全文获取类型
收费全文 | 273614篇 |
免费 | 13538篇 |
国内免费 | 593篇 |
专业分类
耳鼻咽喉 | 3521篇 |
儿科学 | 8372篇 |
妇产科学 | 5994篇 |
基础医学 | 38990篇 |
口腔科学 | 6407篇 |
临床医学 | 21923篇 |
内科学 | 60887篇 |
皮肤病学 | 7089篇 |
神经病学 | 24747篇 |
特种医学 | 8503篇 |
外国民族医学 | 106篇 |
外科学 | 33604篇 |
综合类 | 1263篇 |
一般理论 | 73篇 |
预防医学 | 25325篇 |
眼科学 | 5116篇 |
药学 | 19048篇 |
中国医学 | 837篇 |
肿瘤学 | 15940篇 |
出版年
2023年 | 1429篇 |
2022年 | 1511篇 |
2021年 | 4904篇 |
2020年 | 2771篇 |
2019年 | 4966篇 |
2018年 | 9690篇 |
2017年 | 6305篇 |
2016年 | 5763篇 |
2015年 | 6251篇 |
2014年 | 7115篇 |
2013年 | 11054篇 |
2012年 | 18334篇 |
2011年 | 18430篇 |
2010年 | 9469篇 |
2009年 | 7482篇 |
2008年 | 15745篇 |
2007年 | 16685篇 |
2006年 | 15435篇 |
2005年 | 15276篇 |
2004年 | 14377篇 |
2003年 | 13232篇 |
2002年 | 12452篇 |
2001年 | 6906篇 |
2000年 | 7067篇 |
1999年 | 6252篇 |
1998年 | 1359篇 |
1997年 | 1075篇 |
1996年 | 988篇 |
1995年 | 900篇 |
1992年 | 3580篇 |
1991年 | 3180篇 |
1990年 | 3045篇 |
1989年 | 2777篇 |
1988年 | 2591篇 |
1987年 | 2459篇 |
1986年 | 2305篇 |
1985年 | 2086篇 |
1984年 | 1570篇 |
1983年 | 1318篇 |
1979年 | 1345篇 |
1978年 | 966篇 |
1977年 | 902篇 |
1975年 | 909篇 |
1974年 | 1089篇 |
1973年 | 1117篇 |
1972年 | 1043篇 |
1971年 | 1019篇 |
1970年 | 944篇 |
1969年 | 981篇 |
1968年 | 879篇 |
排序方式: 共有10000条查询结果,搜索用时 484 毫秒
991.
Sergio Luís Blay Sergio Baxter Andreoli Fábio Leite Gastal 《Annals of clinical psychiatry》2007,19(3):169-174
BACKGROUND: The main purpose of this study is to investigate the association of disturbed sleep, chronic physical pain and psychiatric morbidity in people aged 60 years and over. METHODS: A population-based random sample of 7040 household residents aged 60 years and over, was examined in a face-to-face interview. Painful medical conditions were assessed through questions evaluating medical treatment, hospitalizations, and consultations for medical problems. Disturbed sleep was assessed through questions concerning the presence of sleeping problems in the past 4 weeks. RESULTS: The overall prevalence of disturbed sleep is 33.7% (95% CI: 32.5-34.8) and the 6-month prevalence of any chronic pain was 76.2% (95% CI: 74.2-78.2%). A substantial burden of disturbed sleep is associated with the presence of physical pain morbidity, 42.5% for back pain to 49.7% for headaches. The prevalence of pain among persons with disturbed sleep ranges from 25.8% for gastrointestinal pain to 54.6% for joint pain. The presence of comorbid pain and disturbed sleep has an important disability impact as assessed by socioecomomic/professional data, health care utilization, self-rated health and physical activity. In logistic regression models, headaches, psychiatric morbidity, rural origin, Caucasians, self-rated health and number of chronic pain conditions were significantly associated with disturbed sleep after controlling for demographic variables and comorbidities. Age has a negative effect on sleep complaints. CONCLUSIONS: Disturbed sleep is highly comorbid with other pain conditions particularly headaches and psychiatric morbidity in later life. The combination of pain and disturbed sleep leads to important role disability and increased utilization of medical services. 相似文献
992.
