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排序方式: 共有561条查询结果,搜索用时 296 毫秒
71.
72.
K Hamada M Kunimatsu H Katada K Mikasa M Sawaki N Narita T Imai R Mikami 《Nihon Kyōbu Shikkan Gakkai zasshi》1988,26(11):1154-1160
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74.
Nakatani K Tanabe S Nishimura K Shimoda T Azuma M Katada C Sasaki T Higuchi K Koizumi W Saigenji K 《Gan to kagaku ryoho. Cancer & chemotherapy》2006,33(7):997-1000
A 78-year-old woman was admitted to our hospital because of tarry stools. A gastric stromal tumor with liver metastasis was diagnosed. Treatment with imatinib mesilate was begun in a dose of 400 mg daily. After 1 month, the primary tumor showed a partial response; the response of the liver metastasis was stable disease. However, grade 2 edema, leukocytopenia, and anemia developed, and the dose of imatinib mesilate was reduced to 200 mg daily. The adverse reactions resolved promptly, and a partial response of both the primary tumor and liver metastasis to imatinib mesilate has been maintained for 28 months. Strategies for lowering the dose of imatinib mesilate are reviewed. 相似文献
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77.
CT in evaluation of the circle of Willis 总被引:1,自引:0,他引:1
Summary The method of visualizing the circle of Willis intentionally on contrast-enhanced CT scan was studied. The incidence of circle of Willis in our series was 86%. Only mild side effects were observed, in 7.5% of cases. CT of 60 proven cerebral aneurysms were reviewed and aneurysm was detected in 57%. This method has the potential to be a noninvasive screening procedure for evaluation of suspected cerebral aneurysm, as well as evaluation of marked arteriosclerosis, occlusion of major arteries, and mass effect of parasellar tumors. 相似文献
78.
T Sawada T Oinuma H Katada M Saitoh I Sakurai 《Rinsho byori. The Japanese journal of clinical pathology》1992,40(11):1179-1184
A silver colloid staining technique for identifying nucleolar organizer region-associated proteins (Ag-NORs) was applied to 17 primary gliomas and 16 meningiomas. These comprised 8 glioblastomas, one pleomorphic xanthoastrocytoma, 8 benign astrocytoma, 10 nonrecurrent meningiomas and 6 recurrent meningiomas, in which the mean number of Ag-NORs' per nuclei, were 3.37, 2.34, 2.57, 2.16 and 2.80 respectively, identifying significant differences among these groups. Ag-NORs of four giant cell glioblastomas showed low numbers of Ag-NORs, suggesting better prognosis. In spite of the time consuming and complicated counting method Ag-NORs is reproductive and useful as a tool for estimating the proliferating potential of various brain tumors, and appears to widely applicable in clinical laboratories. 相似文献
79.
M Tada K Gengyo-Ando T Kobayashi M Fukuyama S Mitani K Kontani T Katada 《Genes to cells : devoted to molecular & cellular mechanisms》2012,17(9):778-789
Ras‐family GTPases regulate a wide variety of cellular functions including cell growth and differentiation. Di‐Ras, which belongs to a distinct subfamily of Ras‐family GTPases, is expressed predominantly in brain, but the role of Di‐Ras in nervous systems remains totally unknown. Here, we report that the Caenorhabditis elegans Di‐Ras homologue drn‐1 is expressed specifically in neuronal cells and involved in synaptic function at neuromuscular junctions. Loss of function of drn‐1 conferred resistance to the acetylcholinesterase inhibitor aldicarb and partially suppressed the aldicarb‐hypersensitive phenotypes of heterotrimeric G‐protein mutants, in which acetylcholine release is up‐regulated. drn‐1 mutants displayed no apparent defects in the axonal distribution of the membrane‐bound second messenger diacylglycerol (DAG), which is a key stimulator of acetylcholine release. Finally, we have identified EPAC‐1, a C. elegans Epac homologue, as a binding partner for DRN‐1. Deletion mutants of epac‐1 displayed an aldicarb‐resistant phenotype as drn‐1 mutants. Genetic analysis of drn‐1 and epac‐1 showed that they acted in the same pathway to control acetylcholine release. Furthermore, DRN‐1 and EPAC‐1 were co‐immunoprecipitated. These findings suggest that DRN‐1 may function cooperatively with EPAC‐1 to modulate synaptic activity in C. elegans. 相似文献
80.
Moriya H Ohbu M Kobayashi N Tanabe S Katada N Futawatari N Sakuramoto S Kikuchi S Okayasu I Watanabe M 《World journal of surgery》2011,35(9):2031-2037