全文获取类型
收费全文 | 409篇 |
免费 | 26篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 31篇 |
妇产科学 | 7篇 |
基础医学 | 35篇 |
口腔科学 | 11篇 |
临床医学 | 52篇 |
内科学 | 73篇 |
皮肤病学 | 11篇 |
神经病学 | 32篇 |
特种医学 | 65篇 |
外科学 | 40篇 |
综合类 | 16篇 |
预防医学 | 20篇 |
眼科学 | 9篇 |
药学 | 17篇 |
1篇 | |
肿瘤学 | 14篇 |
出版年
2022年 | 3篇 |
2021年 | 4篇 |
2020年 | 8篇 |
2019年 | 4篇 |
2018年 | 7篇 |
2017年 | 4篇 |
2016年 | 13篇 |
2015年 | 15篇 |
2014年 | 8篇 |
2013年 | 13篇 |
2012年 | 22篇 |
2011年 | 12篇 |
2010年 | 14篇 |
2009年 | 19篇 |
2008年 | 24篇 |
2007年 | 20篇 |
2006年 | 19篇 |
2005年 | 18篇 |
2004年 | 16篇 |
2003年 | 17篇 |
2002年 | 18篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 4篇 |
1998年 | 8篇 |
1997年 | 21篇 |
1996年 | 8篇 |
1995年 | 10篇 |
1994年 | 11篇 |
1993年 | 7篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1989年 | 6篇 |
1988年 | 11篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 6篇 |
1977年 | 8篇 |
1976年 | 4篇 |
1974年 | 2篇 |
1970年 | 1篇 |
1966年 | 1篇 |
1964年 | 2篇 |
1963年 | 1篇 |
1943年 | 1篇 |
排序方式: 共有435条查询结果,搜索用时 31 毫秒
91.
Kocer A Karakaya O Barutcu I Batukan Esen O Kargin R Mayda Domac F 《Progress in neuro-psychopharmacology & biological psychiatry》2006,30(4):718-723
Cardiovascular disorders such as decreased heart rate variability, orthostatic hypotension, and arrhythmias have been frequently observed in Parkinson's disease (PD) patients. In this study, authors measured P wave duration and dispersion in PD patients and controls. Twenty-three consecutive patients with idiopathic PD and sex-age matched 23 control subjects were included to the study. A 12-lead surface ECG was obtained from each participant. Maximum-minimum P wave duration and P wave dispersion (PWD) were measured in both groups. Maximum P wave duration was found to be higher in PD patients than controls (117+/-12 vs. 105+/-9 ms p=0.001). Minimum P wave duration was similar in PD patients and controls (64+/-11 vs. 63+/-11 ms p=0.7). PWD in PD patients was also found to be higher than those of controls (53+/-11 vs. 43+/-10 ms p=0.0001). P wave duration and PWD did not significantly differ between PD patients taking anti-parkinsonian agents from those who were not (119+/-13 vs. 116+/-13 ms p=0.4 and 55+/-11 vs. 52+/-11 ms p=0.5, respectively). Moreover, when the PD patients taking anti-parkinsonian agents were excluded from the study, PD patients had still higher P wave duration and PWD compared to controls (119+/-11 vs. 105+/-9 ms p=0.004, 52+/-10 vs. 43+/-10 ms p=0.009, respectively). In conclusion, we found that P wave duration and PWD were greater in PD patients compared to control subjects. 相似文献
92.
93.
Gazioglu N Ulu MO Ozlen F Albayram S Islak C Kocer N Oz B Tanriover N Yetkin DO Gundogdu S Acbay O Kadioglu P 《Clinical neurology and neurosurgery》2008,110(4):333-338
OBJECTIVE: The aim of this study was to determine the accuracy of bilateral cavernous sinus sampling (CSS) in preoperative tumor lateralization (right/left) within the pituitary in patients with Cushing's disease (CD). PATIENTS AND METHODS: The study consisted of 26 consecutive patients who had undergone CSS followed by transsphenoidal surgery (TS) for CD between 2000 and 2006 at our institution. The magnetic resonance imaging (MRI) of the selected patients either revealed a normal pituitary or a lesion 相似文献
94.
95.
