Dacryocysto-Rhinostomia interna nach West

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Protective effect of taurine against alendronate-induced gastric damage in rats

Alendronate (ALD) causes serious gastrointestinal adverse effects. The aim of this study was to investigate whether taurine (TAU), a semi-essential amino acid and an antioxidant, improves the alendronate-induced gastric injury. Rats were administered 20 mg/kg ALD by gavage for 4 days, either alone or following treatment with TAU (50 mg/kg, i.p.). On the last day of treatment, following drug administration, pylorus ligation was performed and 2 h later, rats were killed and stomachs were removed. Gastric acidity and tissue ulcer index values, lipid peroxidation and glutathione (GSH) levels, myeloperoxidase (MPO) activity as well as the histologic appearance of the stomach tissues were determined. Chronic oral administration of ALD induced significant gastric damage, increasing lipid peroxidation, MPO activity and collagen content, as well as decreasing tissue GSH levels. Treatment with TAU prevented the damage and also the changes in biochemical parameters. Findings of the present study suggest that ALD induces oxidative gastric damage by a local irritant effect, and that TAU ameliorates this damage by its antioxidant and/or membrane-stabilizing effects.     

Influence of Drain Placement on Postoperative Pain Following Laparoscopic Roux-en-Y Gastric Bypass for Morbid Obesity: Randomized Controlled Trial

Background

There is currently no evidence to support the routine use of an abdominal drain following laparoscopic Roux-en-Y gastric bypass (RYGB). Our aim was to investigate drain use in laparoscopic RYGB and its effects on postoperative pain.

Methods

Sixty-six patients were randomly divided into two groups as no-drain (n?=?36) and with-drain (n?=?30). Intraoperative (time, blood loss, complications) and postoperative outcomes (morbidities, pain scores, hospital stay) were compared.

Results

Demographics of both groups were comparable. Three patients in the no-drain group required a drain (8.3%). Median visual analog scale scores for days 1–3 for with-drain and no-drain groups were 4.5 (2–9) vs. 3 (0–8) (p?=?0.02), 3 (0–7) vs. 2 (0–7) (p?=?0.10), and 2 (0–7) vs. 0 (0–4) (p?=?0.0004), respectively. There was no difference between the groups in terms of complications and length of hospital stay.

Conclusion

Drain use increased the postoperative pain following laparoscopic RYGB. Drain placement following laparoscopic RYGB should be selective instead of a routine application.

     

Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults

There is concern about an emerging diabetes epidemic in Turkey. We aimed to determine the prevalence of diagnosed and undiagnosed diabetes, prediabetes and their 12-year trends and to identify risk factors for diabetes in the adult Turkish population. A cross-sectional, population-based survey, ‘TURDEP-II’ included 26,499 randomly sampled adults aged ≥ 20 years (response rate: 87 %). Fasting glucose and biochemical parameters were measured in all; then a OGTT was performed to identify diabetes and prediabetes in eligible participants. The prevalence of diabetes was 16.5 % (new 7.5 %), translating to 6.5 million adults with diabetes in Turkey. It was higher in women than men (p = 0.008). The age-standardized prevalence to the TURDEP-I population (performed in 1997–98) was 13.7 % (if same diagnostic definition was applied diabetes prevalence is calculated 11.4 %). The prevalence of isolated-IFG and impaired glucose tolerance (IGT), and combined prediabetes was 14.7, 7.9, and 8.2 %, respectively; and that of obesity 36 % and hypertension 31.4 %. Compared to TURDEP-I; the rate of increase for diabetes: 90 %, IGT: 106 %, obesity: 40 % and central obesity: 35 %, but hypertension decreased by 11 % during the last 12 years. In women age, waist, body mass index (BMI), hypertension, low education, and living environment; in men age, BMI, and hypertension were independently associated with an increased prevalence of diabetes. In women current smoking, and in men being single were associated with a reduced risk. These results from one of the largest nationally representative surveys carried out so far show that diabetes has rapidly become a major public health challenge in Turkey. The figures are alarming and underscore the urgent need for national programs to prevent diabetes, to manage the illness and thus prevent complications.     

Assessment of Metal Accumulation and Ecological Risk Around Rize Harbor, Turkey (Southeast Black Sea) Affected by Copper Ore Loading Operations by Using Different Sediment Indexes

The purpose of the study was to determine metal pollution and ecological risk in the sediments around Rize Harbor. Metal concentrations (Cu, Zn, Pb, Cd, As, Hg, Ni and Al), were determined in the sediments collected from 7 sites in November, 2010. Metal levels in the sediments were varied from 33.9 to 279.1 mg/kg for Cu, 82 to 383 mg/kg for Zn, 15.9 to 33 mg/kg for Pb, 4.9 to 12.3 mg/kg for As, 0.1 to 1.4 mg/kg for Cd, 0.01 to 0.07 mg/kg for Hg, 13.1 to 17.6 mg/kg for Ni, 1.5 % to 2.98 % for Al. Concentration of metals also was evaluated by enrichment factor, Sediment Quality Guideline (SQGs) of US EPA, and two sets of SQGs indices. A factor analysis was used to determine source of contamination. Two probable source types were identified as anthropogenic and crustal for metals, explaining 86.4 % of the total variance. Six sites were heavily polluted by Cu. Copper concentration in R1 station was found significant enrichment. Current concentration of copper would be expected to frequently be associated with the toxic effect on biota.     

Maturity-onset diabetes of the young (MODY)-related genetic variants in a Turkish patient cohort with early-onset diabetes: a cross-sectional study

International Journal of Diabetes in Developing Countries - There is no apparent data on the prevalence of maturity-onset diabetes of young (MODY) in adults in Turkey. We aimed to define the...     

Can Appropriate Diagnosis and Treatment of Childhood Asthma Reduce Excessive Antibiotic Usage?

Introduction

This study compared the frequency of antibiotic usage and the number of asthma episodes before and after the diagnosis and treatment of pediatric asthma patients who were followed up by specialists.

Subjects and Methods

Included in this study were 334 patients (211 males and 123 females) of 2–16 years of age who were diagnosed with asthma and followed up for at least 1 year in our clinic. The frequency of antibiotic usage and the number of asthma episodes in the year prior to diagnosis and treatment were compared to these same variables after 1 year of follow-up by specialists.

Results

The median age was 84 months (range: 24–192) and 212 (63s%) children were at school or in day care centers. Atopy and a family history of asthma were present in 200 (60s%) of the patients, and 137 (41s%) reported that at least one member of their household smoked. Antibiotics were used a median number of 7 times [interquartile range (IQR) = 6] in the year before the asthma diagnosis, and 2 times (IQR = 3) during the year after treatment (p < 0.001). The mean number of asthma episodes before diagnosis, i.e. 4 (IQR = 8) was reduced to 0 (IQR = 2) in the year after treatment when the patients were followed up by specialists (p < 0.001).

Conclusion

This study shows that appropriate diagnosis and treatment of childhood asthma significantly reduce the frequency of antibiotic usage and the number of asthmatic episodes.Key Words: Childhood, Asthma, Antibiotic usage