全文获取类型
收费全文 | 1155篇 |
免费 | 126篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 41篇 |
妇产科学 | 13篇 |
基础医学 | 226篇 |
口腔科学 | 10篇 |
临床医学 | 85篇 |
内科学 | 286篇 |
皮肤病学 | 45篇 |
神经病学 | 105篇 |
特种医学 | 31篇 |
外科学 | 182篇 |
综合类 | 20篇 |
预防医学 | 75篇 |
眼科学 | 33篇 |
药学 | 65篇 |
肿瘤学 | 49篇 |
出版年
2023年 | 6篇 |
2022年 | 12篇 |
2021年 | 24篇 |
2020年 | 13篇 |
2019年 | 31篇 |
2018年 | 30篇 |
2017年 | 30篇 |
2016年 | 31篇 |
2015年 | 24篇 |
2014年 | 36篇 |
2013年 | 53篇 |
2012年 | 60篇 |
2011年 | 57篇 |
2010年 | 50篇 |
2009年 | 39篇 |
2008年 | 49篇 |
2007年 | 31篇 |
2006年 | 61篇 |
2005年 | 68篇 |
2004年 | 50篇 |
2003年 | 41篇 |
2002年 | 53篇 |
2001年 | 65篇 |
2000年 | 53篇 |
1999年 | 44篇 |
1998年 | 10篇 |
1997年 | 11篇 |
1996年 | 13篇 |
1995年 | 7篇 |
1994年 | 6篇 |
1993年 | 5篇 |
1992年 | 16篇 |
1991年 | 17篇 |
1990年 | 21篇 |
1989年 | 16篇 |
1988年 | 11篇 |
1987年 | 15篇 |
1986年 | 6篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1979年 | 5篇 |
1977年 | 7篇 |
1976年 | 4篇 |
1975年 | 13篇 |
1973年 | 7篇 |
1972年 | 6篇 |
1971年 | 5篇 |
1970年 | 4篇 |
1969年 | 14篇 |
排序方式: 共有1281条查询结果,搜索用时 31 毫秒
31.
Saint S Lipsky BA Baker PD McDonald LL Ossenkop K 《Journal of the American Geriatrics Society》1999,47(12):1453-1457
OBJECTIVES: Urinary catheters are used frequently, but the relative risks and benefits of different types of devices are not clear. We sought to determine the beliefs of both older male patients and nursing staff about the relative merits and problems of condom and indwelling catheters. DESIGN: Patient and nurse survey using convenience sampling. SETTING: A University-affiliated Veterans Affairs medical center. PARTICIPANTS: Men hospitalized on medical, rehabilitation and nursing home units using either an indwelling or a condom catheter were invited to participate as were all members of the nursing staff on these units. Of 116 eligible patients, 104 were interviewed (response rate = 90%). Of 107 eligible nursing staff members, 99 completed the questionnaires (response rate = 92%). INTERVENTION AND MEASUREMENTS: Consenting patients were interviewed personally about their urinary catheter. The nursing staff were asked to complete a self-administered questionnaire. RESULTS: Patients were mostly older and predominantly hospitalized on the medical service. Compared with those using an indwelling catheter, patients using a condom catheter were more likely to believe that their catheter was comfortable (86 vs 58%, P = .04) and less likely to believe it was painful (14 vs 48%, P = .008) or to restrict their activity (24 vs 61%, P = .002). The nursing staff had a mean of 13 years nursing experience, and the majority worked in the nursing home unit. Most of the nursing staff respondents believed that condom catheters were less painful and restrictive for patients and were easier to apply, but they also believed that they fell off and leaked more often and required more nursing time. CONCLUSIONS: Both patients and nursing staff prefer condom to indwelling catheters for patient comfort, but they recognize that dislodgment and leaking are major drawbacks of condom catheters. A more secure condom catheter would greatly improve the management of male incontinence. 相似文献
32.
How Do Hospitalized Patients Feel About Resident Work Hours,Fatigue, and Discontinuity of Care? 下载免费PDF全文
Fletcher KE Wiest FC Halasyamani L Lin J Nelson V Kaufman SR Saint S Schapira M 《Journal of general internal medicine》2008,23(5):623-628
BACKGROUND: Patient-centered care requires that physicians understand patients' perspectives. Since the resident work hour rules were instituted, little information is available about how patients perceive these issues. Our objectives were to explore patients' knowledge, concerns, and attitudes about resident work hours, fatigue, and continuity of inpatient care and to evaluate the association between patients' trust and satisfaction with these concerns and attitudes. METHODS: We conducted a cross-sectional survey of 134 internal medicine inpatients at 3 institutions including a tertiary care academic health center, a Veterans Affairs medical center, and a private community teaching hospital. RESULTS: Mean age was 59 (range, 24-90), with 60% men and 70% white. Most patients agreed (50%) or felt neutral (38%) toward resident work hours being limited. Patients estimated that residents worked 60 h per week but thought that they should work no more than 51 h per week (p < .01 for the difference). Twenty-seven percent of patients had some concern about fatigue in the residents, and 28% reported concern about how often hand-offs of care occurred. Factor analysis yielded 3 factors: "worried about discontinuity/fatigue," "attitude toward resident/nurse work hours," and "perceived resident/nurse fatigue." In multivariable analyses, the "worried about fatigue/discontinuity" factor significantly predicted trust and satisfaction, and the "perceived resident/nurse fatigue" factor also predicted satisfaction. CONCLUSIONS: Some inpatients are concerned about both fatigue in resident physicians and discontinuity of care. This may play a role in trust and satisfaction for patients. Taking steps to design systems to minimize fatigue and discontinuity would be ideal. 相似文献
33.
