全文获取类型
收费全文 | 20292篇 |
免费 | 1274篇 |
国内免费 | 57篇 |
专业分类
耳鼻咽喉 | 330篇 |
儿科学 | 1104篇 |
妇产科学 | 497篇 |
基础医学 | 1776篇 |
口腔科学 | 354篇 |
临床医学 | 1582篇 |
内科学 | 4856篇 |
皮肤病学 | 328篇 |
神经病学 | 1032篇 |
特种医学 | 720篇 |
外科学 | 3681篇 |
综合类 | 449篇 |
一般理论 | 3篇 |
预防医学 | 1080篇 |
眼科学 | 875篇 |
药学 | 1543篇 |
1篇 | |
中国医学 | 71篇 |
肿瘤学 | 1341篇 |
出版年
2023年 | 144篇 |
2022年 | 222篇 |
2021年 | 759篇 |
2020年 | 404篇 |
2019年 | 605篇 |
2018年 | 705篇 |
2017年 | 493篇 |
2016年 | 499篇 |
2015年 | 505篇 |
2014年 | 785篇 |
2013年 | 990篇 |
2012年 | 1487篇 |
2011年 | 1347篇 |
2010年 | 848篇 |
2009年 | 665篇 |
2008年 | 999篇 |
2007年 | 1015篇 |
2006年 | 944篇 |
2005年 | 881篇 |
2004年 | 788篇 |
2003年 | 675篇 |
2002年 | 599篇 |
2001年 | 479篇 |
2000年 | 510篇 |
1999年 | 403篇 |
1998年 | 161篇 |
1997年 | 138篇 |
1996年 | 117篇 |
1995年 | 116篇 |
1994年 | 104篇 |
1993年 | 82篇 |
1992年 | 279篇 |
1991年 | 250篇 |
1990年 | 219篇 |
1989年 | 211篇 |
1988年 | 172篇 |
1987年 | 176篇 |
1986年 | 155篇 |
1985年 | 168篇 |
1984年 | 147篇 |
1983年 | 141篇 |
1982年 | 65篇 |
1981年 | 75篇 |
1979年 | 116篇 |
1978年 | 86篇 |
1977年 | 63篇 |
1974年 | 75篇 |
1973年 | 110篇 |
1972年 | 100篇 |
1971年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
Holly D. Mitchell Tatiana Garcia Vilaplana Sema Mandal Natasha Ratna Megan Glancy Ammi Shah Ruth Simmons Celia Penman Freja Kirsebom Annastella Costella Alison E. Brown Hamish Mohammed Valerie Delpech Katy Sinka Gwenda Hughes 《Emerging infectious diseases》2022,28(3):739
Since the coronavirus disease pandemic response began in March 2020, tests, vaccinations, diagnoses, and treatment initiations for sexual health, HIV, and viral hepatitis in England have declined. The shift towards online and outreach services happened rapidly during 2020 and highlights the need to evaluate the effects of these strategies on health inequalities. 相似文献
993.
Nabil Hajji Juan Garcia-Revilla Manuel Sarmiento Soto Richard Perryman Jake Symington Chad C. Quarles Deborah R. Healey Yijie Guo Manuel Luis Orta-Vzquez Santiago Mateos-Cordero Khalid Shah John Bomalaski Giulio Anichini Andreas G. Tzakos Timothy Crook Kevin ONeill Adrienne C. Scheck Jose Luis Venero Nelofer Syed 《The Journal of clinical investigation》2022,132(6)
New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine-depleting agent ADI-PEG20 in a non-arginine-auxotrophic cellular background (argininosuccinate synthetase 1 positive). Moreover, this combination led to durable and complete radiological and pathological response, with extended disease-free survival in an orthotopic immune-competent model of GBM, with no significant toxicity. ADI-PEG20 not only enhanced the cellular sensitivity of argininosuccinate synthetase 1–positive GBM to ionizing radiation by elevated production of nitric oxide (˙NO) and hence generation of cytotoxic peroxynitrites, but also promoted glioma-associated macrophage/microglial infiltration into tumors and turned their classical antiinflammatory (protumor) phenotype into a proinflammatory (antitumor) phenotype. Our results provide an effective, well-tolerated, and simple strategy to improve GBM treatment that merits consideration for early evaluation in clinical trials. 相似文献
994.
