fructus (RF), the dried, unripe fruit of Rubus coreanus M IQ. (Rosaceae), has been used to improve male reproductive function in traditional Korean medicine. In this study, we investigated the effects of RF on sperm parameters and expression of cAMP-responsive element modulator (CREM), which has a crucial role in spermatogenesis. RF was administered to 8-week-old male Wistar rats for 56 consecutive days (1.0 g/kg, daily, p.o.). Sperm analysis, RT-PCR, and Western blot assays were then carried out. The RF-treated animals showed significant increases in the weight of the testes, epididymal sperm count, and sperm motility compared to the control group. RF also increased the expression of CREM at both the mRNA and protein levels. These results suggest that RF may improve male fertility by enhancing spermatogenesis. 相似文献
123.
Radiofrequency Volume Reduction of Gastrocnemius Muscle Hypertrophy for Cosmetic Purposes 总被引:1,自引:1,他引:0
Park YJ Jo YW Bang SI Kim HJ Lim SY Mun GH Hyon WS Oh KS 《Aesthetic plastic surgery》2007,31(1):53-61
Muscularly prominent calves, caused mainly by hypertrophy of the gastrocnemius muscle (GCM), are prevalent among Asian women,
and this condition can be a significant factor leading to psychological stress. The authors have devised a method for contouring
the calf using radiofrequency (RF) applications to the GCMs to correct thick, muscular legs. This study was performed to investigate
the effects of RF energy in reducing enlarged GCMs for 250 patients (249 women and 1 man) who sought aesthetic consultation
for problems such as thick, muscular, asymmetric, or bowed calves. The operations were performed from June 2004 to April 2006.
The patients first received a local anesthetic and sedation. After application of RF current, the prominent muscular contours
improved, and the GCMs were contoured to an appropriate proportional volume. The range of the reductions in the calf circumferences
at their thickest levels was 1 to 6 cm (mean, 2.5 cm) during the follow-up visits 6 months after the procedures. Most of the
patients could return to their activities of daily living, except for exercise, after 1 to 7 days, and they were satisfied
with the improved aesthetic contour lines of their lower legs. Clinical photography and ultrasonic examination were performed,
and the leg circumferences were measured. Radiofrequency-induced coagulation tissue necrosis of the muscles caused no functional
disabilities, and the clinical improvement was well maintained after the treatments for up to 17 months of follow-up evaluation. 相似文献
124.
Increasing the number of breast cancer patients in follow-up involves increased costs and, with limited health care resources, there is a need to evaluate the cost-benefit to the patient of follow-up regimens. We present a randomized prospective study to evaluate the cost-benefit of intensive follow-up in the early detection of relapses in patients with breast cancer. One hundred and twenty-one patients were randomized to standard clinical follow-up (n=63) or to an intensive follow-up (n=58) that included diagnostic laboratory tests and imaging designed to detect early relapse following curative treatment. All patients had annual mammography. The number of scheduled outpatient appointments kept were 359 in the standard clinical follow-up and 355 in the intensive follow-up group. After a median of 3 years of follow-up, there were 28 relapses, 11 in standard clinical follow-up, and 13 in the intensive follow-up group. The overall cost of follow-up was 24,567 euros in the standard clinical follow-up group and 74,171 euros in the intensive follow-up group. Performing complimentary investigations in breast cancer follow-up is associated with higher costs without difference in early detection of relapses. 相似文献
125.
