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941.
942.
943.
Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies 总被引:17,自引:0,他引:17
Pereira MA O'Reilly E Augustsson K Fraser GE Goldbourt U Heitmann BL Hallmans G Knekt P Liu S Pietinen P Spiegelman D Stevens J Virtamo J Willett WC Ascherio A 《Archives of internal medicine》2004,164(4):370-376
BACKGROUND: Few epidemiologic studies of dietary fiber intake and risk of coronary heart disease have compared fiber types (cereal, fruit, and vegetable) or included sex-specific results. The purpose of this study was to conduct a pooled analysis of dietary fiber and its subtypes and risk of coronary heart disease. METHODS: We analyzed the original data from 10 prospective cohort studies from the United States and Europe to estimate the association between dietary fiber intake and the risk of coronary heart disease. RESULTS: Over 6 to 10 years of follow-up, 5249 incident total coronary cases and 2011 coronary deaths occurred among 91058 men and 245186 women. After adjustment for demographics, body mass index, and lifestyle factors, each 10-g/d increment of energy-adjusted and measurement error-corrected total dietary fiber was associated with a 14% (relative risk [RR], 0.86; 95% confidence interval [CI], 0.78-0.96) decrease in risk of all coronary events and a 27% (RR, 0.73; 95% CI, 0.61-0.87) decrease in risk of coronary death. For cereal, fruit, and vegetable fiber intake (not error corrected), RRs corresponding to 10-g/d increments were 0.90 (95% CI, 0.77-1.07), 0.84 (95% CI, 0.70-0.99), and 1.00 (95% CI, 0.88-1.13), respectively, for all coronary events and 0.75 (95% CI, 0.63-0.91), 0.70 (95% CI, 0.55-0.89), and 1.00 (95% CI, 0.82-1.23), respectively, for deaths. Results were similar for men and women. CONCLUSION: Consumption of dietary fiber from cereals and fruits is inversely associated with risk of coronary heart disease. 相似文献
944.
Desferioxamine increases iron depletion and apoptosis induced by ara-C of human myeloid leukaemic cells 总被引:4,自引:0,他引:4
Annalisa Leardi Michele Caraglia Carmine Selleri Stefano Pepe Claudia Pizzi Rosario Notaro Antonietta Fabbrocini Sonya De Lorenzo Manuela MusicÒ Alberto Abbruzzese Angelo Raffaele Bianco & Pierosandro Tagliaferri 《British journal of haematology》1998,102(3):746-752
We investigated whether changes in iron metabolism and the transferrin receptor (TRF-R) expression were involved in the antileukaemic effects of arabinoside cytosine (ara-C). Treatment with 100 n M ara-C for 48 h reduced thymidine uptake and increased the surface expression of the TRF-R on leukaemic blasts derived from 13/16 (81%) patients and on the HL-60 and U-937 cell lines. Whereas intracellular non-haem iron was strongly depleted 24 h after ara-C addition, TRF-R up-regulation and recovery of intracellular non-haem iron concentration occurred together after a longer exposure of the cultured cells to the drug. Since iron is an essential regulator of cell proliferation we have evaluated the effects of the combination between ara-C and the iron chelator desferioxamine (DSF) on the growth of HL-60 and U-937 cells. We found that desferioxamine strongly potentiated the effects of ara-C on leukaemic cell growth inhibition and apoptosis. This is the first report of a positive interaction between ara-C and an iron chelator in terms of antileukaemic effects. 相似文献
945.
946.
Alberto Domínguez-Rodríguez Sergio Rodríguez Néstor Baez-Ferrer Pablo Avanzas Pedro Abreu-González Jacobo Silva César Morís Daniel Hernández-Vaquero 《Revista espa?ola de cardiología》2021,74(4):321-328
Introduction and objectivesAsian desert dust has recently been recognized as a trigger for acute myocardial infarction. The inflow of dust from the Sahara into Spain impairs air quality due to an increase in particulate matter concentrations in the ambient air. The aim of the present study was to elucidate whether Saharan dust events are associated with the incidence of acute coronary syndrome (ACS) in patients living near North Africa, the major global dust source.MethodsWe prospectively collected data on hospitalizations due to ACS in 2416 consecutive patients from a tertiary care hospital (Canary Islands, Spain) from December 2012 to December 2017. Concentrations of particulate matter with an aerodynamic diameter 10 microns or smaller (PM10) and reactive gases were measured in the European Air Quality Network implemented in the Canary Islands. We applied the time-stratified case crossover design using conditional Poisson regression models to estimate the impact of PM10 Saharan dust events on the incidence of ACS.ResultsThe occurrence of Saharan dust events observed 0 to 5 days before the onset of ACS was not significantly associated with the incidence of ACS. Incidence rate ratios (IRR) of PM10 levels 1, 2, 3, 4 and 5 days before ACS onset (for changes in 10 μg/m3) were 1.27 (95%CI, 0.87-1.85), 0.92 (95%CI, 0.84-1.01), 0.74 (95%CI, 0.45-1.22), 0.98 (95%CI, 0.87-1.11), and 0.95 (95%CI, 0.84-1.06), respectively.ConclusionsExposure to Saharan desert dust is unlikely to be associated with the incidence of ACS. 相似文献
947.
