全文获取类型
收费全文 | 7196篇 |
免费 | 339篇 |
国内免费 | 74篇 |
专业分类
耳鼻咽喉 | 52篇 |
儿科学 | 222篇 |
妇产科学 | 120篇 |
基础医学 | 817篇 |
口腔科学 | 193篇 |
临床医学 | 419篇 |
内科学 | 2160篇 |
皮肤病学 | 76篇 |
神经病学 | 547篇 |
特种医学 | 316篇 |
外科学 | 1229篇 |
综合类 | 17篇 |
预防医学 | 102篇 |
眼科学 | 86篇 |
药学 | 354篇 |
中国医学 | 17篇 |
肿瘤学 | 882篇 |
出版年
2023年 | 51篇 |
2022年 | 82篇 |
2021年 | 190篇 |
2020年 | 100篇 |
2019年 | 165篇 |
2018年 | 184篇 |
2017年 | 166篇 |
2016年 | 209篇 |
2015年 | 180篇 |
2014年 | 277篇 |
2013年 | 298篇 |
2012年 | 471篇 |
2011年 | 534篇 |
2010年 | 339篇 |
2009年 | 275篇 |
2008年 | 437篇 |
2007年 | 453篇 |
2006年 | 467篇 |
2005年 | 511篇 |
2004年 | 497篇 |
2003年 | 430篇 |
2002年 | 422篇 |
2001年 | 66篇 |
2000年 | 59篇 |
1999年 | 74篇 |
1998年 | 85篇 |
1997年 | 64篇 |
1996年 | 57篇 |
1995年 | 50篇 |
1994年 | 45篇 |
1993年 | 39篇 |
1992年 | 25篇 |
1991年 | 30篇 |
1990年 | 28篇 |
1989年 | 37篇 |
1988年 | 26篇 |
1987年 | 20篇 |
1986年 | 10篇 |
1985年 | 10篇 |
1984年 | 9篇 |
1983年 | 13篇 |
1982年 | 29篇 |
1981年 | 17篇 |
1980年 | 11篇 |
1979年 | 9篇 |
1978年 | 10篇 |
1977年 | 14篇 |
1975年 | 4篇 |
1972年 | 5篇 |
1967年 | 4篇 |
排序方式: 共有7609条查询结果,搜索用时 453 毫秒
41.
An Epstein-Barr virus-producer line Akata: Establishment of the cell line and analysis of viral DNA 总被引:10,自引:0,他引:10
Kenzo Takada Kenichi Horinouchi Yasushi Ono Takao Aya Toyoro Osato Motoo Takahashi Shinichi Hayasaka 《Virus genes》1991,5(2):147-156
An Epstein-Barr virus (EBV)-producer line, designated Akata, was established from a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type chromosome translocation, t(8q-; 14q+), and was derived from the tumor cell. Akata cells produced a large quantity of transforming virus upon treatment of cells with anti-immunoglobulin antibodies (Takada, 1984). Southern blot analysis of viral DNA indicated that the Akata EBV is nondefective and more representative of wild-type viruses. Akata cells should be useful as a source of EBV. 相似文献
42.
The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants 总被引:2,自引:0,他引:2
van Heel DA Dechairo BM Dawson G McGovern DP Negoro K Carey AH Cardon LR Mackay I Jewell DP Lench NJ 《Human molecular genetics》2003,12(20):2569-2575
Genetic studies in inflammatory bowel disease have identified multiple susceptibility loci, whose relevance depends critically on verification in independent cohorts. Genetic variants associated with Crohn's disease have now been identified on chromosomes 5 (IBD5/5q31 risk haplotype) and 16 (IBD1 locus, CARD15/NOD2 mutations). Stratification of genome-wide linkage analyses by disease associated variants is now possible, offering both increased power for identification of other loci and improved understanding of genetic mechanisms. We performed a genome-wide scan of 137 Crohn's disease affected relative pairs from 112 families. Multipoint non-parametric linkage analyses were performed, with further stratification of affection status by common CARD15 mutations and the IBD5 haplotype. We verified linkage of Crohn's disease to regions on chromosome 3 (P=0.0009) and X (P=0.001) in our cohort. Linkage to chromosome 16 (IBD1) was observed in Crohn's disease pairs not possessing common CARD15 mutations (P=0.0007), approximately 25 cM q telomeric of CARD15. Evidence for linkage to chromosome 19 (IBD6) was observed in Crohn's disease pairs not possessing CARD15 mutations (P=0.0001), and in pairs possessing one or two copies of the IBD5 risk haplotype (P=0.0005), with significant evidence for genetic heterogeneity and epistasis, respectively. These analyses demonstrate the complex genetic basis to Crohn's disease, and show that the discovery of disease-causing variants may be used to aid identification of further susceptibility loci in complex disease. 相似文献
43.
