全文获取类型
收费全文 | 12182篇 |
免费 | 1308篇 |
国内免费 | 470篇 |
专业分类
耳鼻咽喉 | 128篇 |
儿科学 | 223篇 |
妇产科学 | 199篇 |
基础医学 | 1636篇 |
口腔科学 | 163篇 |
临床医学 | 1566篇 |
内科学 | 1764篇 |
皮肤病学 | 476篇 |
神经病学 | 602篇 |
特种医学 | 559篇 |
外国民族医学 | 11篇 |
外科学 | 1092篇 |
综合类 | 1241篇 |
现状与发展 | 1篇 |
一般理论 | 4篇 |
预防医学 | 778篇 |
眼科学 | 319篇 |
药学 | 1597篇 |
15篇 | |
中国医学 | 668篇 |
肿瘤学 | 918篇 |
出版年
2024年 | 42篇 |
2023年 | 211篇 |
2022年 | 525篇 |
2021年 | 672篇 |
2020年 | 479篇 |
2019年 | 491篇 |
2018年 | 491篇 |
2017年 | 436篇 |
2016年 | 504篇 |
2015年 | 718篇 |
2014年 | 847篇 |
2013年 | 778篇 |
2012年 | 1174篇 |
2011年 | 1067篇 |
2010年 | 616篇 |
2009年 | 527篇 |
2008年 | 665篇 |
2007年 | 608篇 |
2006年 | 481篇 |
2005年 | 476篇 |
2004年 | 347篇 |
2003年 | 327篇 |
2002年 | 260篇 |
2001年 | 149篇 |
2000年 | 148篇 |
1999年 | 180篇 |
1998年 | 99篇 |
1997年 | 98篇 |
1996年 | 65篇 |
1995年 | 74篇 |
1994年 | 44篇 |
1993年 | 34篇 |
1992年 | 55篇 |
1991年 | 43篇 |
1990年 | 32篇 |
1989年 | 27篇 |
1988年 | 26篇 |
1987年 | 29篇 |
1986年 | 14篇 |
1985年 | 16篇 |
1984年 | 5篇 |
1983年 | 10篇 |
1982年 | 6篇 |
1981年 | 4篇 |
1979年 | 8篇 |
1970年 | 7篇 |
1968年 | 3篇 |
1966年 | 6篇 |
1965年 | 3篇 |
1935年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
以液体稀释法比较了自制与进口十六烷基吡啶作用于4种口腔常见微生物的最低抑菌浓度和最低杀菌浓度的实验结果,经t检验证明两者间无显著差异,提示自制氯化十六烷基吡啶的药效质量可靠。并就控制接种菌量及杀菌机理等问题作了初步探讨。 相似文献
32.
本文用反复静脉注射小剂量牛血清白蛋白复制家兔慢性肾炎,用羊踯躅根治疗。同时,用该药对慢性肾炎病人进行疗效观察。阳性组兔肾小球呈现中至重度颗粒形免疫荧光,肾组织呈明显慢性硬化性肾小球肾炎改变。尿蛋白±~++。治疗组兔及病人治疗后病变及症状均明显减轻或消失。结果提示循环免疫复合物反复沉着可引起兔类似人类的慢性硬化性肾小球肾炎,羊踯躅根对病变有一定的控制和治疗作用,这可能与其抑制免疫发病机制有关。 相似文献
33.
红花注射液治疗冠心病心绞痛、心肌缺血临床观察 总被引:17,自引:0,他引:17
目的:观察红花注射液治疗冠心病心绞痛、心肌缺血的临床疗效。方法:选择126例冠心病心绞痛、心肌缺血的病例,分红花组及丹参组,疗程两周,详细记录治疗前后的临床表现、心电图、血糖、血脂、血液流变学检查的变化。结果:红花、丹参均可明显改善冠心病心肌缺血相应的临床症状和心电图改变,以红花较显著。红花还有降血糖、血脂作用,显著改善血液流变指标。结论:红花注射液是治疗冠心病心绞痛、心肌缺血的理想药物。 相似文献
34.
