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Muammer Melih AHN Eray UZUNOLU Mücahit YALIN Gken CESUR Mehmet YILDIZ Pnar AYSERT YILDIZ Hasan Seluk
ZGER Süleyman CEBEC Recep KARAMERT Mehmet DÜZLÜ Hakan TUTAR Murat DZBAY Alper CEYLAN 《Turkish Journal of Medical Sciences》2021,51(5):2296
Background/aimThis study aims to evaluate of olfactory and gustatory functions of COVID-19 patients and possible risk factors for olfactory and gustatory dysfunctions. Materials and methodsThe cross-sectional study included adult patients who were diagnosed with COVID-19 in Gazi University Hospital between April 2020 and June 2020. Volunteered patients participated in a survey in which olfactory and gustatory functions and various clinical information were questioned. Sinonasal Outcome Test-22 was also administrated to all patients.ResultsA hundred and seventy-one patients participated in this study. Olfactory and gustatory dysfunctions rates were 10.5% (n: 18) and 10.5% (n: 18), respectively. Patients without any symptom other than smell and taste dysfunctions were clustered as group 1 and patients who are clinically symptomatic were clustered as group 2. Olfactory dysfunction occurred in 8% of group 1 and 17.4% of group 2 (p = 0.072). Gustatory dysfunction rate of smokers was 19.7% and significantly higher than gustatory dysfunction rate of nonsmokers (5.5%) (p = 0.007). Twenty-seven-point-eight percent of the patients with olfactory dysfunction (n = 5) were male and 72.2% (n: 13) were female. Sex did not show significant effect on rate of olfactory dysfunction. Twenty-five patients participated in psychophysical olfactory function test. No participant reported olfactory dysfunction at the time of test. Of the participants, 64% (n: 16) were normosmic and 36% (n: 9) were hyposmic according to Sniffin’ Stick test. ConclusionOlfactory and gustatory dysfunctions are more common in patients who are clinically symptomatic than those diagnosed during contact tracing. Objective tests may show that frequency of olfactory dysfunction is greater than frequency of self-reported olfactory dysfunction. 相似文献
95.
Ahmet YOZGAT Benan KASAPOLU Güray CAN Alpaslan TANOLU Yusuf Serdar SAKN Kadir Serkan YALIN Müjgan GÜRLER Mustafa KAPLAN Mehmet Gktürk KABAN Mehmet KIRSOY Umut KARA Murat KEKLL 《Turkish Journal of Medical Sciences》2021,51(4):1675
Background and aimThe aim of this study is to evaluate whether the long-term (≥4 weeks) use of proton pump inhibitors (PPIs) is a risk factor for intubation requirement and mortality in patients hospitalized for COVID-19.Materials and methods In this multicentric retrospective study, a total of 382 adult patients (≥18 years of age) with confirmed COVID-19 who were hospitalized for treatment were enrolled. The patients were divided into two groups according to the periods during which they used PPIs: the first group included patients who were not on PPI treatment, and the second group included those who have used PPIs for more than 4 weeksResultsThe study participants were grouped according to their PPI usage history over the last 6 months. In total, 291 patients did not use any type of PPI over the last 6 months, and 91 patients used PPIs for more than 4 weeks. Older age (HR: 1.047, 95% CI: 1.026–1.068), current smoking (HR: 2.590, 95% CI: 1.334–5.025), and PPI therapy for more than 4 weeks (HR: 1.83, 95% CI: 1.06–2.41) were found to be independent risk factors for mortalityConclusionThe results obtained in this study show that using PPIs for more than 4 weeks is associated with negative outcomes for patients with COVID-19. Patients receiving PPI therapy should be evaluated more carefully if they are hospitalized for COVID-19 treatment. 相似文献
96.