Paolo De Rai Claudio Franciosi Gian Maria Confalonieri Roberto Biffi Bruno Andreoni Franco Uggeri Alberto Malesci 《Journal of gastrointestinal cancer》1988,3(5):367-373
Summary The effect of somatostatin on the course and severity of experimental pancreatitis was tested. Acute pancreatitis was induced
in 210 Sprague-Dawely rats by injecting a 4.3% sodium taurocholate solution, saturated with trypsin, into a temporarily closed
duodenal loop. Immediately after the end of the surgical procedure somatostatin or, alternatively, normal saline were administered
as a bolus followed by continuous subcutaneous infusion for 9 h. Ninety rats (30 untreated, 30 saline-treated and 30 somatostatin-treated)
were sacrificed 10 h after the induction of pancreatitis to assess the histologic severity of pancreatic lesions, the amount
of peritoneal exudate and the circulating levels of amylase. In another 120 rats (40 untreated, 40 saline-treated and 40 drug-treated)
the mortality rate was evaluated so that the histologic examination of the pancreas followed spontaneous death. In sacrificed
animals somatostatin treatment lowered serum amylase levels and definitely improved pancreatic histopathology (edema, leucocyte
infiltration and necrosis). The drug prevented the occurrence of severe necrosis in all treated animals. Somatostatin did
not affect the mortality rate of pancreatitic rats (70%) although post-mortem histologic examination revealed significantly
less pancreatic histopathology in drug-treated rats than in their controls. 相似文献
948.
Artom A Gandolfo N 《Annali italiani di medicina interna : organo ufficiale della Società italiana di medicina interna》2004,19(1):50-53
We report a case of benign idiopathic retroperitoneal fibrosis in a 39-year-old male, who was successfully treated with immunosuppressive drugs only. Advances in imaging techniques, especially in magnetic resonance imaging, often permit an accurate diagnosis in retroperitoneal fibrosis, avoiding open biopsy or biopsy by means of image-guided techniques. In addition, the modern medical approach with immunosuppressive drugs is based on evidence of disease regression following the medical therapy and is frequently effective. Hence, it is possible to avoid conventional surgery or laparoscopy. In the present case the response to immunosuppressive treatment was objectively assessed by means of enhanced computed tomography, magnetic resonance and nuclear medicine (Ga-67), showing an important decrease in the extent of the disease at follow-up. Our case shows the important role of the specialist in Internal Medicine in the treatment of this uncommon connective tissue disease. 相似文献
949.
Alcibar J Cabrera A Peña N Baraldi C Arriola J Aramendi J 《Revista espa?ola de cardiología》2003,56(8):822-825
Transcatheter valvulotomy in pulmonary atresia with an intact ventricular septum can be used as a first step to create biventricular circulation and to stimulate further development of the hypoplastic right ventricle. We describe our experience in a case of a neonate with this congenital cardiac defect who underwent successful transcatheter perforation of the atretic pulmonary valve. This report highlights the utility of a special technique based on the use of a gooseneck snare positioned just above the atretic valve to guide the advance of a coronary guidewire. Other therapeutic alternatives are considered. 相似文献
950.
José Alberto de Agustín José Juan Gómez de Diego Pedro Marcos-Alberca Patricia Mahía José Luis Rodrigo María Luaces Iván Javier Núñez-Gil Joaquín Ferreiros Ana Bustos Beatriz Cabeza Miguel Ángel García-Fernández Carlos Macaya Leopoldo Pérez de Isla 《Revista espa?ola de cardiología》2018,71(2):105-109