全文获取类型
收费全文 | 123篇 |
免费 | 2篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 6篇 |
基础医学 | 24篇 |
临床医学 | 11篇 |
内科学 | 45篇 |
皮肤病学 | 5篇 |
神经病学 | 2篇 |
特种医学 | 5篇 |
外科学 | 3篇 |
综合类 | 8篇 |
预防医学 | 4篇 |
药学 | 5篇 |
中国医学 | 1篇 |
肿瘤学 | 3篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 2篇 |
2012年 | 4篇 |
2011年 | 6篇 |
2010年 | 2篇 |
2009年 | 3篇 |
2008年 | 4篇 |
2007年 | 16篇 |
2006年 | 6篇 |
2005年 | 3篇 |
2004年 | 6篇 |
2003年 | 3篇 |
2002年 | 3篇 |
2000年 | 1篇 |
1998年 | 8篇 |
1997年 | 6篇 |
1996年 | 1篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1972年 | 3篇 |
1971年 | 1篇 |
1969年 | 2篇 |
1968年 | 3篇 |
1967年 | 2篇 |
1966年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有126条查询结果,搜索用时 15 毫秒
21.
22.
It would appear that it has become almost common practice to regard arachidonic acid (AA) as the sole precursor of eicosanoids. The fact that both dihomogamma-linolenic acid (DGLA) and eicosapentaenoic acid (EPA) give rise to distinct families of eicosanoids is commonly almost completely ignored. Elevated tissue levels of AA eicosanoids have been found in and have been implicated in the etiology of a number of diseases. Drugs which selectively block AA mobilization or its eicosanoid metabolism have therefore been developed for therapeutic use in these conditions. The fact that such drugs will also simultaneously block the eicosanoid metabolism from DGLA as well as from EPA is also commonly ignored. It is suggested that the profoundly adverse side-effects displayed by some of these drugs, resulting in some instances in their withdrawal from use, could be the direct result of their concomitant action of interfering with the eicosanoid metabolism of DGLA and EPA. It is further suggested that, before the interactions between the eicosanoids derived from AA and those derived from DGLA and EPA are understood, the use of drugs for the manipulation of AA eicosanoid metabolism in isolation, could be hazardous. This implies that all such drugs currently in use are to be regarded as experimental and provisionally toxic in terms of their effects on the whole system of eicosanoid metabolism. Thus even drugs which have been passed by the FDA and similar Drug Control Councils require total re-evaluation especially in view of the fact that the non-steroidal anti-inflammatory drugs are often prescribed for chronic conditions which require therapy for several years.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
23.
The paper contains consideration of the problem of compliance to treatment of arterial hypertension and ischemic heart disease. Various aspects of compliance to treatment related to patients, physicians, special features of diseases and character of drug and nondrug recommendations. 相似文献
24.
The paper presents first results of the conducted in Russia large-scale study < REgularnoye Letcheniye I ProPHylaktika (Regular Treatment and Prevention) - the key to improvement of situation with cardiovascular diseases in Russia - RELIPH > on assessment of conformity of recommended by medical practitioners treatment of arterial hypertension (AH) and ischemic heart disease (IHD) to contemporary standards and compliance of patients to physician s recommendations. Local physicians/general practitioners (n=512) and their patients (n=2517) with AH and IHD from 20 cities of Russia participated in the study. The publication contains data on prevalence of risk factors in patients with AH and IHD, their knowledge, habits, skills, and amount of possessed medical information, as well as awareness of primary care physicians about actual problems of secondary prevention of cardiovascular diseases. 相似文献
25.
26.
Total obstruction of the airways caused all respiratory efforts to stop on 15 occasions in 10 preterm babies. This was not seen in 60 studies on 38 term babies. These findings suggest that failure to achieve an oral airway may not be the only mechanism by which upper airway obstruction might cause the cot death syndrome. 相似文献
27.
28.
Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone 总被引:5,自引:8,他引:5
Messinis IE; Milingos S; Zikopoulos K; Kollios G; Seferiadis K; Lolis D 《Human reproduction (Oxford, England)》1998,13(5):1152-1156
It has been reported that oestradiol may play a role in the production of
leptin from adipocytes. To investigate this relationship further, nine
normally ovulating women were studied during two menstrual cycles, i.e. an
untreated spontaneous cycle and a cycle treated with follicle stimulating
hormone (FSH) from cycle day 2 until the day of human chorionic
gonadotrophin (HCG) injection. Serum leptin values on cycle day 2 did not
differ significantly between the spontaneous and the FSH cycles. In the
spontaneous cycles, leptin values declined gradually and significantly up
to day 7 and then increased progressively up to the day of luteinizing
hormone (LH) surge onset, at which point they achieved the highest values.
In the FSH cycles, serum leptin values increased gradually and
significantly up to day 6, remaining stable thereafter, and were in the
midfollicular phase significantly higher than in the spontaneous cycles.
Significant positive correlations were found between mean values of leptin
and mean values of oestradiol during the second half of the follicular
phase in the spontaneous cycles and during the first half in the FSH
cycles. A significant negative correlation was found between these two
parameters in the spontaneous cycles during the first half of the
follicular phase. Serum leptin levels were significantly higher in the
midluteal than in the follicular phase in both cycles. These results
demonstrate for the first time significant changes in leptin values during
the follicular phase of the human menstrual cycle and a significant
increase during superovulation induction with FSH. It is suggested that
oestradiol may be involved in the regulation of leptin production in women.
相似文献
29.
Great progress has been achieved during the last 20 years inthe field of ovulation induction in patients with polycysticovary syndrome (PCOS). Clomiphene citrate remains the firstline of treatment for all anovulatory women with PCOS, sincein properly selected patients the cumulative pregnancy rateapproaches that in normal women. Human urinary gonadotrophinshave been used extensively for ovulation induction but the developmentof low-dose regimens has opened a new era in the managementof anovulation related to PCOS. This article discusses the mainadvantages and disadvantages of the principal methods and regimenscurrently used for ovulation induction in patients with PCOSincluding clomiphene citrate, gonadotrophins, pulsatile gonadotrophin-releasinghormone (GnRH) and GnRH agonists. It also discusses new drugsdiscovered recently, particularly recombinant gonadotrophinsand GnRH antagonists, and provides some thoughts regarding theiruse in future protocols. Finally, based on the discovery ofnew ovarian substances which specifically control luteinizinghormone (LH) secretion, this article develops assumptions onpossible implications of these substances in the pathophysiologyof PCOS and their potential use in the management of the syndrome. 相似文献
30.