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101.
102.
Olivia Fletcher Lorna Gibson Nichola Johnson Dan R Altmann Jeffrey M P Holly Alan Ashworth Julian Peto Isabel Dos Santos Silva 《Cancer epidemiology, biomarkers & prevention》2005,14(1):2-19
We reviewed all English-language articles on associations among circulating levels of the insulin-like growth factors (IGF) and their binding proteins (IGFBP), polymorphisms in their genes, and breast cancer risk. In premenopausal women, five of eight IGF-I studies and four of six IGFBP-3 studies of circulating levels found that women in the highest quantile had more than twice the risk of developing breast cancer of those in the lowest, although in some this effect was only apparent at young ages. In postmenopausal women, however, there was no consistent effect. A simple sequence length polymorphism 1 kb 5' to IGF-I was examined in relation to circulating levels of IGF-I (12 studies) or breast cancer risk (4 studies), but there was no convincing evidence of any effect. For an A/C polymorphism 5' to IGFBP-3, all three studies were consistent with a modest effect on circulating levels, but no evidence of a direct effect on breast cancer risk was seen in the only relevant study. Variation within the reference range of IGF-I and IGFBP-3 may confer only modest increases in breast cancer risk, and any single polymorphism may only account for a small proportion of that variation. Nevertheless, population attributable fractions for high circulating levels of IGF-I and IGFBP-3 and for common genetic variants could be substantial. Further large studies, or combined analysis of data from existing studies, are needed to quantify these effects more precisely. 相似文献
103.
Isabel Monteiro-Grillo Pedro Marques-Vidal Marília Jorge 《Clinical & translational oncology》2005,7(11):499-503
Purpose To compare the quality-of-life (QoL) and psycho-social changes in a group of patients with early breast cancer who underwent
conservative surgery (BCS) or modified radical mastectomy (MRM).
Methods Self-administered questionnaire assessing body image perception, social habits, sexual attraction and self-consciousness with
relatives/friends, was randomly assigned to 125 patients (61 BCS, 64 MRM; aged 53±8 and 50±9 years, respectively, p=NS).
Results MRM patients reported a significantly higher frequency of changes in body image perception and other related social behaviour
such as avoiding going to the beach or using low-cut clothes, and reticence with friends. Conversely, no differences were
found regarding sexuality, denial of the disease by the husband/partner, or concealing the disease from family members. Also,
no significant differences were found between patients above and below the age of 50 years, for all variables studied after
adjustment for surgical procedure.
Conclusions Modified radical mastectomy has a negative effect on body image perception and in social behaviour patterns of patients and
with a concomitant decrease in QoL. The sexuality of the patient is not significantly affected. 相似文献
104.
The diagnostic usefulness of sentinel lymph node biopsy (SLNB) has been well established, but its therapeutic value remains
unproven. First introduced by Morton and colleagues, the SLNB procedure is now widely available, and markedly enhances our
ability to pathologically stage the regional nodes.
Although the SLN status is acknowledged as the most powerful indicator of prognosis in melanoma, there is no evidence to-date,
of survival advantage for complete lymphadenectomy in SLN-positive patients. Also, there is no effective adjuvant therapy
that could benefit these sentinel node-positive patients, as yet. Additionally, new data have emerged indicating a possible
increase in local/in-transit recurrence following complete lymphadenectomy in sentinel node-positive patients. To understand
fully and to evaluate these observations we need information from randomized controlled trials.
Major changes have occurred following the latest revision of melanoma staging system (AJCC, 6th edition). Concerning N category,
these include the incorporation of the number of metastatic lymph nodes, the tumour burden of nodal metastases, and the ulceration
of the primary tumour. The data obtained from the new staging system will reflect differences in prognosis that were not previously
emphasized and which, we hope, will serve as a guide to more accurate analysis of metastatic pathways in cutaneous melanoma
as well as a rationale for new forms of treatment. 相似文献
105.
106.
Over the last years, ambulatory blood pressure monitoring has been introduced into the pediatric population, contributing to a significant increase in the bulk of knowledge of crucial clinically relevant issues. Guidelines have established the currently known conditions where ambulatory blood pressure monitoring is useful and where it will provide additional information in children and adolescents. How common and important the intra-individual differences are within clinical and ambulatory blood pressure is the keystone to the use of ambulatory blood pressure monitoring as a diagnostic tool. By using not only office, but also ambulatory blood pressure, four possible situations arise. Two of these have values in agreement for normotension or hypertension. Two have values that are discrepant. The latter two are known as white coat and masked hypertension. The relationship with hypertension-induced organ damage, the prognostic value and the assessment of treatment goals are key issues of ambulatory blood pressure monitoring. In children, the accurate identification of hypertension at the earliest possible age would, therefore, give health-care providers the opportunity to initiate preventive measures, thereby reducing the chance of developing end-organ damage and its attendant morbidity and mortality. 相似文献
107.
108.
109.
Natalia Curto-García Julio García-Suárez Marta Callejas Chavarria Juan José Gil Fernández Yolanda Martín Guerrero Elena Magro Mazo Shelly Marcellini Antonio Luis Miguel Juárez Isabel Gutierrez Juan José Arranz Irene Montalvo Carmen Elvira Pilar Domínguez María Teresa Díaz Carmen Burgaleta 《Supportive care in cancer》2016,24(1):93-101
110.