全文获取类型
收费全文 | 413篇 |
免费 | 24篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 38篇 |
妇产科学 | 6篇 |
基础医学 | 56篇 |
口腔科学 | 8篇 |
临床医学 | 45篇 |
内科学 | 67篇 |
皮肤病学 | 18篇 |
神经病学 | 12篇 |
特种医学 | 43篇 |
外科学 | 35篇 |
综合类 | 35篇 |
预防医学 | 19篇 |
眼科学 | 2篇 |
药学 | 23篇 |
肿瘤学 | 26篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 6篇 |
2018年 | 5篇 |
2017年 | 7篇 |
2016年 | 10篇 |
2015年 | 8篇 |
2014年 | 12篇 |
2013年 | 16篇 |
2012年 | 10篇 |
2011年 | 12篇 |
2010年 | 19篇 |
2009年 | 23篇 |
2008年 | 15篇 |
2007年 | 16篇 |
2006年 | 13篇 |
2005年 | 14篇 |
2004年 | 5篇 |
2003年 | 6篇 |
2002年 | 8篇 |
2001年 | 11篇 |
2000年 | 9篇 |
1999年 | 19篇 |
1998年 | 37篇 |
1997年 | 29篇 |
1996年 | 14篇 |
1995年 | 14篇 |
1994年 | 16篇 |
1993年 | 13篇 |
1992年 | 5篇 |
1991年 | 7篇 |
1990年 | 3篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 12篇 |
1984年 | 2篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 5篇 |
1978年 | 1篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1955年 | 1篇 |
排序方式: 共有452条查询结果,搜索用时 281 毫秒
101.
JENS HENRICHS JACQUELINE J SCHENK CHARLOTTE S BARENDREGT HENK G SCHMIDT ERIC AP STEEGERS ALBERT HOFMAN VINCENT WV JADDOE HENRIETTE A MOLL FRANK C VERHULST HENNING TIEMEIER 《Developmental medicine and child neurology》2010,52(7):644-651
Aim The aim of this study was to investigate within a population‐based cohort of 4384 infants (2182 males, 2202 females) whether fetal growth from early pregnancy onwards is related to infant development and whether this potential relationship is independent of postnatal growth. Method Ultrasound measurements were performed in early, mid‐, and late pregnancy. Estimated fetal weight was calculated using head and abdominal circumference and femur length. Infant development was measured with the Minnesota Infant Development Inventory at 12 months (SD 1.1mo, range 10–17mo). Information on postnatal head size and body weight at 7 months was obtained from medical records. Results After adjusting for potential confounders and for postnatal growth, faster fetal weight gain from mid‐ to late pregnancy predicted a reduced risk of delayed social development (odds ratio [OR] 0.82; 95% confidence interval [CI] 0.71–0.95, p=0.008), self‐help abilities (OR 0.84; 95% CI 0.73–0.98, p=0.023), and overall infant development (OR 0.65; 95% CI 0.49–0.87, p=0.003). Similar findings were observed for fetal head growth from mid‐ to late pregnancy. Interpretation Faster fetal growth predicts a lower risk of delayed infant development independent of postnatal growth. These results suggest that reduced fetal growth between mid‐ and late pregnancy may determine subsequent developmental outcomes. 相似文献
102.
A 22-year-old male patient underwent a segmental resection of the ileum due to clinical symptoms of bowel obstruction and radiological evidence of ileal wall thickening and enlarged mesenteric nodes. Histopathological examination of the resected specimen revealed an extranodal marginal zone B-cell lymphoma(MALToma) of the intestine and tuberculous lesions along with a solitary Peutz-Jeghers polyp. The case is presented for its rarity and to stress upon the clinical and radiological challenges that arise when lymphomas and tuberculous lesions co-exist at the same site.KEY WORDS: Intestinal lymphoma, MALToma, marginal zone lymphoma, Peutz-Jeghers polyp, tuberculosis 相似文献
103.
