全文获取类型
| 收费全文 | 2416541篇 |
| 免费 | 180322篇 |
| 国内免费 | 4106篇 |
专业分类
| 耳鼻咽喉 | 34614篇 |
| 儿科学 | 73576篇 |
| 妇产科学 | 63472篇 |
| 基础医学 | 337868篇 |
| 口腔科学 | 68021篇 |
| 临床医学 | 218402篇 |
| 内科学 | 473289篇 |
| 皮肤病学 | 48408篇 |
| 神经病学 | 203457篇 |
| 特种医学 | 96473篇 |
| 外国民族医学 | 891篇 |
| 外科学 | 363494篇 |
| 综合类 | 56505篇 |
| 现状与发展 | 1篇 |
| 一般理论 | 1045篇 |
| 预防医学 | 193934篇 |
| 眼科学 | 55899篇 |
| 药学 | 178956篇 |
| 59篇 | |
| 中国医学 | 4408篇 |
| 肿瘤学 | 128197篇 |
出版年
| 2018年 | 25057篇 |
| 2017年 | 19435篇 |
| 2016年 | 21309篇 |
| 2015年 | 23976篇 |
| 2014年 | 34401篇 |
| 2013年 | 52051篇 |
| 2012年 | 70226篇 |
| 2011年 | 73804篇 |
| 2010年 | 43295篇 |
| 2009年 | 41528篇 |
| 2008年 | 69863篇 |
| 2007年 | 74347篇 |
| 2006年 | 75006篇 |
| 2005年 | 72999篇 |
| 2004年 | 70209篇 |
| 2003年 | 67773篇 |
| 2002年 | 66889篇 |
| 2001年 | 112619篇 |
| 2000年 | 116688篇 |
| 1999年 | 98483篇 |
| 1998年 | 28012篇 |
| 1997年 | 25646篇 |
| 1996年 | 25532篇 |
| 1995年 | 24700篇 |
| 1994年 | 23232篇 |
| 1993年 | 21644篇 |
| 1992年 | 79538篇 |
| 1991年 | 76527篇 |
| 1990年 | 73686篇 |
| 1989年 | 70955篇 |
| 1988年 | 65926篇 |
| 1987年 | 64912篇 |
| 1986年 | 61441篇 |
| 1985年 | 58516篇 |
| 1984年 | 44315篇 |
| 1983年 | 37736篇 |
| 1982年 | 22963篇 |
| 1981年 | 20403篇 |
| 1979年 | 41384篇 |
| 1978年 | 29053篇 |
| 1977年 | 24407篇 |
| 1976年 | 22901篇 |
| 1975年 | 24022篇 |
| 1974年 | 29694篇 |
| 1973年 | 28107篇 |
| 1972年 | 26285篇 |
| 1971年 | 24217篇 |
| 1970年 | 22798篇 |
| 1969年 | 21130篇 |
| 1968年 | 19160篇 |
排序方式： 共有10000条查询结果，搜索用时 15 毫秒
101.
N. Guiso J.-L. Gallais G. Gavazzi D. Pinquier J. Gaillat 《Médecine et maladies infectieuses》2018,48(1):30-36
Objective
To assess the incidence of pertussis (whooping cough) in subjects aged 50 years and older in France.Methods
Participating family physicians (FPs) using the patient record management software AxiSanté® included patients aged 50 years and older, who had signed an informed consent form, presenting with persistent cough for 7 to 21 days. Bordetella genetic material was detected by polymerase chain reaction (PCR) on nasopharyngeal samples collected at the FP's discretion.Results
A total of 42 FPs included 129 patients from June 2013 to August 2014 (large cities: 38; medium-sized cities: 57; rural areas: 34); 106 samples were analyzed. Overall, 30 pertussis cases were diagnosed: 10 cases confirmed by PCR, 18 purely clinical cases, and two direct epidemiological cases. The crude incidence rate per 100,000 patients aged ≥ 50 years was 103.6 (95% CI: 69.9–47.9): 77.1 in large cities, 103.1 in medium-sized cities, and 143.9 in rural areas. The extrapolated incidence rate per 100,000 persons aged ≥ 50 years was 187.1 (95% CI: 126.2–67.1): 131.1 in large cities, 256.1 in medium-sized cities, and 242.2 in rural areas.Conclusion
The population aged 50 years and older can serve as a reservoir. Its role in Bordetella pertussis circulation should be taken into account for pertussis booster vaccination programs. 相似文献102.
