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991.
992.
红花对大鼠心脏功能的影响 总被引:12,自引:1,他引:12
红花50、500、200mg生药/kgiv,均能使大鼠心率显著减慢(p<0.05),左室内压(LVP)、左室内压最大变化速率(±dp/dtmax)、等容收缩和零负荷情况下心肌收缩成分缩短速度(dp/dt/CPIP、Vmax)呈现不同程度的抑制效应。红花50、250mg生药/L灌流大鼠离体心脏能使冠脉流量(CF)明显增加(p<0.05),结果提示红花有益于心脏缺血疾病的防治。 相似文献
993.
994.
Elizabeth A. Platz Maria Elena Martinez Francine Grodstein Charles S. Fuchs Graham A. Colditz Meir J. Stampfer Edward Giovannucci 《Cancer causes & control : CCC》1997,8(6):894-903
Evidence for an effect of reproductive factors on colorectal carcinogenesis is inconsistent and little is known about their
role in development of precursor adenomatous polyps. We evaluated the relation between reproductive factors and distal colorectal
adenomas (n = 982) during14 years of follow up of 26,983 participants in the Nurses' Health Study(United States). The women
were free of diagnosed cancer or polyps in 1980,underwent endoscopy 1980-94, and had reported on their parity, oral contraceptive
(OC) use, and ages at menarche, first term-pregnancy, and menopause. We calculated relative risks (RR) and 95 percent confidence
intervals (CI) using multiple logistic regression. Women with higher parity had an increased risk of adenomas of the distal
colorectum (P trend = 0.004;6+ cf 0 parity: RR = 1.3, CI = 0.9-1.8) or distal colon (P trend = 0.002, RR= 1.7, CI = 1.2-2.6).
This association was significantly stronger among women with a family history of colorectal cancer ( P interaction = 0.03);
comparing6+ term-pregnancies with nulliparity, among those with a family history, the RR for distal colon adenoma was 3.2
(CI = 1.4-7.2), while among those without a family history, the RR was 1.3 (CI = 0.8-2.2). We observed no association for
distal colorectal adenoma and age at menarche, age at first term-pregnancy, ever use of OCs, or menopausal status. Further
work is needed to clarify the relation of parity with colon adenoma risk.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
995.
Jianguo Ma Marc Maliepaard Herman J. Kolker Jaap Verweij Jan H. M. Schellens 《Cancer chemotherapy and pharmacology》1997,41(3):186-192
The parental IGROV-1 human ovarian adenocarcinoma cell line was intermittently exposed to increasing concentrations of cisplatin
to obtain resistant sublines. A stable resistant subline with a resistance factor of 8.4 had been developed after 9 months
and 28 passages, which was denoted IGROVCDDP. A high correlation coefficient of 0.97 was found between the log cell survival and the DNA-adduct peak level during the
process of resistance development. IGROVCDDP was strongly cross-resistant to carboplatin and doxorubicin and moderately cross-resistant to etoposide, docetaxel, and topotecan.
Only minor resistance against 5-fluorouracil was observed, whereas IGROVCDDP was not cross-resistant to methotrexate. Intracellular accumulation of cisplatin was 65% lower in IGROVCDDP as compared with parental IGROV-1 at 37 °C under normal conditions. Coincubation of cisplatin with the Na+/K+-ATPase inhibitor ouabain resulted in a more pronounced decrease in platinum accumulation in IGROV-1 (44% decrease) than in
IGROVCDDP (26% decrease). Under energy-depleting conditions the accumulation of cisplatin in the parental cell line was approximately
60% lower than that observed under normal (energy [i.e., ATP] rich) culture conditions. In contrast, the accumulation in IGROVCDDP was not affected by ATP-depletion. There appeared to be no significant difference between the intracellular accumulation
of platinum in the resistant and sensitive cells under conditions of energy deprivation or when the uptake was studied at
0 °C. In conclusion, abrogation of energy-dependent accumulation in IGROVCDDP seems to be a major mechanism of resistance to cisplatin in this cell line.
Received: 21 January 1997 / Accepted: 22 July 1997 相似文献
996.
环枢关节紊乱症的临床研究 总被引:5,自引:1,他引:5
马东升 《中国中医骨伤科杂志》1997,5(5):10-13
环枢关节紊乱症,从发病机理到临床表现,乃是颈椎病中较复杂的疑难顽症。用常规诊治方法,疗效不佳。本研究提出新的诊断依据与治疗方法,对320例病者随机分为治疗组166例(采用改进的诊治方法),对照组154例(用常规诊治方法)对照进行疗效观察。结果显示:治疗组治愈率与总有效率及康复率均高于对照组。有非常显著差异,P<0.01。而疗程较对照组短。环枢关节紊乱症的临床研究有利于颈椎病诊治水平的提高,运用于临床,疗效好,效益高,具有推广应用价值。 相似文献
997.
六味地黄汤及拆方对大鼠巨噬细胞ADCC活性的影响 总被引:7,自引:1,他引:7
六味地黄汤能明显促进正常大鼠MφADCC活性,并能有效防止阴虚大鼠MφADCC活性的下降。“三补”方与此相仿,“三泻”方作用不明显,但二者有一定协同作用。 相似文献
998.
Segmental bone defects in long bones often pose achallenge tO their sMcal ~nt, and the vasculallzedperiosted po used either alone or in combination withother ~ materials has been Preferred as a uSeals solution to this Problems"'l. HOwever, the use Of vascularized graft has to resort to ndcrosuopcal tecboqUes, Whichmakes it difficult tO populallze this OPe~ in the graSsests level intitutions. We Pimeeded with combined useOf free Periosteum and new reconshtuted bine xenograft(NRBX) in re… 相似文献
999.
Ⅱ型糖尿病和高血压患者血液动力学改变的相关因素分析 总被引:5,自引:3,他引:2
目的:探讨糖病和高血压血管并发症的发生机理。方法:分别测定高血压(HT)组、Ⅱ型糖尿病(NID-DM)组及Ⅱ型糖尿病合并高血压组和对照组的胰岛素水平、血脂、心脏彩超和血液流变学指标。结果:3个试验组的周围总阻(TPR)、甘油三酯(TG)和胰岛素面积(InsS)均明显增高,其中HT组和NIDDM合并HT组的左室收缩期峰值室壁应力(PSS)也明显增高:NIDDM合并HT组InsS明显高于其他三组,三试 相似文献
1000.
Prominent neuronal differentiation and MYCN amplification occur only in a small percentage of medulloblastomas (primitive neuroectodermal tumor of the cerebellum). In this article, we describe two medulloblastomas that showed a striking degree of neuronal differentiation with islands of mature neurons associated with abundant neuropil. In these differentiated foci, there were no mitoses or atypia, and the histology was reminiscent of a malformative or hamartomatous lesion. Both tumors were assessed for MYCN amplification by the novel technique of differential polymerase chain reaction (PCR) and fluorescent in situ hybridization (FISH). In case 1, MYCN amplification was in the 10 - fold range determined by differential PCR, while in case 2 the level of amplification was marked, with 20 - 30 copies compared with diploid controls. FISH analysis also confirmed the presence of MYCN amplification in both tumors. These two cases are of great interest, especially as they show MYCN amplification in medulloblastomas with marked degree of neuronal differentiation. Furthermore, in both cases, there was evidence of a slower and more indolent clinical course, suggesting a more favorable outcome in medulloblastoma with this degree of neuronal differentiation. 相似文献