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31.
A. I. Fink A. J. Jordan P. N. Lao D. A. Fong 《The British journal of ophthalmology》1988,72(4):263-269
Sixty-one patients (82 eyes) were studied after argon laser trabeculoplasty (ALT) to determine the lasting efficacy of such treatment. This investigation, now in its fourth year, was prospective, and the information derived was analysed with the aid of a computer. Success was defined as intraocular pressure (IOP) below baseline (22 mmHg). The mean follow-up time was 24.5 months, when the success rate was 74% compared with 75% at three months. Success declined to 45% at 42 months. No significant difference was noted when (a) first lasered eyes of all patients and those fellow eyes treated were analysed separately, (b) when right and left eyes were analysed separately, nor (c) when patients were divided into two treatment groups, (I) 100 burns at 1 W, and (II) 65 burns at 850 mW. Eight of 11 eyes showed progressive postlaser field loss despite below-baseline intraocular pressures. ALT is an alternative to carbonic anhydrase inhibitor therapy, with a success rate of 66.7% at two years. However, repeat ALT was successful in only 25% of patients seven months after treatment. 相似文献
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BACKGROUND: The treatment of orbital wall fractures involves observation and/or surgical reduction with repositioning of herniated orbital tissues. To prevent reherniation of tissue and development of enophthalmos, the orbital floor or wall defect is commonly covered with an alloplastic implant. Complications associated with these implants are infrequent and generally appear as isolated case reports. METHODS: The authors reviewed the files of four consultative oculoplastic surgeons and searched for individuals with complications secondary to their alloplastic implants used during orbital fracture repair. FINDINGS: Seventeen patients were identified with a variety of complications related to their alloplastic implant. CONCLUSION: Although these implants are relatively inert and develop a fibrous capsule walling them off from the surrounding orbit, they remain foreign bodies and are thus subject to possible complications at any time. The authors review the spectrum of complications occurring with various alloplastic implants. 相似文献
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Mark A. Beilke Debra Riding In Rebecca Hamilton Gary A. Stone Elaine K. Jordan Gene Brashears Wayne Nusbaum David Huddleston Clarence J. Gibbs Jr. Maneth Gravell 《Journal of neuroimmunology》1991,33(2):129-143
HLA-DR expression in neuroendothelial cells (NEC) was studied during the course of SIV encephalitis in rhesus monkeys. HLA-DR determinants were detected on NEC in monkeys with SIV encephalitis, but not in control animals. In situ hybridization with an SIV probe indicated that HLA-DR expression was not a consequence of SIV replication within NEC. Cultured rhesus NEC stimulated with gamma interferon expressed HLA-DR to a higher degree than cultured brain fibroblasts or astrocytes. These data support the contention that NEC participate in retrovirus-induced inflammation and autoimmunity within the central nervous system. 相似文献
36.
Jens Jordan 《Clinical autonomic research》2007,17(6):331-333
Genes influencing the autonomic nervous system continue as a focus of research. Recent publications applied different methods
to identify genes influencing autonomic cardiovascular regulation in humans. Two reports relied on a candidate gene approach.
Common genetic polymorphisms in the promoter region of the tyrosine hydroxylase gene were shown to influence catecholamine
synthesis and blood pressure. The same group tested the hypothesis that the GTP cyclohydrolase 1 (GCH1) gene influences catecholamine
excretion and cardiovascular regulation. GCH1 affects tyrosine hydroxylase function indirectly. The authors concluded that
the GCH1 gene may influence cardiovascular autonomic regulation through changes in nitric oxide production rather than a change
in tyrosine hydroxylase activity. The third genetic study used a single nucleotide polymorphism chip to analyze 100,000 genetic
polymorphisms scattered throughout the genome in participants of the Framingham study. The authors identified several polymorphisms
that may influence QT interval duration, heart rate, and heart rate variability. The respective genes have not been identified
with certainty. Another study suggested that catecholamines may be released from phagocytes and regulate pulmonary inflammation
through alpha-2 adrenoreceptor activation in an autocrine or paracrine fashion. 相似文献
37.
Ducklings on a problem farm which showed persistent and unacceptably high mortality yielded a larger range and greater number of viruses than did ducklings from a second flock, in which mortality was of a power and acceptable level. Reoviruses were the viruses most frequently isolated from young birds from both farms, but for longer at the problem site. ELAs (Embryo Lethal Agents), named since they caused high mortality in chick embryos, but could not otherwise be characterized, were recovered frequently and throughout the growth cycle of the problem flock, but not at all in the other flock. Lentogenic Newcastle disease virus was detected at all ages on the problem farm but less often than ELAs. The faeces of birds on the problem farm yielded rota-like viruses, corona-like viruses and adeno-like viruses, and on the farm with normal mortality, Egg Drop Syndrome-76 virus and adenovirus. Detection techniques included culture on chick embryos and chick embryo liver cells, and electron microscopy (EM). Inoculation of whole eggs was particularly valuable and more successful than cell culture for virus recovery. EM was most useful for direct examination of faecal preparations and confirmation of the viral type. 相似文献
38.
T. Bendix A. F. Bendix E. Busch A. Jordan Tom Bendix MD 《Scandinavian journal of medicine & science in sports》1996,6(2):88-97
Conventional treatments have not slowed down the ever expanding low back pain (LBP) problem. Traditional treatment has most probably contributed to the growth of the problem. Therefore, in a search for new solutions, 'functional restoration' has been devised. In connection with chronic LBP the term has been associated with a full-day program lasting from 3 to 5 weeks. it includes multidisciplinary treatment of patients in groups with intensive physical and ergonomic training, psychological pain management, back school, as well as teaching in social/work related issues. The key concepts are 'acceptance of the pain', 'activity', 'self-responsibility', 'multidisciplinary' and 'quantitative functional evaluation (QFE)'. The latter is aimed so that the participants can feel the physical improvement, encouraging them to be able to go back to work, or at least to lead a more active life style. Several controlled studies suggest a lasting effect in terms of regaining their ability to work and improving pain behavior for a good part of disabled chronic LBP patients. However, it is noteworthy that randomized studies seemingly show poorer results than studies not employing randomized controls. 相似文献
39.
PCR amplification introduces errors into mononucleotide and dinucleotide repeat sequences. 总被引:3,自引:0,他引:3
The polymerase chain reaction (PCR) is used universally for accurate exponential amplification of DNA. We describe a high error rate at mononucleotide and dinucleotide repeat sequence motifs. Subcloning of PCR products allowed sequence analysis of individual DNA molecules from the product pool and revealed that: (1) monothymidine repeats longer than 11 bp are amplified with decreasing accuracy, (2) repeats generally contract during PCR because of the loss of repeat units, (3) Taq and proofreading polymerase Pfu generate similar errors at mononucleotide and dinucleotide repeats, and (4) unlike the parent PCR product pool, individual clones containing a single repeat length produce no "shadow bands". These data demonstrate that routine PCR amplification alters mononucleotide and dinucleotide repeat lengths. Such sequences are common components of genetic markers, disease genes, and intronic splicing motifs, and the amplification errors described here can be mistaken for polymorphisms or mutations. 相似文献
40.