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991.
本实验采用低叶酸培养条件,对一个鼻咽癌高发家族成员和配对的正常人作了染色体畸变研究。结果:家族血缘亲属组和对照组染色体畸变率(CAR)分别为11.01%和5.06%,两者比较有高度显著性差异(P<0.001);配偶组CAR为4.6%。与对照组比较无显著性差异(P>0.25);家族中一非癌成员发现t(7;14)(P22;q22)2次,与文献报告在2例鼻咽癌患者外周血发现的染色体易位完全相同。文章讨论了染色体畸变与鼻咽癌遗传易感性的关系,认为特殊的培养条件可使家族成员CAR与正常人之间的差距加大。 相似文献
992.
We previously reported the discovery of 14 channels in the human body, which possessed the biophysical property of high emission of light. In this study we found the same property on the Ren and Du channels in healthy rats. Additionally, we discovered that the luminance of the related channels in rat models with different "syndromes" varied greatly. For instance, a markedly low luminance appeared on the Du channel in animals with experimental syndrome of Yang deficiency induced by hydrocortisone; while in animals with experimental syndrome of blood deficiency caused by bleeding, an apparently low luminance occurred on the Ren channel. The intensity of the emitted light on Du and Ren channels increased after acupuncture treatment, but not significantly. This phenomenon conforms to the theory in traditional Chinese medicine that the Du channel is the "sea of Yang channels", while the Ren channel is the "sea of Yin channels". 相似文献
993.
Lai ST Cheng KK Yu TJ Kuo SM Weng Z Chang Y Lee PS Cheng PC 《Journal of clinical laser medicine & surgery》1991,9(6):485-491
From March to July 1989, nine patients at risk for peripheral artery disease underwent intraoperative Nd:YAG laser angioplasty using angioscopy at the Veterans General Hospital (Taipei, Taiwan, Republic of China). Following the laser angioplasty, balloon dilatation was performed in all cases. Eight men and one woman at an average age of 68 were included in the study (range: 58 to 78 years old). Ischemic symptoms included five patients with disabling claudication, four with pain at rest and one with gangrene on the toes. Eight of the nine patients had complete occlusions ranging from 2 to 19 cm in length. Two patients had high degree multiple segmental stenosis of the superficial femoral artery from 1 to 2 cm in length. Initial clinical success (indicated by relief of symptoms and increase in Doppler ankle pressure and index) and improvement in the angiographic luminal diameter was noted in 9 of 10 occluded vessels (90%) that underwent Nd:YAG laser treatment which was delivered at 10 to 12 watts through laser probes. Prelaser intraluminal diameter increased from 0.05 +/- 0.07 to 0.53 +/- 0.07 mm, Doppler ankle pressure index rose from 0.51 +/- 0.12 to 0.81 +/- 0.12, Doppler ankle pressure increased from 62.44 +/- 16.10 to 104 +/- 21.21 mmHg and the amplitude of pulse volume recorder at ankle level rose from 5.77 +/- 2.80 to 12.11 +/- 2.77 mm as compared with prelaser therapy (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
994.
J. Graham Sharp James W. Osborne Ph.D. H. F. Cheng K. L. Coop George R. Zimmerman 《European journal of nuclear medicine and molecular imaging》1982,7(1):28-34
Radioiodinated antitumor (Ab-gamma globulins), non-tumor-specific Ab, and R131ISA were used for imaging radiation-induced intestinal tumors in rats. Each agent detected tumors larger than 2 g, but labeled Ab were most efficient in detecting smaller tumors. Tissue distribution studies showed that while purified Ab localized specifically in tumors, unpurified Ab concentrated in the tumor by a mechanism not considered immunological. Localization was variable and the concentration of antitumor Ab reached useful levels only in a small number of cases. The use of high specific activity purified Ab unexpectedly decreased the concentrations of label observed in the tumors when compared with the use of the same activity of low specific activity purified Ab. These results indicated the presence of circulating tumor antigens which were capable of binding the injected Ab. Subsequently, these findings have been substantiated. Thus the animal-to-animal variability could be explained on the basis of differing degrees of interaction of injected Ab with circulating tumor antigens. The usefulness of labeled purified or monospecific antitumor antibodies for tumor imaging and therapy would thus be influenced by the extent of such interactions.This work was presented in part at the Twentieth Annual Meeting of the Radiation Research Society, Portland, Oregon, May, 1972. 相似文献
995.
A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, active compounds of this series contain either an "isothioureido" [N-C(S-)=N-] or an "isothiosemicarbazono" [N-C(S-)=N-N=] structural unit. 相似文献
996.
997.
To devise a new classification of vascular variations in second toe transfer we analyzed the anatomic details of the first dorsal metatarsal artery in 304 cases of second toe transplantation and the venous structure in 200 cases. According to location, the arterial vascularity was classified as superficial (18% of cases), intramuscular (54%), inframuscular (23%), and absent (5%). According to diameter, it was classified into large (16%), medium (64%), and small (20%). Based on branching pattern, the artery was classified into ramifying type (88%), main trunk (4%), and fine branch type (8%). The venous drainage of the second toe was categorized as greater saphenous vein main trunk type, greater saphenous vein fine branch type, dorsal digital vein main trunk type, and dorsal digital vein fine branch type. Variations of the first dorsal metatarsal artery are common. Classification should be done according to its location, diameter, and branching pattern at the toe web. Regardless of location, big vessels entering the second toe are the most important attribute for successful outcome. 相似文献
998.
目的 观察路路通治疗糖尿病高脂及高粘血症的临床效果。方法 42例糖尿病合并高脂及高粘血症患者随机分组对照观察 ,路路通治疗组 2 2例给予路路通注射液 1 0g溶于低分子右旋糖酐注射液 5 0 0ml中静点 ,每日 1次 ,共 4周 ;对照组 2 0例降血糖等基本治疗与路路通组相同 ,另外只给予低分子右旋糖酐注射液 5 0 0ml静点 ,每日 1次 ,共 4周。结果 路路通组降血脂的总有效率为 80 % ,而对照组则无明显改善 ,差异显著 ,P <0 0 5。对高粘血症的有效率也显著高于对照组 ,P <0 0 5。结论 路路通对糖尿病高脂及高粘血症有良好疗效 相似文献
999.
1000.
HPLC测定新疆贯叶金丝桃中金丝桃素的含量 总被引:3,自引:0,他引:3
目的 建立测定新疆贯叶金丝桃中金丝桃素含量的测定方法。方法 采用HPLC法 ,KromasilODS - 1色谱柱 (4 .6mm× 2 0 0mm ,5 μm) ,流动相为甲醇 -pH 6 .5磷酸盐缓冲液 (90∶10 ) ,流速 1ml·min- 1 ,柱温 4 0℃ ,检测波长 5 88nm。结果 金丝桃素和其他组分可达基线分离 ,线性范围为 0 .0 16 5~ 0 .0 82 5 μg(r=0 .9999) ,平均回收率为 10 1.1% ,RSD =3.7% (n =9)。 结论 本法操作简便快速 ,灵敏准确。新疆贯叶金丝桃药材中金丝桃素的含量略高于美国药典的要求。 相似文献