Kathleen J. Sawin DNS RN CPNP FAAN Melissa H. Bellin PhD MSW LCSW Gayle Roux PhD RN NP‐C Constance F. Buran DNS RN NE‐BC Timothy J. Brei MD FAAP 《Rehabilitation nursing》2009,34(1):26-38
It is essential for youth with chronic health conditions like spina bifida (SB) to develop self‐management skills to combat vulnerability, achieve self‐sufficiency, and transition to adulthood. The purpose of this qualitative study was to describe the experience of self‐management in 31 adolescent women with SB. Three themes emerged from this study: (1) opportunities to engage in self‐management activities—knowledge, skills, and aspirations; (2) dance of individuation—parental impact on self‐management; and (3) advocacy within self‐management—confronting discrimination and stigma. The findings indicate that assessment and interventions to enhance self‐management in adolescent women with SB are critical for supporting the range of condition‐related and life skills needed for a transition to adulthood and independent living. 相似文献
96.
97.
Belgin Kocer Tugba Unal Bijen Nazliel Zeynep Biyikli Zulal Yesilbudak Sirel Karakas Ceyla Irkec 《Neurological sciences》2008,29(6):435-444
Objective This study investigated the presence of sub-clinical cognitive dysfunction in patients with clinically isolated syndrome (CIS)
and the abnormalities of cognitive event-related potentials (ERPs).
Methods Subclinical cognitive dysfunction was assessed in 20 patients with CIS and in 20 healthy controls.
Results Patients had impairments in verbal learning and long-term memory, evaluating attention, executive function and visuospatial
skills, in decreasing order of frequency. SDLT and SIT were the most, and COWAT and BNT were the least affected tests. The
N200 and P200 latencies were prolonged, and N100, N200 and P200 amplitudes were reduced in the patients relative to the controls,
from the Fz, Cz and Pz electrode positions (p<0.05).
Conclusion Detailed cognitive testing is valuable in determining subclinical cognitive dysfunction in CIS patients. ERP abnormalities
as well as abnormalities in detailed cognitivetesting in patients with CIS are helpful in the diagnosis of sub-clinical cognitive
dysfunction. 相似文献
98.
SAVOLAINEN KOSONEN LINTU VIANDER PÈNE KALIMO TERHO & BOUSQUET 《Clinical and experimental allergy》1999,29(6):824-831
BACKGROUND: The cytokine observed most often in atopic dermatitis (AD) is IL-4, but a role for IL-5 and IFN-gamma in the late and delayed phase reactions has been suggested. In AD with head, neck and shoulder distribution, hypersensitivity to saprophytic yeasts is an important pathogenetic factor. The yeast allergens include both the mannan polysaccharides and the proteins. Mannans are major cross-reacting allergens likely to be involved in the pathogenesis of AD. OBJECTIVE: To characterize the humoral, lymphoproliferative and cytokine (IL-2, 4, 5 and IFN-gamma) responses of peripheral blood mononuclear cells (PBMCs) induced by Candida albicans mannan and protein antigens in AD. METHODS: Fifteen AD patients and seven healthy controls were included. Ficoll-isolated PBMCs were stimulated by PHA and laboratory-generated mannan and protein extracts of C. albicans. Lymphocyte proliferation was measured and cytokine production was studied by ELISA. The antigen-specific IgG and IgE antibodies were analysed by ELISA and nitrocellulose RAST. RESULTS: In AD mannan (P < 0.005) and protein (P < 0.002), specific IgE levels were higher than in healthy controls. Both mannan and protein-specific lymphoproliferations (both: P < 0.02) were higher in AD than in healthy controls. Mannan, but not protein, induced long lasting IL-2 and IL-4 productions from 24 h lasting up to 66-96 h and IL-5 and IFN-gamma productions with elevated levels at 66 and 96 h. The mannan-induced IL-2 (P = 0.015) and IFN-gamma (P < 0.005) were increased in AD as compared with healthy controls. Significant correlations were seen between the protein-induced proliferation responses and both serum total IgE (r = 0.59, P < 0.01) and protein-specific IgE (r = 0.65, P < 0.005). The mannan-induced IL-2 responses correlated with the specific IgE (r = 0.62, P < 0.01) and proliferation (r = 0.51, P < 0.02) and S-IgE level (r = 0.71, P < 0. 002). Mannan-induced IL-4 and IFN-gamma productions also correlated (r = 0.43, P < 0.05). CONCLUSIONS: C. albicans mannan induced elevated IL-2 and IFN-gamma responses in AD patients. The correlations of the cytokine responses with mannan-induced IgE and proliferation responses suggest that C. albicans mannan induced TH1 type cytokine responses are involved in AD. 相似文献
99.
100.