Acute thrombotic and hemorrhagic manifestations of thrombocytosis associated with myeloproliferative disorders may be life threatening. Conventional therapy with radioisotopes and/or cytotoxic drugs may require weeks for effective control of platelet counts. In five patients, plateletpheresis by discontinuous-flow (Haemonetics) or continuous-flow (Aminco Celltrifuge) centrifugation was used as a means of reducing platelet counts acutely. With each procedure, approximately 2-9 X 10(12) platelets were removed, resulting in decrements in platelet counts and relief of symptoms. Plateletpheresis is a useful and safe acute means of controlling platelet counts in myeloproliferative disorders. 相似文献
104.
Clinical Features,Familial History,and Migraine Precursors in Patients With Definite Vestibular Migraine: The VM‐Phenotypes Projects 下载免费PDF全文
Roberto Teggi MD Bruno Colombo MD Roberto Albera MD Giacinto Asprella Libonati MD Cristiano Balzanelli MD Angel Batuecas Caletrio MD PhD Augusto Casani MD Juan Manuel Espinoza‐Sanchez MD Paolo Gamba MD Jose A. Lopez‐Escamez MD; PhD Sergio Lucisano MD Marco Mandalà MD Giampiero Neri MD Daniele Nuti MD Rudy Pecci MD Antonio Russo MD Eduardo Martin‐Sanz MD PhD Ricardo Sanz MD PhD Gioacchino Tedeschi MD Paola Torelli MD Paolo Vannucchi MD Giancarlo Comi MD PhD Mario Bussi MD 《Headache》2018,58(4):534-544
105.
Alistair AP Slesser Sufian Sultan Faris Kubba David P Sellu 《World journal of emergency surgery : WJES》2010,5(1):27
Background
Endometriosis is a benign condition affecting females of reproductive age. Although intestinal endometriosis is common it is rare for the condition to manifest as an acute bowel obstruction secondary to ileocaecal and appendicular endometriosis. This case is important to report as it highlights the diagnostic difficulty this particular condition presents to an emergency surgeon. 相似文献106.
Background and purpose:
Migraine is a disabling neurological disorder involving activation, or the perception of activation, of trigeminovascular afferents containing calcitonin gene-related peptide (CGRP). Released CGRP from peripheral trigeminal afferents causes dilatation of dural blood vessel, and this is used to measure trigeminal nerve activation. Kainate receptors with the GluR5 subunit (iGluR5, ionotropic glutamate receptor) are present in the trigeminal ganglion and may be involved in nociception. We investigated the possible involvement of prejunctional iGluR5 kainate receptors on CGRP release from trigeminal afferents.Experimental approach:
We used neurogenic dural vasodilatation, which involves reproducible vasodilatation in response to CGRP release after electrical stimulation of the dura mater surrounding the middle meningeal artery. The effects of the specific iGluR5 receptor antagonist UBP 302 and agonist (S)-(-)-5-iodowillardiine were investigated on neurogenic and CGRP-induced dural vasodilatation in rats, by using intravital microscopy.Key results:
Administration of 10 and 20 mg·kg−1 of iodowillardiine inhibited electrically induced dural vessel dilatation, an effect blocked by pretreatment with 50 mg·kg−1 UBP 302. Administration of the iGluR5 receptor antagonist UBP 302 alone had no significant effect. CGRP (1 mg·kg−1)-induced dural vasodilatation was not inhibited by the iGluR5 receptor agonist iodowillardiine.Conclusions and implications:
This study demonstrates that activation of the iGluR5 kainate receptors with the selective agonist iodowillardiine is able to inhibit neurogenic dural vasodilatation probably by inhibition of prejunctional release of CGRP from trigeminal afferents. Taken together with recent clinical studies the data reinforce CGRP mechanisms in primary headaches and demonstrate a novel role for kainate receptor modulation of trigeminovascular activation. 相似文献107.
