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排序方式: 共有1076条查询结果,搜索用时 15 毫秒
91.
Gloria Maccabelli MD Anna Pichiecchio MD Andrea Guala MD Michela Ponzio PhD Fulvia Palesi PhD Diego Maranzana RT Guy Umberto Poloni PhD Stefano Bastianello MD PhD Cesare Danesino MD PhD 《Movement disorders》2010,25(15):2670-2674
No brain abnormalities are usually detected on conventional magnetic resonance imaging (MRI) in benign hereditary chorea (BHC); there are currently no studies with advanced techniques in literature. We investigated whether conventional and advanced MRI techniques could depict regional brain abnormalities in two familial BHC patients and 24 healthy controls. No brain abnormalities on conventional scans were detectable; also, no significant differences in fractional anisotropy of the basal nuclei were observed. Volumetric analysis showed a decreased volume of the striatum bilaterally compared with controls, whereas spectroscopy demonstrated a significant increased myoinositol/creatine ratio bilaterally, a reduction of choline/creatine ratio bilaterally, and of N‐acetyl‐aspartate/creatine in the right putamen. With the limits of the small sample size in the patient group, these data show that, despite the absence of macroscopic changes on conventional MRI, volumetric and metabolic abnormalities are present in the basal nuclei of BHC patients. © 2010 Movement Disorder Society. 相似文献
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93.
Tilford JM Aitken ME Goodman AC Fiser DH Killingsworth JB Green JW Adelson PD 《Neurocritical care》2007,7(1):64-75
Background
Cost-effectiveness analysis relies on preference-weighted health outcome measures as they form the basis for quality adjusted life years. Studies of preference-weighted outcomes for children following traumatic brain injury are lacking. 相似文献94.
95.
Monteiro MC Lima HC Souza AA Titus RG Romão PR Cunha FQ 《The American journal of tropical medicine and hygiene》2007,76(1):88-94
The mechanism by which the salivary gland lysate (SGL) of Lutzomyia longipalpis enables Leishmania infection remains under investigation. One possibility is that saliva promotes cellular recruitment leading to development of skin lesions. In this study, we investigated leukocyte recruitment induced by L. major, L. major + SGL, or SGL alone into the peritoneal cavity of BALB/c mice. The administration of L. major with or without SGL induced neutrophil migration six hours after infection. Interestingly, after seven days, the BALB/c mice still had eosinophils and mononuclear cells in their peritoneal cavities. Flow cytometric analysis showed an increase in the CD4(+) CD45RB(low) T cell subset (effector or memory cells) compared with the CD4(+) CD45RB(high) subset (naive cells). Moreover, the co-injection of L. major with SGL enhanced production of interleukin-10. These results suggest that SGL can facilitate Leishmania infection by modulating leukocyte recruitment and Th2 cytokine production at the inflammatory focus. 相似文献
96.
Kai Tonda MD Yu Iwabuchi MD Tohru Shiga MD Yoshiki Owaki RT Arashi Fujita RT Takehiro Nakahara MD Ryosuke Sakurai MD Atsushi Shimizu MD Yoshitake Yamada MD Masahiro Okada MD Masahiro Jinzaki MD 《Diabetes, obesity & metabolism》2023,25(12):3521-3528
Aims
To assess the impact of various patient characteristics on the dynamics of liver glucose metabolism using automated multiparametric imaging with whole-body dynamic 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET).Materials and Methods
We retrospectively enrolled 540 patients who underwent whole-body dynamic FDG-PET. Three quantitative indices representing hepatic glucose metabolism [mean standardized uptake value normalized by lean body mass (SULmean), metabolic glucose rate (kinetic index) and distribution volume (DV)] were measured from multiparametric PET images produced automatically based on the Patlak plot model. Patient characteristics including age, sex, body mass index, fasting time, blood glucose level, and the presence of diabetes mellitus (DM) or hepatic steatosis (HS) were collected. We examined the correlations between the characteristic factors and three quantitative indices using multiple regression analysis.Results
The success rate of kinetic analysis using multiparametric PET imaging was 93.3% (504/540). Hepatic SULmean was significantly correlated with age (p < .001), sex (p < .001) and blood glucose level (p = .002). DV was significantly correlated with age (p = .033), sex (p < .001), body mass index (p = .002), fasting time (p = .043) and the presence of HS (p = .002). The kinetic index was significantly correlated with age (p < .001) and sex (p = .004). In the comparison of the healthy, DM and HS groups, patients with DM had a significantly increased SULmean, whereas patients with HS had a significantly decreased DV.Conclusions
Our results showed that liver glucose metabolism was influenced by various patient characteristic factors. Multiparametric FDG-PET imaging can be used to analyse the kinetics of liver glucose metabolism in routine clinical practice. 相似文献97.
