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21.
M. E. Perry Y. Mustafa S. K. Wood M. I. D. Cawley D. C. Dumonde K. A. Brown 《Rheumatology international》1997,17(4):169-174
A morphological examination of synovial tissue from 25 patients with rheumatoid arthritis revealed that binucleated or multinucleated
plasma cells were present in all samples and absent in synovia obtained from 16 control patients. Plasma cells containing
two, three of four nuclei constitutet a mean 3% of the total plasma cell population. They were aways found amongst plasma
cell infiltrates and in close association with small blood vessels. Ultrastructural analysis found no evidence of cellular
membranes separating the individual nuclei in binucleated or multinucleated plasma cells, suggesting that the cells did not
arise from fusion. Some of these plasma cells had a diameter approaching 100 μm, and many were in intimate contact with macrophages.
The demonstration of a few cells with mitotic figures within the infiltrates suggests that the maintenance of plasma cell
numbers in rheumatoid synovium may depend, in part, upon their local proliferation.
Received: 25 August 1997 / Accepted: 2 October 1997 相似文献
22.
Formulation and in Vitro-in Vivo Evaluation of Sustained-Release Lithium Carbonate Tablets 总被引:1,自引:0,他引:1
Çiftçi Kadriye Çapan Yilmaz Öztürk Orhan Hincal A. Atilla 《Pharmaceutical research》1990,7(4):359-363
The release of lithium carbonate incorporated into polymethylmethacrylate, poly vinyl chloride, hy-drogenated vegetable oil, and carbomer matrix tablets was studied in vitro. The formulation containing 10% carbomer showed a sustained-release profile comparable to that of a standard, commercially available, sustained-release preparation containing 400 mg lithium carbonate embedded in a composite material. In vivo the newly formulated and standard sustained-release lithium carbonate tablets were compared to an oral solution and conventional lithium carbonate tablets in 12 healthy subjects. These crossover studies showed that the sustained-release tablets produced a flatter serum concentration curve than the oral solution and conventional tablet, without loss of total bioavailability. 相似文献
23.
Erkan Yildirim Erkan Kaptanoglu Kanat Ozisik Ethem Beskonakli Ozerk Okutan Mustafa F Sargon Kamer Kilinc Unal Sakinci 《European journal of cardio-thoracic surgery》2004,25(4):523-529
OBJECTIVE: We aimed to demonstrate the time-dependent ultrastructural changes in pneumocyte type II cells following brain injury, and to propose an electron microscopic scoring model for the damage. METHODS: Forty Wistar-Albino female rats weighing 170-200 g were used. The rats were allocated into five groups. The first group was the control and the second was the craniotomy without trauma. The others were trauma groups. Weight-drop method was used for achieving head trauma. Samples were obtained from the right and left pulmonary lobes at 2-, 8-, and 24-h intervals after transcardiac perfusion. An electron microscopic scoring model was used to reveal the changes. RESULTS: There were no ultrastructural pathological findings pointing to lung injury in any rat of the control groups. There was intense intracellular oedema in type II pneumocyte and interstitial oedema in the adjacent tissue in trauma groups. Oedema in mitochondria and dilatation in both smooth endoplasmic reticulum and Golgi apparatus was more evident in the 8- and 24-h trauma groups. The chromatin dispersion was disintegrated in the nucleus in all trauma groups. Scores of all trauma groups were significantly different from the controls (P<0.05). All trauma groups were different from each other at significant levels (P<0.05 for each trauma groups). CONCLUSIONS: The data suggested that ultrastructural damage is obvious at 2 h and deteriorates with time. The electron microscopic scoring model worked well in depicting the traumatic changes, which were supported by lipid peroxidation. Further experiments are needed to determine the exact outcome after brain death model. 相似文献
24.
Christoph R?cken Jutta Ernst Ernst Hund Hartmut Michels Jolanta Perz Wolfgang Saeger Orhan Sezer Simone Spuler Friedrich Willig und Hartmut H.-J. Schmidt 《Medizinische Klinik》2006,101(10):825-829
Ohne Zusammenfassung 相似文献
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27.