L F Pérez Méndez E Alvarez-García P Alvarez-Vázquez E Hervás A Casterás L Fajar R V García-Mayor 《Experimental and clinical endocrinology & diabetes》2007,115(3):182-186
AIM: To evaluate if intensive insulin regimen with multiple daily injections (MDI) is successful for treating type 1 diabetes patients over a long period of time in a regular clinical setting. METHOD: This is a prospective, observational seven-year study. Fifty-nine (35 male) type 1 diabetic patients with bad metabolic control (HbA1c> or =9%), aged 31.9 years, range 18-47 were included in the present study. All of them had had at least 5 years of diabetes duration after diagnosis and showed negative responses of serum C-peptide to a standard breakfast. The main control variables are: Metabolic control measured by serum HbA1c values (values < 6.2 % was the treatment objective) and the frequency of hypoglycaemic episodes (episodes/patient-month). RESULTS: Significant decreases in mean+/-SD HbA1c values in this group of patients were observed from the first year of follow-up, with the mean values being: 7.5+/-1.5%, 7.2+/-1.8%, 7.6+/-1.6%, 7.1+/-1.7%, 7+/-1.4, 6.6+/-1.6% and 6.8+/-1.4% for the first, second, third, fourth, fifth, sixth and seventh years of follow-up respectively. Sixteen %, 27.5%, 15.7%, 33.3%, 28.6%, 42% and 33% of the patients reached the treatment objective (HbA1c values<6.2%) for each year of follow-up. Throughout the study period the rate of severe hypoglycaemia (episodes/patient-year) was 0.32+/-0.2 which was not significantly different compared with the value of 0.28+/-0.1 observed the year before the study began. Similarly frequencies of mild/moderate hypoglycaemia episodes (episodes/patient-month) varies between 16.5+/-4 and 21.7+/-5, which are not significantly different from the value of 17.7+/-6 observed the year before the study began. CONCLUSION: Long-term improvement in metabolic control was observed in this group of type 1 diabetes patients with previous bad control, during treatment in a regular clinical setting. A considerable percentage of type 1 diabetic patients with MDI reached the treatment objective in every year of follow-up. Furthermore improvement in metabolic control is not associated with significantly increased frequency of hypoglycaemia episodes. 相似文献
993.
994.
Gil Bellis Marie-Hélène Cazes Alain Parant Maryse Gaimard Cécile Travers Evelyne Le Roux Sophie Ravilly Gilles Rault 《Journal of cystic fibrosis》2007,6(3):179-186
BACKGROUND: In 1992 France set up a national cystic fibrosis observatory (Observatoire national de la mucoviscidose, ONM) to monitor the state of health of patients on an annual basis. Using the ONM data, this study estimates the main indicators for life expectancy and assesses the total number of cystic fibrosis patients. METHODS: The data for the years 1994 to 2003 are divided into 3-year periods. Life tables are drawn up for these periods, from which mean and median lengths of life are determined. Using the most recent life table, the number of births in 2003 and the incidence of the disease, the total population of patients can be estimated, assuming a stationary population. RESULTS: In 2001-2003, life expectancy at birth of patients registered with the ONM was 39.1 years and median length of life was 36.4 years. These results, substantially better than those of 1994-1996, are linked to improved conditions of patient inclusion in the ONM database, to improvements in their healthcare, but also to the limitations of the life tables. Based on the 2003 data, the total theoretical number of patients is 6490, and coverage by the ONM database is thus 63.2%. CONCLUSIONS: These provisional results demonstrate the need to convert the ONM observatory into a registry providing exhaustive coverage of all patients. 相似文献
995.
Homid Fahandezh-Saddi Díaz Antonio Ríos-Luna Eduardo García-Rey Ma Jesus Rodea Butragueño Manuel Villanueva-Martinez Ma Elena Cantero-Yubero Miguel del Cerro-Gutiérrez 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2007,17(1):105-109
Treatment of chronic osteomyelitis of distal tibia is complex. It often requires the association of antibiotic therapy and a surgical procedure. This consists of exhaustive debridement of infected bone and soft tissue which must have adequate cutaneous coverage and vascular supply which enables creating a barrier to microorganisms and greater resistance to infection. Free or pedicled muscular flaps have been the techniques most often used for this type of lesions. Free flaps require a precise microsurgical technique and prolonged surgery. Pedicled muscular flaps do not provide sufficient coverage and vascularisation of the distal tibia for large size defects. The fasciocutaneous flap has been used for the treatment of coverage defects in the perimalleolar area and the heel. We report the utility of this flap as management of chronic osteomyelitis of the distal third of the tibia with complete healing of the infection and correct cutaneous coverage without complications. 相似文献
996.