103.
104.
105.
Jérémy Lardon Florelle Bellet Rim Aboukhamis Hadyl Asfari Julien Souvignet Marie-Christine Jaulent 《Expert opinion on drug safety》2018,17(8):763-774
Background: Social media are currently considered as a potential complementary source of knowledge for drug safety surveillance. Our primary objective was to estimate the frequency of adverse drug reactions (ADRs) experienced by Twitter users. Our secondary objective was to determine whether tweets constitute a valuable and informative source of data for pharmacovigilance purposes, despite limitations on character number per tweet.
Research design and methods: We selected a list of 33 drugs subject to careful monitoring due to safety concern in France and Europe, and extracted tweets using the streaming API from 30 September 2014 to 5 April 2015. Two pharmacovigilance centers classified these tweets manually as potential ADR case reports.
Results: Among 10,534 tweets, 848 (8.05%) implied or mentioned an ADR without meeting the four FDA criteria required for reporting an ADR, and 289 (2.74%) tweets were classified as ‘case reports.’ Among them 20 (7.27%) tweets mentioned an unexpected ADR and 33 (11.42%) tweets mentioned a serious ADR.
Conclusions: With the use of dedicated tools, Twitter could become a complementary source of information for pharmacovigilance, despite a major limitation regarding causality assessment of ADRs in individual tweets, which may improve with the new limitation to 280 characters per tweet. 相似文献
106.
107.
108.
Michael Bitonti Payal Patel Rebecca Dickinson Peter Knapp Susan J. Blalock 《Research in social & administrative pharmacy》2018,14(3):295-302
Background
Poor medication adherence is an ongoing issue, and contributes to increased hospitalizations and healthcare costs. Although most adverse effects are rare, the perceived risk of adverse effects may contribute to low adherence rates.Objectives
The objective of this study was to determine how adverse effect likelihood and pharmacist counseling on adverse effect prevention affects individuals': (1) willingness to use a hypothetical medication and (2) perceptions of medication safety.Methods
This study used a 3 × 3 experimental design. Participants (n = 601) viewed a hypothetical scenario asking them to imagine being prescribed an anti-asthma medication that could cause fungal infections of the throat. Participants were randomized to 1 of 9 scenarios that differed on: probability of developing an infection (5%, 20%, no probability mentioned) and whether they were told how to reduce the risk of infection (no prevention strategy discussed, prevention strategy discussed, prevention strategy discussed with explanation for how it works). Participants were recruited through Amazon Mechanical Turk.Results
Participants were less willing to take the medication (F = 12.86, p < 0.0001) and considered it less safe (F = 13.11, p < 0.0001) when the probability of fungal infection was presented as 20% compared to 5% or when no probability information was given. Participants were more willing to take the medication (F = 11.78, p < 0.0001) and considered it safer (F = 11.17, p < 0.0001) when a prevention strategy was given. Finally, there was a non-statistically significant interaction between the probability and prevention strategy information such that provision of prevention information reduced the effect of variation in the probability of infection on both willingness to use the medication and perceived medication safety.Conclusions
Optimal risk communication involves more than informing patients about possible adverse effects. Pharmacists could potentially improve patient acceptance of therapeutic recommendations, and allay medication safety concerns, by counseling about strategies patients can implement to reduce the perceived risk of adverse effects. 相似文献109.
110.