Gülin Vural Mustafa Ünlü Tamer Atasever Izlem Özur Ayşegül Özdemir Nahide Gökçora 《European journal of nuclear medicine and molecular imaging》1997,24(3):312-315
Indium-111 octreotide and thallium-201 scintigraphic studies were compared in 21 patients (16 with palpable and five with non-palpable lesions) suspected of having breast malignancies on the basis of mammography. Early (15 min) and late (3 h)201Tl (111 MBq) and 4-h and 24-h111In-octreotide (111–148 MBq) static planar anterior images (matrix 256×256) were obtained on separate days. Images were evaluated both visually and quantitatively. Biopsy was performed following the imaging studies. Histopathology revealed 17 breast carcinomas (15 cases of invasive ductal carcinoma, one mucinous adenocarcinoma and one intraductal carcinoma) and four benign breast lesions (two fibroadenomas, one abscess and one case of fat necrosis). The means histopathologcial tumour size (mean largest diameter) was 3.38±1.9 cm.111In-octreotide detected 16 of the 17 breast cancers (94%) while201Tl detected 13 of them (76%). Both111In-octreotide and201Tl missed one nonpalpable carcinoma showing only an isolated cluster of microcalcifications on mammography. The smallest tumour size detected by both agents 1.5×1.5 cm. Of the four benign lesions, only the breast abscess revealed both201Tl and111In-octreotide uptake.111In-octreotide scan also showed tracer uptake in five of the six patients with histologically proven axillary metastases, while four of these six patients showed201Tl uptake. The tumour/background (T/B) ratios of late111In-octreotide and201Tl images were 1.71±0.38 and 1.46±0.30 respectively (P=0.039). In this preliminary study,111In-octreotide yielded more favourable results than201Tl in the detection of breast carcinomas. However, the diagnostic efficacy of111In-octreotide imaging needs to be investigated in larger patient series. 相似文献
28.
Lutz Liefeldt Martin Buhl Britta Schweickert Elisabeth Engelmann Orhan Sezer Peter Laschinski Lothar Preuschof Hans-H Neumayer 《Nephrology, dialysis, transplantation》2002,17(10):1840-1842
29.
Effects of granulocyte colony-stimulating factor on bacterial translocation due to burn wound sepsis
Orhan Yalçin Gürsel Soybir Ferda Köksoy Hakki Köse Recep Öztürk Baki Çokne§eli 《Surgery today》1997,27(2):154-158
The presence of certain defects in both cellular and humoral immunity after thermal injury has been established. Likewise,
the translocation of enteric bacteria to the mesenteric lymph nodes and to distant organs has also been observed following
serious thermal injury. The effects of granulocyte colony-stimulating factor (G-CSF) on bacterial translocation, the small
bowel mucosa, and cecal bacterial content were investigated in a rat model of burn wound sepsis in which albino Wistar rats
were scalded over 30% of their bodies, after which the lesions were infected by 1×108 colony-forming units (cfu)Pseudomonas aeruginosa. The control group was treated with 5% dextrose solution subcutaneously starting 2 days preburn, while the treatment group
received 100μg/kg human G-CSF subcutaneously. On the 4th day post burn all animals were killed to examine the bowel and culture
of the mesenteric lymph nodes (MLN), livers, and spleens. No significant differences were observed between the groups regarding
the cecal bacterial content and small bowel; however, a difference was seen in the ratio of translocation in the MLN liver
and spleen and quantitative MLN cultures. Based on these findings, G-CSF was thus found to be significantly effective in reducing
bacterial translocation due to burn wound sepsis. 相似文献
30.
Bilge Türk Bilen Hidir Kilin? Nezih Alaybeyoglu Mehmet Celik Mustafa Iraz Nurzen Sezgin Ahmet Gültek 《Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi》2006,40(2):73-78
Oxygen-derived free radicals have been implicated in the pathogenesis of tissue injury after ischaemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active ingredient of honeybee propolis, has been identified as having potent antioxidant and anti-inflammatory properties. We evaluated the ability of CAPE applied intraperitoneally in reducing tissue injury after ischaemia-reperfusion. To investigate whether treatment with CAPE modifies the concentrations of the endogenous indices of oxidant stress, we examined its effects on a model of flap ischaemia-reperfusion injury in rats. CAPE (10 micromol/kg) was given through the peritoneum before reperfusion. CAPE given intraperitoneally had an inhibitory effect on tissue injury after ischaemia-reperfusion comparable to that of a control group. The anti-inflammatory and antioxidant properties of CAPE may contribute to its suppression of tissue injury. 相似文献