全文获取类型
收费全文 | 18705篇 |
免费 | 1177篇 |
国内免费 | 90篇 |
专业分类
耳鼻咽喉 | 174篇 |
儿科学 | 256篇 |
妇产科学 | 204篇 |
基础医学 | 2574篇 |
口腔科学 | 652篇 |
临床医学 | 1770篇 |
内科学 | 3933篇 |
皮肤病学 | 517篇 |
神经病学 | 1993篇 |
特种医学 | 1218篇 |
外科学 | 3035篇 |
综合类 | 90篇 |
一般理论 | 6篇 |
预防医学 | 881篇 |
眼科学 | 381篇 |
药学 | 988篇 |
中国医学 | 51篇 |
肿瘤学 | 1249篇 |
出版年
2024年 | 11篇 |
2023年 | 128篇 |
2022年 | 247篇 |
2021年 | 533篇 |
2020年 | 355篇 |
2019年 | 423篇 |
2018年 | 537篇 |
2017年 | 436篇 |
2016年 | 587篇 |
2015年 | 661篇 |
2014年 | 804篇 |
2013年 | 1010篇 |
2012年 | 1579篇 |
2011年 | 1482篇 |
2010年 | 922篇 |
2009年 | 800篇 |
2008年 | 1316篇 |
2007年 | 1409篇 |
2006年 | 1304篇 |
2005年 | 1218篇 |
2004年 | 1093篇 |
2003年 | 991篇 |
2002年 | 874篇 |
2001年 | 171篇 |
2000年 | 107篇 |
1999年 | 164篇 |
1998年 | 157篇 |
1997年 | 135篇 |
1996年 | 80篇 |
1995年 | 52篇 |
1994年 | 41篇 |
1993年 | 46篇 |
1992年 | 43篇 |
1991年 | 22篇 |
1990年 | 20篇 |
1989年 | 20篇 |
1988年 | 24篇 |
1987年 | 14篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 11篇 |
1983年 | 6篇 |
1982年 | 15篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1977年 | 7篇 |
1976年 | 5篇 |
1974年 | 7篇 |
1973年 | 11篇 |
1970年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 328 毫秒
991.
992.
Wöhrle J Grebe OC Nusser T Al-Khayer E Schaible S Kochs M Hombach V Höher M 《Circulation》2003,107(14):1840-1843
993.
994.
995.
Kühl U Pauschinger M Schwimmbeck PL Seeberg B Lober C Noutsias M Poller W Schultheiss HP 《Circulation》2003,107(22):2793-2798
996.
997.
998.
999.
Sorting of certain membrane proteins requires a mechanism involving rafts, protein-lipid complexes enriched in glycosphingolipids and cholesterol. These microdomains remain at the plasma membrane of different cell types and play a role in signal transduction. Although recent reports have begun to describe molecules associated with rafts, their protein composition remains largely unknown, especially in neuronal cells. To address this question, we have purified detergent-insoluble raft fractions (DRMs) from primary cultures of hippocampal neurons. Bidimensional gel analysis and pharmacological raft lipid manipulation allowed the identification of neuronal raft proteins and their characterisation by MALDI-TOF analysis. Enolases were found among the proteins identified and functional studies demonstrate their participation in plasminogen binding. We also show the specific enrichment in rafts of several other plasminogen binding molecules and the exclusive activation of plasminogen to the protease plasmin in these microdomains. These observations suggest that neuronal rafts may play, in addition to intracellular signaling, a role in extracellular/membrane protein proteolysis. 相似文献
1000.
OBJECTIVE: To study gender differences of coping with illness strategies in tension-type headaches. METHOD: We enrolled 89 subjects (50 women, 39 men) suffering from episodic (n = 37) and chronic (n = 52) tension-type headaches (TTH). Patients were required to answer a Freiburg Questionnaire of Coping with Illness (FQCI), a Von Zerssen Depression Scale (D-S), quality-of-life questionnaires, and a headache home diary (over 4 weeks). In addition, pressure pain thresholds (temporal muscles) and Total Tenderness Scores were obtained. RESULTS: While pain intensity, frequency and quality-of-life parameters were basically the same for female and male EPISODIC TTH sufferers, women scored significantly higher on the F3 subscale (distracting and encouraging) of the FQCI and tended to score higher on the F1 subscale (depressive). Among CHRONIC TTH patients, women reported the pain to be more intense (VAS), were more depressed (D-S), and scored lower on several quality-of-life scores. Female chronic TTH sufferers scored significantly lower on the F2 subscale (active coping) and tended to score higher on F5 (denying). CONCLUSIONS: We conclude that pessimistic coping with illness strategies are more frequent in female episodic and chronic TTH sufferers. We would like to recommend special psychologic intervention in particular to female chronic TTH sufferers which would offer counseling in developing active coping skills. 相似文献