全文获取类型
收费全文 | 615篇 |
免费 | 33篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 18篇 |
妇产科学 | 5篇 |
基础医学 | 71篇 |
口腔科学 | 15篇 |
临床医学 | 29篇 |
内科学 | 166篇 |
皮肤病学 | 13篇 |
神经病学 | 13篇 |
特种医学 | 24篇 |
外科学 | 118篇 |
预防医学 | 33篇 |
眼科学 | 20篇 |
药学 | 75篇 |
中国医学 | 3篇 |
肿瘤学 | 49篇 |
出版年
2023年 | 3篇 |
2022年 | 9篇 |
2021年 | 20篇 |
2020年 | 15篇 |
2019年 | 20篇 |
2018年 | 43篇 |
2017年 | 28篇 |
2016年 | 13篇 |
2015年 | 15篇 |
2014年 | 22篇 |
2013年 | 29篇 |
2012年 | 45篇 |
2011年 | 55篇 |
2010年 | 23篇 |
2009年 | 20篇 |
2008年 | 31篇 |
2007年 | 22篇 |
2006年 | 26篇 |
2005年 | 23篇 |
2004年 | 19篇 |
2003年 | 22篇 |
2002年 | 11篇 |
2001年 | 14篇 |
2000年 | 17篇 |
1999年 | 6篇 |
1998年 | 6篇 |
1997年 | 2篇 |
1995年 | 3篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 6篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 4篇 |
1988年 | 4篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1979年 | 3篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1969年 | 6篇 |
1967年 | 3篇 |
1966年 | 1篇 |
1965年 | 4篇 |
1963年 | 1篇 |
排序方式: 共有656条查询结果,搜索用时 15 毫秒
651.
652.
653.
654.
Laure Sayyed Kassem Aman Rajpal Margarita Victoria Barreiro Faramarz Ismail-Beigi 《Journal of Diabetes》2023,15(10):817-837
Type 2 diabetes (T2DM) is a complex metabolic disorder manifested by hyperglycemia, insulin resistance, and deteriorating beta-cell function. A way to prevent progression of the disease might be to enhance beta-cell function and insulin secretion. However, most previous studies examined beta-cell function while patients were using glycemia-lowering agents without an adequate period off medications (washout). In the present review we focus on studies with a washout period. We performed a literature search (2010 to June 2021) using beta-cell function and enhancement. The evidence shows that beta-cell function can be enhanced. Bariatric surgery and very low calorie diets show improvement in beta-cell function in many individuals. In addition, use of glucagon-like peptide-1 receptor agonists for prolonged periods (3 years or more) can also lead to improvement of beta-cell function. Further research is needed to understand the mechanisms leading to improved beta-cell function and identify agents that could enhance beta-cell function in patients with T2DM. 相似文献
655.
Thibault Lenormand MD Kassem Abou Khalil MD Alexandre Bodin MD Dominique Babuty MD PhD Arnaud Bisson MD Nicolas Clementy MD PhD 《Journal of cardiovascular electrophysiology》2023,34(8):1730-1737
Introduction
The efficacy and safety of leadless cardiac pacemakers (LPMs) as an alternative to conventional transvenous cardiac pacing have been largely reported. The first generation of the MicraTM transcatheter pacing system (VR; Medtronic) was able to provide single-chamber VVI(R) pacing mode only, with a potential risk of pacemaker syndrome in sinus rhythm patients. A second-generation system (AV) now provides atrioventricular synchrony through atrial mechanical (Am) sensing capability (VDD mode).Objective
We sought to compare VR and AV systems in sinus rhythm patients with chronic ventricular pacing (Vp) for complete atrioventricular block.Methods
All consecutive patients implanted with an LPM in our department for complete atrioventricular block were retrospectively screened. Patients with atrial fibrillation, sinus dysfunction, or Vp burden <20% at 1 month postimplantation were excluded. Patients were systematically followed with a visit at 1 month, and then at least once a year.Results
A total of 93 patients—45 VR (2015–2020) and 48 AV (2020–2021)—were included. VR and AV patients had similar baseline characteristics, except for VR patients being older (80 ± 8 vs. 77 ± 9 years, p = 0.049). The mean Vp burden was 77% in the VR and 82% in the AV group (p = 0.38). In AV patients, the median AV synchronous beats rate was 78%, with 65% having a >66% rate. An E/A ratio <1.2 as measured on echocardiography was the only independent predictor of accurate atrial mechanical tracking (p = 0.01). One-year survival rate was similar in both groups. Five patients in the VR and 0 in the AV group eventually developed pacemaker syndrome within 1 year post-implantation (p = 0.02).Conclusion
In sinus rhythm patients with chronic Vp for complete atrioventricular block implanted with an LPM, the atrial mechanical sensing algorithm allowed significant atrioventricular synchrony in most patients and was associated with no occurrence of—otherwise rare—pacemaker syndrome. 相似文献656.
Gaelle Fiard MD PhD Cecilia Hughes PhD Redha Heus PhD Bruno Abert MSc Emilie Chipon PhD Isabelle Boudry MSc Geraldine Saada-Sebag MD Maysoun Kassem MD Cecilia Lanchon MD Jean-Alexandre Long MD PhD Jean-Luc Descotes MD PhD Alexandre Moreau-Gaudry PhD Sandrine Voros PhD 《Lasers in surgery and medicine》2023,55(2):226-232