Kevin Colclough Christine Bellanne‐Chantelot Cecile Saint‐Martin Sarah E. Flanagan Sian Ellard 《Human mutation》2013,34(5):669-685
Maturity‐onset diabetes of the young (MODY) is a monogenic disorder characterized by autosomal dominant inheritance of young‐onset (typically <25 years), noninsulin‐dependent diabetes due to defective insulin secretion. MODY is both clinically and genetically heterogeneous with mutations in at least 10 genes. Mutations in the HNF1A gene encoding hepatocyte nuclear factor‐1 alpha are the most common cause of MODY in most adult populations studied. The number of different pathogenic HNF1A mutations totals 414 in 1,247 families. Mutations in the HNF4A gene encoding hepatocyte nuclear factor‐4 alpha are a rarer cause of MODY with 103 different mutations reported in 173 families to date. Sensitivity to treatment with sulfonylurea tablets is a feature of both HNF1A and HNF4A mutations. The HNF4A MODY phenotype has been expanded by the reports of macrosomia in ~50% of babies, and more rarely, neonatal hyperinsulinemic hypoglycemia. The identification of an HNF1A or HNF4A gene mutation has important implications for clinical management in diabetes and pregnancy, but MODY is significantly underdiagnosed. Current research is focused on identifying biomarkers and developing probability models to identify those patients most likely to have MODY, until next generation sequencing technology enables cost‐effective gene analysis for all patients with young onset diabetes. 相似文献
34.
Frédérique Moreau Rachid Fetouchi Isabelle Micalessi Valérie Brejeon Nathalie Bacon Geert Jannes Catherine Le Pendeven Bouchra Lekbaby Dina Kremsdorf Jean Lacau Saint Guily Patrick Soussan 《Journal of clinical virology》2013,56(3):328-333
BackgroundDiagnosis of human papillomavirus (HPV) disease remains a challenge due to several factors related to the cost, the workload of available commercial assays to detect and genotype HPV, and to the low prevalence of infected patients.ObjectiveOur study aimed to develop a real-time PCR, based on SPF10 primers, in order to combine HPV-DNA detection and genotype identification avoiding the negative samples.Study designValidation of SYBR-green based SPF10 real-time PCR on HPV-DNA plasmids followed by the investigation of the viral status in 92 samples from oropharyngeal (94%) cutaneous biopsies (3%) and anal smears (3%) which had previously been HPV-genotyped by LiPA hybridization. In-house HPV viral loads were performed to evaluate the SPF10 real-time PCR sensitivity.ResultsData showed that 100% of HPV plasmids, assessable by LiPA hybridization, were detected and genotyped appropriately after SPF10 real-time PCR assays. These results defined a range of melting temperature peaks for HPV positivity by real-time PCR. The efficient determination of the presence of HPV-DNA by SPF10 real-time PCR was validated for 98% of clinical samples compared to commercial method. Discordant results were due to a low HPV-DNA amount and to a supplementary HPV genotype identified. The SPF10 real-time PCR sensitivity was evaluated between 1 and 10 copies/103 cells using in-house HPV (6, 11 and 16) viral load assays.ConclusionThe real-time PCR method was efficient in combining screening and genotyping of HPV-DNA. Cost and workload reduction by SPF10 real-time PCR approach may facilitate earlier diagnosis and clinical management of HPV infected patients. 相似文献
35.
Efficacy and tolerance of one‐third full dose bacillus Calmette–Guérin maintenance therapy every 3 months or 6 months: Two‐year results of URO‐BCG‐4 multicenter study 下载免费PDF全文
36.
Mario Iannaccone Mohamed Abdirashid Umberto Annone Gaëlle Saint‐Hilary Pascal Meier Alaide Chieffo Sl Chen Carlo di Mario Federico Conrotto Pierluigi Omed Antonio Montefusco Michele De Benedictis Sara Rettegno Baldassare Doronzo Mauro Gasparini Mauro Rinaldi Maurizio D'Amico Fabrizio D'Ascenzo 《Catheterization and cardiovascular interventions》2020,95(7):1259-1266
37.
38.
39.
Adil Ouzzane Pierre Colin Tarek P. Ghoneim Marc Zerbib Alexandre De La Taille François Audenet Fabien Saint Nicolas Hoarau Emilie Adam Marie Dominique Azemar Henri Bensadoun Luc Cormier Olivier Cussenot Alain Houlgatte Gilles Karsenty Charlotte Maurin François Xavier Nouhaud Véronique Phe Thomas Polguer Mathieu Roumiguié Alain Ruffion Morgan Rouprêt 《World journal of urology》2013,31(1):189-197