Factor P Akhmedov AT McDonald JD Qu A Wu J Jiang H Dasgupta T Panettieri RA Perera F Miller RL 《American journal of respiratory cell and molecular biology》2011,45(5):1045-1049
Incomplete combustion produces a pollutant mixture that includes polycyclic aromatic hydrocarbons (PAHs). Previous work by the Columbia Center for Children's Environmental Health (CCCEH) and others linked exposure to PAH with symptoms of asthma and other adverse health effects in young children. Inhaled β(2)-adrenergic agonists are mainstays in the treatment of reactive airway diseases. These exogenous catecholamines engage membrane-bound β(2)-adrenergic receptors (β(2)AR) on airway epithelial and smooth muscle cells to cause airway dilation. We hypothesized that exposure to PAH might similarly interfere with the function of β(2)AR in airway epithelial or smooth muscle cells, reducing the efficacy of a medication important for the treatment of asthma symptoms. A PAH mixture was devised, based on ambient levels measured prenatally among a cohort of pregnant women participating at the CCCEH. Primary airway epithelial and smooth muscle cells were exposed to varying concentrations of the PAH mixture, and expression, function, and signaling of β(2)AR were assessed. Murine tracheal epithelial cells and human airway smooth muscle cells, after exposure to a PAH mixture, exhibited reduced expression and function of β(2)AR. These findings support our hypothesis that environmentally relevant PAHs can impede β(2)AR-mediated airway relaxation, and suggest a new paradigm where air pollutants not only contribute to the pathogenesis of childhood asthma, but also diminish responsiveness to standard therapy. 相似文献
97.
Egorova MV Rogovskaya YV Ivanov AV Andreev SL Akhmedov ShD Afanas'ev SA 《Bulletin of experimental biology and medicine》2011,150(4):543-546
We performed a comparative study of the localization, distribution, metabolic activity, and surface properties of human bone
marrow mesenchymal stromal cells after static and perfusion seeding to macroporous alginate cryogels. A simple perfusion system
for mesenchymal stromal cell seeding to macroporous alginate cryogel sponges proposed in this study resulted in rapid and
uniform distribution of cells within the whole volume of the scaffold preserving functional and morphological properties of
the cells. 相似文献
98.
测试磁驱动轴流心室辅助装置主体血泵溶血性能。利用计算流体力学(CFD)软件ANSYS,基于红细胞受到切应力和相应曝光时间的计算溶血方法预测血泵溶血性能,计算红细胞粒子随着时间推移在血泵内运动轨迹上受到破坏程度。通过体外模拟循环实验实际测试血泵体外溶血性能,计算得到血泵实际标准溶血指数。CFD计算结果转化的标准溶血指数与实际体外实验结果比较相差较大,与CFD计算简化和实际计算循环周期有很大关系。磁驱动轴流心室辅助装置主体血泵有较好的实际溶血性能,血泵实验期间无不良状况发生,可以进行进一步实验。 相似文献
99.
SUBIN PARK MAENG JE CHO SUNG MAN CHANG JAE NAM BAE HONG JIN JEON SEONG‐JIN CHO BYUNG‐SOO KIM IN‐WON CHUNG JOON HO AHN HAE WOO LEE JIN PYO HONG 《Journal of sleep research》2010,19(4):567-577
The aim of this study is to examine relationships of sleep duration with sociodemographic and health‐related factors, psychiatric disorders and sleep disturbances in a nationwide sample in Korea. A total of 6510 subjects aged 18–64 years participated in this study. Logistic regression was used to calculate the odd ratios and 95% confidence intervals of the covariates, psychiatric disorders and sleep disturbances across the following sleep duration categories: 5 h or less, 6, 7, 8 and 9 h or more per day. Low levels of education, unemployment and physical illness were associated with sleeping for 5 h or less and 9 h or more. Being older and widowed/divorced/separated, high levels of physical activity, pain/discomfort, obesity and high scores on the General Health Questionnaires were associated with sleeping for 5 h or less. Female, being younger and underweight were associated with sleeping for 9 h or more. Alcohol dependence, anxiety disorder and social phobia were associated significantly with sleeping for 5 h or less and 9 h or more. Other psychiatric disorders were more common in subjects who slept for 5 h or less (e.g. alcohol use disorder, mood disorder, major depressive disorder, dysthymic disorder, obsessive‐compulsive disorder and specific phobia) or 9 h or more (e.g. post‐traumatic stress disorder). In addition, subjects who slept for 5 h or less reported more sleep disturbances than did subjects who slept for 7 h. Short or long sleep is associated with psychiatric disorders and/or sleep disturbance, therefore attention to the mental health of short or long sleepers is needed. 相似文献
100.
ENAMEL MATRIX DERIVATIVE FOR PERIODONTAL TISSUE REGENERATION IN INTRABONY DEFECTS . In: THE COCHRANE DATABASE OF SYSTEMATIC REVIEWS ISSUE . 《Journal of Evidence》2005,5(4):234-236
ENAMEL MATRIX DERIVATIVE (EMDOGAIN®) FOR PERIODONTAL TISSUE REGENERATION IN INTRABONY DEFECTS (Cochrane Review). In: THE COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSUE 4, 2005.Esposito M, Grusovin MG, Coulthard P, Worthington H