全文获取类型
收费全文 | 105篇 |
免费 | 5篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 18篇 |
基础医学 | 7篇 |
口腔科学 | 9篇 |
临床医学 | 11篇 |
内科学 | 36篇 |
神经病学 | 2篇 |
特种医学 | 2篇 |
外科学 | 6篇 |
综合类 | 3篇 |
预防医学 | 1篇 |
眼科学 | 2篇 |
肿瘤学 | 1篇 |
出版年
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2017年 | 2篇 |
2016年 | 2篇 |
2015年 | 4篇 |
2014年 | 3篇 |
2013年 | 4篇 |
2012年 | 17篇 |
2011年 | 10篇 |
2010年 | 7篇 |
2009年 | 4篇 |
2008年 | 11篇 |
2007年 | 5篇 |
2006年 | 8篇 |
2005年 | 8篇 |
2004年 | 8篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1996年 | 1篇 |
排序方式: 共有112条查询结果,搜索用时 0 毫秒
11.
Karabag T Aydin M Barut F Buyukates M Dogan SM Celik O Sayin MR 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2012,39(1):116-118
Lymphomatoid granulomatosis is a rare, diffuse, large B-cell lymphoma that is positive for Epstein-Barr virus. A multiorgan process, it manifests itself chiefly in the lungs but can also affect the skin, nervous system, and kidneys. Cardiac involvement and pericardial effusion are very unusual. We report the case of a 62-year-old man with lymphomatoid granulomatosis involving the heart and lungs. Diagnosis was confirmed with wedge biopsy at pericardiotomy, and the patient was treated with cyclophosphamide, prednisolone, and vincristine. Although the patient was still symptomatic at 6-month follow-up, he was in partial remission with improved functional capacity. 相似文献
12.
Murat Cakir Funda Ozgenc Masallah Baran Cigdem Arikan Murat Sezak Muge Tuncyurek Orkan Ergun Rasit Vural Yagci 《Rheumatology international》2010,30(4):531-534
Familial Mediterranean fever (FMF) is hereditary episodic febrile syndrome characterized by acute attacks of fever and serosal
inflammation, generally lasting 1–3 days and resolves spontaneously. Apart from abdominal pain, patients may present with
variety of abdominal manifestations such as acute peritonitis, mechanical intestinal obstruction, diarrhea, bowel infarction,
amyloidosis and small amounts of peritoneal fluid during the acute attacks. A 6-year-old boy was admitted with massive ascites.
After extensive laboratory investigations, no causative agent could be identified. On subsequent days, he developed fever
and skin eruptions. Acute-phase reactants were increased. A second tomography revealed cystic fluid collection near the anterior
side of spleen that invades the stomach. An exploratory was performed and histopathological examination of the all resected
specimens revealed mix inflammatory cell infiltrate associated with severe myofibroblast proliferation suggesting chronic
inflammatory process on the mesenteric region. A diagnosis of FMF was suspected based on the clinical, laboratory and histopathological
findings, and a trial of colchicine therapy initiated. Ascites and other serosal inflammations improved within 1 week without
any recurrence during the next 12-month period on colchicine treatment. Atypical presentations of FMF have been increasingly
reported. Pediatricians should keep FMF in mind in the differential diagnosis of massive ascites especially in regions where
hereditary inflammatory disease are common. 相似文献
13.
Osman Ersoy Rasit Aran Musa Aydinli Ozlem Yonem Ozgur Harmanci Bulent Akdogan Ahmet Pinar Cenk Sokmensuer Yusuf Bayraktar 《Indian journal of gastroenterology》2006,25(5):258-259
Intravesical bacillus Calmette-Guerin (BCG) is used in patients with urinary bladder carcinoma. Although it is generally well tolerated, granulomatous hepatitis is a rare but serious complication. We report a 42-year-old man and a 56-year-old man who developed granulomatous hepatitis following intravesical BCG. One of them was treated successfully with antitubercular therapy; the other died because of BCG sepsis and multi-organ failure. 相似文献
14.
Genel F Unal F Ozgenc F Aksu G Aydogdu S Kutukculer N Yagci RV 《Journal of gastroenterology and hepatology》2003,18(6):645-650
BACKGROUND: In the development of chronic hepatitis with hepatitis B virus infection and in response to therapy, the immune status of the infected host plays a critical role. In this study, immunological variables were assessed in patients before interferon alpha and lamivudine therapy to determine if any pretreatment immunological parameter could be an indicator of response to therapy in childhood chronic hepatitis B infection. METHODS: Forty-four patients with chronic hepatitis B virus infection, aged 9.0 +/- 3.9 years, were enrolled in the study. The pretreatment clinical features, biochemical test results, histological activity indexes and immunological parameters were evaluated. All patients received interferon alpha for 6 months and lamivudine for 52 weeks. Four patients who could not be followed up were excluded from the study. The other 40 patients have been followed for a mean period of 27.5 +/- 9.7 months after therapy discontinuation. RESULTS: Seventeen patients showed loss of hepatitis B early antigen (HBeAg) with appearance of anti-HBe (42.5%) and six of those who responded also showed loss of hepatitis B surface antigen (HBsAg) with the presence of anti-HBs (15%). Except elevated aspartate aminotransferase levels, there was no significantly correlation between response and sex, age, pretreatment duration of disease and histological activity indexes. Pretreatment immunoglobulins (Ig), IgG subclasses, complement C3, C4 and secretory IgA levels were also not found to be significantly related to response. The evaluation of lymphocyte subsets showed that therapy responders had significantly reduced pretreatment ratios of CD4/CD8+ lymphocytes due to prominent increased percentages of CD8+ cells. The other cellular immunity parameters and some cell surface adhesion molecules were similar in both groups. CONCLUSION: This study emphasizes the importance of increased pretreatment CD8+ lymphocyte percentages leading to a significant decrease in CD4/CD8 ratio in chronic hepatitis B virus infection of childhood as an immunological factor predicting response to treatment. 相似文献
15.