Arantza Perez-Valle Begoa Ochoa Krushangi N. Shah Gabriel Barreda-Gomez Egoitz Astigarraga María Dolores Boyano Aintzane Asumendi 《Oncology Letters》2022,23(5)
The incidence rates of melanoma have increased steadily in recent decades and nearly 25% of the patients diagnosed with early-stage melanoma will eventually develop metastasis, for which there is currently no fully effective treatment. The link between phospholipases and tumors has been studied extensively, particularly in breast and colon cancers. With the aim of finding new biomarkers and therapeutic options for melanoma, the expression of different phospholipases was assessed in 17 distinct cell lines in the present study, demonstrating that phospholipase D2 (PLD2) is upregulated in metastatic melanoma as compared to normal skin melanocytes. These results were corroborated by immunofluorescence and lipase activity assays. Upregulation of PLD2 expression and increased lipase activity were observed in metastatic melanoma relative to normal skin melanocytes. So far, the implication of PLD2 activity in melanoma malignancies has remained elusive. To the best of our knowledge, the present study was the first to demonstrate that the overexpression of PLD2 enhances lipase activity, and its effect to increase the proliferation, migration and invasion capacity of melanoma cells was assessed with XTT and Transwell assays. In addition, silencing of PLD2 in melanoma cells reduced the metastatic potential of these cells. The present study provided evidence that PLD2 is involved in melanoma malignancy and in particular, in its metastatic potential, and established a basis for future studies evaluating PLD2 blockade as a therapeutic strategy to manage this condition. 相似文献
995.
Imtiaz Alam Shah Rafiullah Khan Seyed Saeid Rahimian Koloor Michal Petr Saeed Badshah Sajjad Ahmad Muhammad Amjad 《Materials》2022,15(6)
In this study, the ballistic impact behavior of auxetic sandwich composite human body armor was analyzed using finite element analysis. The auxetic core of the armor was composed of discrete re-entrant unit cells. The sandwich armor structure consisted of a front panel of aluminum alloy (Al 7075-T6), UHMWPE (sandwich core), and a back facet of silicon carbide (SiC) bonded together with epoxy resin. Numerical simulations were run on Explicit Dynamics/Autodyne 3-D code. Various projectile velocities with the same boundary conditions were used to predict the auxetic armor response. These results were compared with those of conventional monolithic body armor. The results showed improved indentation resistance with the auxetic armor. Deformation in auxetic armor was observed greater for each of the cases when compared to the monolithic armor, due to higher energy absorption. The elastic energy dissipation results in the lower indentation in an auxetic armor. The armor can be used safely up to 400 m/s; being used at higher velocities significantly reduced the threat level. Conversely, the conventional monolithic modal does not allow the projectile to pass through at a velocity below 300 m/s; however, the back face becomes severely damaged at 200 m/s. At a velocity of 400 m/s, the front facet of auxetic armor was destroyed; however, the back facet was completely safe, while the monolithic panel did not withstand this velocity and was completely damaged. The results are encouraging in terms of resistance offered by the newly adopted auxetic armor compared to conventional monolithic armor. 相似文献
996.
997.
Statins are an extensively used class of drugs, and myopathy is an uncommon, but well-described side effect of statin therapy. Inflammatory myopathies, including polymyositis, dermatomyositis, and necrotizing autoimmune myopathy, are even more rare, but debilitating, side effects of statin therapy that are characterized by the persistence of symptoms even after discontinuation of the drug. It is important to differentiate statin-associated inflammatory myopathies from other self-limited myopathies, as the disease often requires multiple immunosuppressive therapies. Drug interactions increase the risk of statin-associated toxic myopathy, but no risk factors for statin-associated inflammatory myopathies have been established. Here we describe the case of a man, age 59 years, who had been treated with a combination of atorvastatin and gemfibrozil for approximately 5 years and developed polymyositis after treatment with omeprazole for 7 months. Symptoms did not resolve after discontinuation of the atorvastatin, gemfibrozil, and omeprazole. The patient was treated with prednisone and methotrexate followed by intravenous immunoglobulin, which resulted in normalization of creatinine kinase levels and resolution of symptoms after 14 weeks. It is unclear if polymyositis was triggered by interaction of the statin with omeprazole and/or gemfibrozil, or if it developed secondary to long-term use of atorvastatin only. 相似文献
998.
999.
Maternal and Child Health Journal - To examine recent rates of long-acting and permanent methods (LAPM) of contraception use during delivery hospitalization and correlates of their use. A... 相似文献
1000.
The commonly used Darling classification for total anomalous pulmonary venous connection (TAPVC) consists of supracardiac,
cardiac, infracardiac, and mixed types (Craig et al., Lab Invest 6:44–64, 1967). In supracardiac TAPVC, the common pulmonary vein drains superiorly into the left innominate vein, the superior vena cava,
or the azygos vein by way of an ascending vertical vein. We describe a case of supracardiac TAPVC draining into the azygos
vein atypically by way of a descending vertical vein. 相似文献