Hyunju Jin Hyun‐Ho Cho Won‐Jeong Kim Je‐Ho Mun Margaret Song Hoon‐Soo Kim Hyun‐Chang Ko Moon‐Bum Kim Hyojin Kim Byung‐Soo Kim 《The Journal of dermatology》2015,42(7):674-678
The clinical course of generalized pustular psoriasis (GPP) is variable and unpredictable. Sufficient data on the clinical course of the disease has not been reported due to its rarity. To investigate the clinical features and course of GPP according to its subtypes, medical records of patients diagnosed with GPP from 2002 to 2012 at two tertiary hospitals were reviewed. The data included patient demographics, associated symptoms, aggravating factors, patterns of relapse and prognosis. Thirty‐three patients with GPP were included in our study, with a mean age of 45.6 years and a male : female ratio of 1:1.2. Patients were categorized based on the following subtypes: acute GPP, 21 (63.6%); GPP of pregnancy, two (6.1%); juvenile GPP, three (9.1%); and annular GPP, seven (21.2%). In the acute GPP population, skin lesions cleared within 2 months in 11 (73.3%) patients, and six (40.0%) of these had no relapse. Severe complications, abortion or death, were observed in two patients (100.0%) with GPP of pregnancy. Nineteen (76.0%) of the GPP patients experienced persistence or relapse of skin lesions. The patterns of skin lesions upon relapse included plaques in six patients (31.6%), pustules in eight patients (42.1%), and plaques and pustules in five patients (26.3%). Among acute GPP patients, 16.7% of patients with no relapse had a history of plaque psoriasis. However, 77.8% of patients with persistence and relapse in their clinical course had a history of plaque psoriasis. In conclusion, our study presents the detailed clinical course of GPP by subtype in Korean patients. 相似文献
126.
127.
Je-Ho Mun Hyun-Je Park Hoon-Soo Kim Su-Han Kim Hyun-Chang Ko Byung-Soo Kim Moon-Bum Kim 《ANNALS OF DERMATOLOGY》2012,24(1):87-89
Lichens striatus (LS) is an acquired, self-limiting inflammatory dermatosis that follows the lines of Blaschko. The etiology of the eruption is unknown, but several theories have been proposed with focus on environmental factors, viral infection, cutaneous injury, hypersensitivity, and genetic predisposition. We describe a 19-year-old woman who developed a unilateral linear eruption 17 months after allogenic peripheral blood stem cell transplantation. Histopathology revealed features, which were consistent with LS. To the best of our knowledge, our patient is the first case describing the appearance of LS occurring after allogenic stem cell transplantation. We speculate that this condition represents an unusual form of localized, chronic graft-versus-host disease. 相似文献
128.
129.
130.
Ryeon Heo Minji Kang Seo-Yeong Mun Minju Park Eun-Taek Han Jin-Hee Han Wanjoo Chun Hongzoo Park Won-Kyo Jung Il-Whan Choi Won Sun Park 《Fundamental & clinical pharmacology》2023,37(1):75-84
We investigated the vasodilatory effect of omarigliptin, an oral antidiabetic drug in the dipeptidyl peptidase-4 inhibitor class, and its related mechanisms using phenylephrine (Phe)-induced pre-contracted aortic rings. Omarigliptin dilated aortic rings pre-constricted with Phe in a dose-dependent manner. Pretreatment with the voltage-dependent K+ channel inhibitor 4-aminopyridine significantly attenuated the vasodilatory effect of omarigliptin, whereas pretreatment with the inwardly rectifying K+ channel inhibitor Ba2+, ATP-sensitive K+ channel inhibitor glibenclamide, and large-conductance Ca2+-activated K+ channel inhibitor paxilline did not alter its vasodilation. Pretreatment with the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump inhibitors thapsigargin and cyclopiazonic acid significantly reduced the vasodilatory effect of omarigliptin. Neither cAMP/PKA-related signaling pathway inhibitors nor cGMP/PKG-related signaling pathway inhibitors modulated the vasodilatory effect of omarigliptin. Removal of endothelium did not diminish the vasodilatory effect of omarigliptin. Furthermore, pretreatment with the nitric oxide synthase inhibitor L-NAME or small-conductance Ca2+-activated K+ channel inhibitor apamin, together with the intermediate-conductance Ca2+-activated K+ channel inhibitor TRAM-34, did not influence the vasodilatory effect of omarigliptin. In conclusion, omarigliptin induced vasodilation in rabbit aortic smooth muscle by activating voltage-dependent K+ channels and the SERCA pump independently of other K+ channels, cAMP/PKA- and cGMP/PKG-related signaling pathways, and the endothelium. 相似文献