3-Monochloro-1,2-propanediol (MCPD) is a well-known by-product of acid-hydrolyzed soy sauce during its manufacturing process. MCPD has been reported genotoxic in vitro, and reproductive toxicity and carcinogenicity in rats. To evaluate the immunomodulatory effect of MCPD on murine splenocyte and macrophage in vitro, we investigated splenocyte blastogenesis by concanavalin A (Con A), anti-CD3, and lipopolyssacharide (LPS), the production of cytokines from splenocyte, and the activity of mouse peritoneal macrophages. There was a significant decrease in lymphocyte blastogenesis to Con A or anti-CD3 at subtoxic dose of MCPD. A significant decrease in splenocyte blastogenesis to LPS was also observed. The production level of interferon (IFN)-gamma on splenocyte culture with Con A was significantly reduced at the higher concentration than 1.0mM of MCPD. The levels of interleukin (IL)-4 and IL-10 were also decreased at high concentrations of MCPD. There was a significant decrease in production of nitric oxide (NO) by peritoneal macrophages treated with MCPD. MCPD also inhibits tumor necrosis factor (TNF)-alpha production of stimulated macrophages. These results indicate that MCPD might be able to reduce the functionality of lymphocytes and peritoneal macrophages in vitro. 相似文献
35.
Mi Sook Gwak Kwang-Woong Lee Shi Yeon Kim Jihyun Lee Jae Won Joh Sung Joo Kim Hwan Hyo Lee Jean Wan Park Gaab Soo Kim Suk-Koo Lee 《Liver transplantation》2005,11(3):331-335
During liver transplantation for hepatocellular carcinoma (HCC) patients, HCC could theoretically be introduced into the systemic circulation when salvaged blood is used with an autotransfusion device. Several reports have shown that some types of leukocyte depletion filters (LDFs) could completely reduce the risk for reintroducing some types of tumor cells. In this study, we tested the ability of the LDF (RCEZ1T, Pall Biomedical Co, NY, USA) to reduce the risk for reintroducing HCC cells in vitro by using a very sensitive detection method. We divided the test group into 6 groups: group I was 10 cells, group II was 20 cells, group III was 2 x 10(3) cells, group IV was 2 x 10(5) cells, group V was 2 x 10(6) cells, and group VI was 2 x 10(7) cells. The counted cells in 200 mL saline were passed through the RCEZ1T using the force of gravity. To identify the presence of cells, the pellet was resuspended, and polymerase chain reaction (PCR) was performed. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a housekeeping gene, was used as a primer. In groups I and II, the HCC cells were completely filtered in all experiments. However, in groups III, IV, and V, the HCC cells were not completely filtered in a few of the repeated experiments, with the unfiltered rate of tumor cells being between 8% and 20%. In group VI, the HCC cells were not completely filtered in all the repeated experiments. In conclusion, the RCEZ1T filter markedly reduced the risk for reintroduction of HCC cells. However, at high HCC cell load the filter cannot completely remove all the tumor cells. Further studies are required to assess the impact in clinical settings. 相似文献
36.