AP Schmidt AE B?hmer C Antunes C Schallenberger LO Porciúncula E Elisabetsky DR Lara DO Souza 《British journal of pharmacology》2009,156(1):163-172
Background and purpose
Allopurinol is a potent inhibitor of the enzyme xanthine oxidase, used primarily in the treatment of hyperuricemia and gout. It is well known that purines exert multiple effects on pain transmission. We hypothesized that the inhibition of xanthine oxidase by allopurinol, thereby reducing purine degradation, could be a valid strategy to enhance purinergic activity. The aim of this study was to investigate the anti-nociceptive profile of allopurinol on chemical and thermal pain models in mice.Experimental approach
Mice received an intraperitoneal (i.p.) injection of vehicle (Tween 10%) or allopurinol (10–400 mg kg−1). Anti-nociceptive effects were measured with intraplantar capsaicin, intraplantar glutamate, tail-flick or hot-plate tests.Key results
Allopurinol presented dose-dependent anti-nociceptive effects in all models. The opioid antagonist naloxone did not affect these anti-nociceptive effects. The non-selective adenosine-receptor antagonist caffeine and the selective A1 adenosine-receptor antagonist, DPCPX, but not the selective A2A adenosine-receptor antagonist, , completely prevented allopurinol-induced anti-nociception. No obvious motor deficits were produced by allopurinol, at doses up to 200 mg kg−1. Allopurinol also caused an increase in cerebrospinal fluid levels of purines, including the nucleosides adenosine and guanosine, and decreased cerebrospinal fluid concentration of uric acid. SCH58261Conclusions and implications
Allopurinol-induced anti-nociception may be related to adenosine accumulation. Allopurinol is an old and extensively used compound and seems to be well tolerated with no obvious central nervous system toxic effects at high doses. This drug may be useful to treat pain syndromes in humans. 相似文献108.
ANNEMARIE M VISSER VINCENT WV JADDOE LIDIA R ARENDS HENNING TIEMEIER ALBERT HOFMAN HENRIETTE A MOLL ERIC AP STEEGERS MONIQUE MB BRETELER WILLEM FM ARTS 《Developmental medicine and child neurology》2010,52(11):1014-1020
Aim To examine the incidence of paroxysmal epileptic and non‐epileptic disorders and the associated prenatal and perinatal factors that might predict them in the first year of life in a population‐based cohort. Method This study was embedded in the Generation R Study, a population‐based prospective cohort study from early fetal life onwards. Information about the occurrence of paroxysmal events, defined as suddenly occurring episodes with an altered consciousness, altered behaviour, involuntary movements, altered muscle tone, and/or a changed breathing pattern, was collected by questionnaires at the ages of 2, 6, and 12 months. Information on possible prenatal and perinatal determinants was obtained by measurements and questionnaires during pregnancy and after birth. Results Information about paroxysmal events in the first year of life was available in 2860 participants (1410 males, 1450 females). We found an incidence of paroxysmal disorders of 8.9% (n=255) in the first year of life. Of these participants, 17 were diagnosed with febrile seizures and two with epilepsy. Non‐epileptic events included physiological events, apnoeic spells, loss of consciousness by causes other than epileptic seizures or apnoeic spells, parasomnias, and other events. Preterm birth (p<0.001) and low Apgar score at 1 minute (p<0.05) were significantly associated with paroxysmal disorders in the first year of life. Continued maternal smoking during pregnancy and preterm birth were significantly associated with febrile seizures in the first year of life (p<0.05). Interpretation Paroxysmal disorders are frequent in infancy. They are associated with preterm birth and a low Apgar score. Epileptic seizures only form a minority of the paroxysmal events in infancy. In this study, children whose mothers continued smoking during pregnancy had a higher reported incidence of febrile seizures in the first year of life. These findings may generate various hypotheses for further investigations. 相似文献
109.
110.