Nishimura H Tokuyama K Arakawa H Ohki Y Sato A Kato M Mochizuki H Morikawa A 《International archives of allergy and immunology》2002,129(4):320-326
BACKGROUND: Chronic exposure to fenoterol (FEN), a beta(2)-adrenergic receptor (beta(2)-AR) agonist, was shown to induce both airway hyperresponsiveness and airway remodeling in experimental animals. OBJECTIVE: We wanted to know the effects of chronic exposure to procaterol (PRO), a beta(2)-AR agonist, on airway function and structure, because this agent is widely used as a bronchodilator in Japan. For comparison, the effects of FEN were also examined. METHODS: Aerosolized PRO (0.1 or 1 mg/ml), FEN (1 mg/ml) or vehicle (0.9% NaCl) was given to guinea pigs 3 times a day for 6 weeks. Sublaryngeal deposition of these agents was calculated using radioisotopes. At 72 h after the last inhalation of PRO, FEN or vehicle, the dose-response relationship between lung resistance (R(L)) and intravenously administered acetylcholine (ACh) was measured. After measuring R(L), histological changes in noncartilaginous airway dimensions were evaluated. RESULTS: The amount of sublaryngeal deposition of 0.1 mg/ml PRO in the present study was speculated to be 100 times larger than that of therapeutic dose. ACh concentrations causing 2-fold, 10-fold and maximal increases in R(L) were not different in 4 groups tested. In the smaller membranous airways (<0.4 mm in diameter), but not the larger ones, thickening of adventitial areas was significantly greater in animals treated with beta(2)-AR agonists than in control animals (23 and 25, and 96% higher in animals treated with 0.1 and 1 mg/ml PRO or 1 mg/ml FEN, respectively). The degree of the increase was significantly less in PRO-treated animals than in FEN-treated animals (p < 0.01). CONCLUSION: Our results did not provide any evidence that regular inhalation of PRO at the therapeutic dose might induce bronchial hyperresponsiveness. In addition, huge amounts of PRO only caused a mild thickening of the adventitial areas, suggesting that PRO may be a weak inducer of airway remodeling compared with FEN. 相似文献
44.
Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight 总被引:6,自引:5,他引:6
Benjamin D. Levine James A. Pawelczyk rew C. Ertl James F. Cox Julie H. Zuckerman ré Diedrich Italo Biaggioni Chester A. Ray Michael L. Smith Satoshi Iwase Mitsuru Saito Yoshiki Sugiyama Tadaaki Mano Rong Zhang Kenichi Iwasaki Lynda D. Lane Jay C. Buckey Jr William H. Cooke Friedhelm J. Baisch David Robertson Dwain L. Eckberg C. Gunnar Blomqvist 《The Journal of physiology》2002,538(1):331-340
45.
46.
47.
Kenichi Ohashi Yo Kato Jun Kanno Tsutomu Kasuga 《Virchows Archiv : an international journal of pathology》1990,417(2):137-143
Summary Normal oesophagus specimens taken from 65 autopsy cases and surgical specimens from 127 oesophageal carcinoma cases were examined
histopathologically to determine melanocyte incidence and distribution. Melanocytes were found in the epithelio-stromal junction
in 7.7% of normal oesophagus specimens examined at autopsy, and in 29.9% of surgical cases with oesophageal carcinoma. Positive
specimens in the latter groups, especially from pre-operatively irradiated individuals, showed a more remarkable increase
of melanocytes than was evident in any of the normal oesophageal samples. There were no significant differences in incidence
between males and females, or between age groups. In cases where the cancer invaded into deeper stroma, the melanocytes were
mainly observed in the normal epithelium around the carcinomas. Epithelial and stromal elements of the melanotic mucosa commonly
showed hyperplastic changes such as acanthosis or basal cell hyperplasia, and chronic oesophagitis. Melanocytes were observed
most commonly in the lower part of the oesophagus, the site where malignant melanoma of the oesophagus, most often originates.
These results strongly suggest that the melanocyte increase observed in areas of hyperplastic epithelium and chronic oesophagitis
may play an important role as a precursor lesion for malignant melanoma in the oesophagus. 相似文献
48.
Nakashima E Mabuchi A Kashimada K Onishi T Zhang J Ohashi H Nishimura G Ikegawa S 《American journal of medical genetics. Part A》2003,(3):253-256
We examined 12 Japanese patients with metaphyseal chondrodysplasia (MCD) for mutations in the ribonuclease mitochondrial RNA processing gene (RMRP), and identified four novel mutations in two patients with typical and atypical cartilage-hair hypoplasia (CHH), a form of MCD characterized by extra-skeletal manifestations including hypoplastic hair and defective immunity. A patient with typical CHH had a 17-bp duplication at +3 and a de novo 182G > A. The other patient with atypical CHH had a 17-bp insertion at -20 and a 218A > G. Expression analysis revealed that the allele with this insertion mutation in the promoter region silenced the gene. Spectrum analysis of the mutations and polymorphisms in RMRP showed marked difference between the Japanese and other ethnic groups. Such ethnic and phenotypic difference should be taken into account in mutation analysis of the gene. 相似文献
49.
Eiko Arai Shuichi Nishimura Kenichi Tamura Mitsushiro Kida Tatsuro Ikeuchi 《Journal of human genetics》1994,39(4):433-437
Summary Distal deletion of chromosome 1q has been reported in nearly 30 patients, all being associated with a deletion ranging from the 1q42 or q43 band to 1qter region. Here, we describe a girl with 1q terminal deletion resulting from an unbalancedde novo translocation t(1;D or G)(q44; p11), as revealed by the presence of a satellited feature and an NOR-stained region at the tip of 1q. We suggest that most of the phenotypic abnormalities seen in patients with 1q distal deletion are attributable to the monosomy for band 1q44. 相似文献
50.
Kenichi Wakasa Masami Sakurai Morito Monden Tsuyoshi Yamada Chikazumi Kuroda Taro Marukawa Jun Okamura 《Pathology international》1988,38(10):1363-1367
We describe a case of hepatocellular carcinoma in which a tumor embolus in the portal vein and 3 of 4 intrahepatic metastases were necrosed completely by Lipiodol transcatheter chemo-embolization (Lipiodol-TCE). Tumor emboli in the portal vein and intrahepatic metastases usually cannot be necrosed by conventional transcatheter chemo-embolization alone, because small nodules such as intrahepatic metastases and tumor emboli in the portal vein are supplied blood from the portal vein. However, in this case, Lipiodol-TCE was effective against tumor emboli in the portal vein and intrahepatic metastases. ACTA PATHOL JPN 38: 1363-1367, 1988. 相似文献