Aras C Ozdamar A Ergin S Ozturk R Midilli K Karacorlu M Ozkan S 《Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde》2005,219(2):93-96
PURPOSE: To assay the vitreous of asymptomatic hepatitis B virus (HBV) carriers for the presence of HBV DNA using polymerase chain reaction (PCR). METHODS: Vitreous and serum specimens were collected from 13 carriers of HBV. The presence of HBV DNA was investigated by using PCR and Digene's Hybrid Capture System. The presence of hepatitis B surface antigen (HBsAg) in vitreous was also investigated by using the enzyme immunoassay (EIA). RESULTS: The serum was positive for HBV DNA in3 of the 13 asymptomatic carriers using PCR. Vitreous samples of all the patients, including 3 patients who were positive for HBV DNA in serum, were negative for HBV DNA with PCR and were negative for HBsAg with EIA. CONCLUSION: There is no evidence of HBV in the vitreous of asymptomatic HBV carriers. 相似文献
16.
Rasit Cevizci Alper Dilci Fatih Celenk Recep Karamert Yildirim Bayazit 《Auris, nasus, larynx》2018,45(3):417-420
Objective
To evaluate the effects of otitis media with effusion on surgical parameters, patient safety, perioperative and postoperative complications.Methods
Total 890 children who underwent cochlear implantation between 2006 and 2015 were included. The ages ranged from 12 months to 63 months (mean: 32 months). The patients were divided into two groups according to the presence or absence of otitis media with effusion; otitis media with effusion group and non-otitis media group.Results
Of 890 children, 105 had otitis media with effusion prior to surgery. In non-otitis media with group, there were 785 children. The average duration of surgery was 60 min (ranged from 28 to 75 min) in non-otitis media group, and 90 min (ranged from 50 to 135 min) in otitis media with effusion group (p < 0.05). Granulation tissue and edematous middle ear and mastoid mucosa were observed in all cases of otitis media with effusion during the surgery. There was no significant difference between the complications of groups with or without otitis media with effusion (p > 0.05). In 5 of 105 patients, there was a ventilation tube inserted before cochlear implantation, which did not change the outcome of implantation.Conclusion
There is no need for surgical treatment for otitis media with effusion before implantation since otitis media with effusion does not increase the risks associated with cochlear implantation. Operation duration is longer in the presence of otitis media with effusion. However, otitis media with effusion leads to intraoperative difficulties like longer operation duration, bleeding, visualization of the round window membrane, cleansing the middle ear granulations as well as mastoid and petrous air cells. 相似文献17.
Arikan C Berdeli A Kilic M Tumgor G Yagci RV Aydogdu S 《Digestive diseases and sciences》2008,53(7):2000-2004
Inflammation is an important feature of biliary atresia, and recent studies suggest that its occurs in a genetically susceptible host. The intercellular adhesion molecule-1 (ICAM-1) is of paramount importance for the initiation and propagation of various inflammatory conditions. AIM: To determine whether the Glu241Arg polymorphism in the ICAM-1 gene, which impairs inflammatory responses, is associated with biliary atresia. METHODS: Between February 2002 and November 2004, 19 patients (mean age 1 +/- 0.4 years) diagnosed as biliary atresia were included in the study. Thirty-eight children with chronic liver disease and a group of unrelated healthy controls (n = 123) included in this study. After informed consent, blood was collected and genomic DNA was obtained. Genotyping was performed by amplification-refractory mutation system polymerase chain reaction (ARMSPCR). Associations were assessed by using Fischer's exact test. RESULTS: ICAM G242R A allele frequency was significantly higher in the BA group than in both the CLD and healthy control groups (OR = 4.4, 95 CI% 1.3-15.1, P = 0.03 and OR = 4.8 CI% 1.5-15.6, P = 0.01, respectively). Univariate analysis showed that polymorphism of ICAM G241R polymorphism was significantly related to biliary atresia. There was not significant correlation between PELD score and ICAM-1 genotypes both in BA and CLD groups. CONCLUSION: These findings provide evidence for the possible role of ICAM-1 241R polymorphism in BA pathogenesis. 相似文献
18.
19.
20.