Bum Soon Choi Mi Jung Shin Suk Joon Shin Young Soo Kim Yeong Jin Choi Yong-Soo Kim In Sung Moon Suk Young Kim Yong Bok Koh Byung Kee Bang Chul Woo Yang 《American journal of transplantation》2005,5(6):1354-1360
We report here our 10-year experience of a biopsy performed at day 14 after transplantation in 304 patients with stable graft function. The factors that may have influenced subclinical rejection were analyzed according to histology. The incidence of subclinical rejection was 13.2%. Addition of mycophenolate mofetile (MMF) as a primary immunosuppressant significantly decreased the incidence of subclinical rejection compared with patients without such treatment (odds ratio, 0.23; p < 0.05). On the other hand, HLA-DR antigen mismatch (odds ratio, 2.39) and unrelated donor (odds ratio, 2.10) were also significantly associated with decreased subclinical rejection (p < 0.05). The incidence of acute rejection in patients with normal findings was lower than in those with borderline changes or subclinical rejection (0.23 +/- 0.05 vs. 0.48 +/- 0.07 and 0.60 +/- 0.11, respectively; p < 0.05). The graft survival rates in patients with subclinical rejection were lower than in patients with normal or borderline changes at 1 (88.4% vs. 97.9% and 99.1%; p < 0.05), 5 (77.8% vs. 96.2% and 95.9%; p < 0.05) and 10 (62.3% vs. 96.2% and 93.7%; p < 0.05) years. Thus, a protocol biopsy performed on day 14 after transplantation is useful for predicting graft survival. Triple therapy including MMF, related donor and HLA-DR antigen match are important factors for reducing subclinical rejection in living-donor renal transplantation. 相似文献
37.
Mié Matsui Hiromi Yuuki Kanade Kato Ai Takeuchi Shimako Nishiyama Warren B Bilker Masayoshi Kurachi 《Journal of the International Neuropsychological Society》2007,13(4):672-682
This study compares neuropsychological functioning in a Japanese schizophrenia spectrum disorder group and a group of healthy Japanese volunteers. Participants were 37 patients diagnosed with schizophrenia, 28 schizotypal patients, and 99 psychiatrically-normal volunteers. A wide range of cognitive measures were examined. All participants completed a Japanese version of a neuropsychological battery assessing executive function, working memory, processing speed, language, verbal memory, and spatial organization. Comparisons of neuropsychological function demonstrated similarities and differences between patients diagnosed with schizotypal disorder and those diagnosed with schizophrenia. Impairments in verbal memory, language, and processing speed were common to both patient groups and may represent a vulnerability to schizophrenia. Impairments in aspects of working memory, spatial organization and executive function were preferentially observed in schizophrenia and may be features of the overt manifestation of psychosis. Possible differences in the contributions of prefrontal and temporo-limbic structures provide direction for further studies. 相似文献
38.
分别用聚二醇,1-2丙醇,无水乙醇与水组成不同比例的二元溶剂系统,测定了弱极性药物SMZ及TMP在上述各系统中的溶解度。从而导出药物溶解度与二混合溶剂体积分类间的半实验方程。 相似文献
39.
采用鼠抗PCNA单克隆抗体,ABC法,对11例正常口腔粘膜及29例口腔鳞癌进行了染色。结果表明:正常粘膜仅在基底层中有少量的PCNA阳性细胞,其阳性分级为1级。而鳞癌阳性分级主要是3~4级,随着组织学分级的升高,PCNA阳性表达率也相应增高。经统计学分析,正常组织与鳞癌之间及鳞癌各级均有非常显著差异(P<001)。提示:PCNA的表达与口腔鳞癌组织学分级有关。 相似文献
40.
实验性视网膜光化学损伤中的蛋白激酶C 总被引:2,自引:0,他引:2
目的:研究实验性视网膜光化学损伤中蛋白激酶C(protein kinase C,PKC)活性的改变;探索地塞米松(dexamethasone,DXM)对视网膜中PKC活性的影响。
方法;48只SD大鼠分为对照组和DXM组,后者于光照前3天开始,连续5天腹膜腔注射DXM 1mg/(kg·d)。经(1 900±106.9)Ix的绿色荧光灯(λ=510nm~560nm)连续照射24小时后的6小时和1、3、7、14天,进行视网膜PKC活性检测。
结果:光化学损伤后视网膜中的PKC活性在短暂的上升后即出现持续性的下降;DXM对PKC的活性改变无明显作用。
结论:光化学损伤中的视网膜功能障碍可能与PKC活性的持续降低有关。
(中华眼底病杂志,1997,13:78-80) 相似文献