Kathy Dujardin Pascal Sockeel David Devos Marie Delliaux Pierre Krystkowiak Alain Destée Luc Defebvre 《Movement disorders》2007,22(6):778-784
The objective of this study was to use the Lille Apathy Rating Scale to assess apathy in a large population of Parkinson's disease (PD) patients and identify several different apathy profiles. One hundred fifty-nine patients with probable PD and 58 healthy controls participated in the study. Apathy was assessed using the Lille Apathy Rating Scale. Motor, cognitive, and depressive symptoms were rated on standardized scales. Data were analyzed using linear regression and multivariate analyses of variance. Thirty-two percent of the PD patients were classified as apathetic. Apathy was more frequent in patients with dementia. The four apathy dimensions contributed differently to the overall severity of the apathetic condition. Action initiation and intellectual curiosity had a marked influence. Linear regression analysis revealed that the apathy level was mainly determined by cognitive impairment, not associated with the severity of motor symptoms, and only associated with the apathy subcomponent of the Montgomery and Asberg Depression Rating Scale. Apathy is highly prevalent in PD patients. Apathy profiles vary according to the clinical presentation of PD. The high prevalence of apathy in PD suggests the involvement of frontal-subcortical circuits. Although the neurochemical substrate of apathy remains poorly characterized, the strong link between apathy and cognitive impairment observed in several studies suggests the participation of nondopaminergic circuits. 相似文献
997.
998.
Dr. Em. N. v. Regéczy 《Pflügers Archiv : European journal of physiology》1883,30(1):544-595
Ohne Zusammenfassung 相似文献
999.
Luís Sargento Dulce Brito J Sampaio Matias Hugo Madeira 《Revista portuguesa de cardiologia》2007,26(7-8):717-726
INTRODUCTION: Levosimendan is an inodilatory drug with hemodynamic effects in patients with decompensated chronic heart failure. AIM: Short-term (one month) evaluation of clinical, hemodynamic and neurohormonal changes in patients with decompensated chronic heart failure undergoing levosimendan therapy. METHODS: Twenty-six (21 male) consecutive patients were studied, corresponding to 32 levosimendan administrations (bolus + 24h infusion), aged 56.7+/-13.0 years, with decompensated chronic heart failure, in NYHA functional class III-IV (78.1% in class IV), and cardiac index (CI) <2.5 l/min/m2. Clinical (NYHA class), non-invasive hemodynamic (echocardiography) and neurohormonal (Elecsys ECLIA NT-ProBNP) evaluations were performed before levosimendan administration and on days 1, 4, 10 and 30. RESULTS: 1) Until day 10, there was a progressive decrease in NT-ProBNP values and weight (p<0.001), with an increase in CI (p<0.001); 2) NYHA functional class improved progressively, with 76% of the patients in NYHA class II at day 30; 3) NT-ProBNP values at day 1 correlated inversely (r=-0.414; p=0.024) with CI at day 4; and 4) the absolute decrease in NT-ProBNP values at day 4 (relative to baseline values) correlated with weight loss at day 4 (r=0.495, p=0.005), day 10 (r=0.424, p=0.031) and day 30 (r=0.486, p=0.030). CONCLUSION: Levosimendan therapy in patients with decompensated chronic heart failure contributes to progressive NYHA class improvement. The variations seen in NYHA class and hemodynamics was reflected in changes in NT-ProBNP. 相似文献
1000.
S Huez F Roufosse J-L Vachiéry A Pavelescu G Derumeaux J-C Wautrecht E Cogan R Naeije 《The European respiratory journal》2007,30(5):928-936
Right ventricular function is frequently abnormal in patients with systemic sclerosis, but whether this is related to pulmonary vascular complications of the disease is unclear. Standard echocardiography with tissue Doppler imaging was performed at rest and during exercise for the study of right ventricular function and pulmonary circulation in 25 consecutive systemic sclerosis patients and in 13 age-matched healthy controls. When compared with the controls, the patients had no difference in systolic right ventricular pressure gradient, but a decreased pulmonary flow acceleration time, and increased right ventricular free wall thickness and end-diastolic dimensions. At the tricuspid annulus, the E maximal velocity was decreased (8.9 +/- 4 versus 11.7 +/- 2.3 cm.s(-1)) and the isovolumic relaxation time corrected to RR interval was increased (6.5 +/- 2.9 versus 4.5 +/- 2.5%). The tissue Doppler imaging profile at the mitral annulus was similar in both groups. At exercise, 18 patients had a decreased maximum workload and cardiac output, no change in systolic right ventricular pressure gradient, but an increase in the slope of pulmonary artery pressure/flow relationships. These results suggest that patients with systemic sclerosis may present with latent pulmonary hypertension as a likely cause of right ventricular diastolic dysfunction, as revealed by stress echocardiography and tissue Doppler imaging. 相似文献