Giulia Ghizzoni MD Marco B. Ancona MD Vittorio Romano RT Barbara Bellini MD Luca Ferri MD Filippo Russo MD Ciro Vella MD Domitilla Gentile MD Giulia Chionchio MD Veronica Macelletti MD Francesco Ancona MD Eustachio Agricola MD Anna Palmisano MD Antonio Esposito MD Matteo Montorfano MD 《Catheterization and cardiovascular interventions》2023,102(3):538-541
98.
99.
William L. Smith Spencer R. Hedges Eli Mordechai Martin E. Adelson Jason P. Trama Scott E. Gygax Andrew M. Kaunitz David W. Hilbert 《Journal of clinical microbiology》2014,52(8):3078-3081
Matched vaginal and cervical specimens from 96 subjects were analyzed by quantitative PCR for the presence and concentration of bacterial vaginosis-associated microbes and commensal Lactobacillus spp. Detection of these microbes was 92% concordant, indicating that microbial floras at these body sites are generally similar. 相似文献
100.
Fernando Tobias Silveira Ralph Lainson Adelson Alcimar Almeida De Souza Marliane Batista Campos Liliane Almeida Carneiro Luciana Vieira Rego Lima Patrícia Karla Santos Ramos Cláudia Maria de Castro Gomes Marcia Dalastra Laurenti Carlos Eduardo Pereira Corbett 《Parasitology research》2010,106(2):377-386
This was a prospective study carried out during a period over 2 years (May/2006–September/2008) with a cohort of 1,099 individuals of both genders, aged 1 year old and older, from an endemic area of American visceral leishmaniasis (AVL) in Pará state, Brazil. The object was to analyze the prevalence and incidence of human Leishmania (L.) infantum chagasi infection as well as the dynamics evolution of its clinical-immunological profiles prior identified: (1) asymptomatic infection (AI); (2) symptomatic infection (SI = AVL); (3) sub-clinical oligosymptomatic infection (SOI); (4) sub-clinical resistant infection (SRI) and; (5) indeterminate initial infection (III). The infection diagnosis was performed by using both the indirect fluorescent antibody test and leishmanin skin test with amastigotes and promastigotes antigens of L. (L.) i. chagasi, respectively. A total of 187 cases of infection were recorded in the prevalence (17%), 117 in the final incidence (6.9%), and 304 in the accumulated prevalence (26.7%), which provided the following distribution into the clinical-immunological profiles: AI, 51.6%; III, 22.4%; SRI, 20.1%; SOI, 4.3%; and SI (=AVL), 1.6%. The major finding regarding the dynamics evolution of infection was concerned to III profile, from which the cases of infection evolved to either the resistant profiles, SRI (21 cases, 30.8%) and AI (30 cases, 44.1%), or the susceptible SI (=AVL; 1 case, 1.5%); the latter 16 cases remained as III till the end of the study. These results provided the conclusion that this diagnostic approach may be useful for monitoring human L. (L.) i. chagasi infection in endemic area and preventing the high morbidity of severe AVL cases. 相似文献