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41.
E.-K. YIM S.B. LEE K.-H. LEE C.-J. KIM† & J.-S. PARK† 《International journal of gynecological cancer》2006,16(3):1321-1329
5-Fluorouracil (5-FU) is currently being used as an anticancer drug to reduce tumor bulk in order to increase the operability rate and postoperative survival in patients with cervical cancer, which has been combined with cisplatin (CP) because of its superior activities observed in human carcinoma cells. However, the combined anticancer effect of 5-FU and CP in cervical carcinoma cells is poorly understood. Therefore, we conducted a study to investigate whether anticancer drugs 5-FU and CP may exhibit the combined antiproliferative effect in cervical carcinoma cells. Using proteomics analysis, including two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS), we investigated the antiproliferative effect-related proteins after treatment with 5-FU and/or CP. Our experiments showed that the combination of 5-FU and CP engaged both the apoptotic pathways: the membrane death receptor-mediated apoptosis pathway and the mitochondrial apoptotic pathway. Moreover, the combination of 5-FU and CP resulted in remarkable increasing susceptibility to apoptosis. We suggest that the combination of 5-FU and CP suppresses the growth of cervical carcinoma cells by synergistic effect with the induction of apoptosis. In vitro synergistic effect of 5-FU and CP supports the basis of the clinical application of the combination chemotherapy to the patients with cervical cancer. 相似文献
42.
S.-H. SONG J.-K. LEE M.-J. OH J.-Y. HUR Y.-K. PARK & H.-S. SAW 《International journal of gynecological cancer》2006,16(4):1608-1613
To identify the factors that may predict the progression or persistence of untreated mild dysplasia of the uterine cervix, we performed a retrospective review of 118 patients with histologically verified mild dysplasia who underwent colposcopic biopsies between January 1999 and December 2003. Regression to normal occurred in 70.3%, progression to moderate dysplasia or worse occurred in 11.0%, and persistence of mild dysplasia occurred in 18.7%. In regression/progression analysis, progression of untreated mild dysplasia was 34.5% (10/29) in patients with high viral loads (> or =100 relative light units/positive control [RLU/PC]) and 4.5% (3/67) in those with low viral loads (1 to <100 RLU/PC) and negative human papillomavirus (HPV) tests (P < 0.001). Women with high viral loads had a 13-fold greater chance of progression of untreated mild dysplasia than those with low viral loads and negative HPV tests (CI: 2.494-95.297; P = 0.0022). Those associated with both positive smear and positive HPV test (12/45 = 26.7%) were at a greater risk of progression of untreated mild dysplasia as compared with those with positive smear and negative HPV (0/17 = 0.0%) or those with negative smear and positive HPV test (1/18 = 5.6%). Those with high viral loads and both with positive smear and positive HPV test should be followed closely because of their increased risk of progression of untreated mild dysplasia. 相似文献
43.
Lee YW Kang IH Kim SM Lee HL Koo TW Lee HS Hwang JJ 《International journal of legal medicine》2000,114(1-2):118-121
The hypervariable short tandem repeat (STR) locus D12S391 was investigated in a Korean population and 34 fragments were sequenced
to confirm the structure of alleles. From these sequenced fragments an allelic ladder containing 13 sequenced alleles was
constructed. From 595 unrelated Koreans, 14 alleles were detected and one variant allele 19.3 was observed. The observed heterozygosity
was 0.795 and no deviation from Hardy-Weinberg equilibrium was observed in the Korean population (p = 0.606). The allele frequency distribution in the Korean population was not similar to other racial or ethnic groups except
for Egyptians, Yemenis, Japanese and Caucasoids from the Rhine area. No mutations were observed in the 702 meioses from 144
Korean families. This study demonstrates that the STR locus D12S391 is a useful tool for forensic identification and parentage
testing.
Received: 15 September 1999 / Accepted: 18 December 1999 相似文献
44.
Alveolar soft part sarcoma: MR and angiographic findings 总被引:5,自引:5,他引:0
Suh JS Cho J Lee SH Shin KH Yang WI Lee JH Cho JH Suh KJ Lee YJ Ryu KN 《Skeletal radiology》2000,29(12):680-689
Objective. To present the MR and angiographic findings of alveolar soft part sarcoma (ASPS).
Design and patients. MR examinations (12 tumors of 10 patients) of ASPS performed at multiple hospitals were retrospectively reviewed. The tumors
were found in the thigh (n=4), lower leg (n=4), femur (n=2, local metastasis), scalp (n=1) and arm (n=1). The MR signal characteristics including signal intensity, homogeneity and signal void of lesions and bony invasion including
direct invasion or local metastasis were evaluated. Angiographic findings (n=4) and post-embolotherapy follow-up MR imaging (n=2) findings were also assessed.
Results. Local bony metastasis was found in two cases. Seven tumors showed heterogeneous high signal intensity on T1- and T2-weighted
images with good enhancement. One tumor had a very high signal on T1-weighted images. Eight tumors (67%) showed numerous signal
voids in or near the tumors. All four angiographic studies showed numerous enlarged vessels, arteriovenous shunts and delayed
washout. Two cases mimicked arteriovenous malformations on angiographic studies but MR images demonstrated solid soft tissue
components as well as tortuous vessels.
Conclusions. High signal on T1-weighted image and numerous signal voids are highly suggestive of ASPS, although they are not universal
as has been suggested and arteriovenous malformation should be included in the differential diagnosis. Local bony metastases
in ASPS were seen in two cases and should be carefully investigated.
Received: 12 April 2000 Revision requested: 27 June 2000, 8 August 2000 Revision received: 2 August 2000, 21 August 2000 Accepted:
22 August 2000 相似文献
45.
Frequently, pathological changes of the pancreas initially show unspecific symptoms. Endoscopic ultrasound represents an indispensable method to reliably distinguish the different forms of pancreatic diseases. New methods in image processing, e.g. contrast-enhanced endoscopic ultrasound, real-time elastography and 3D reconstruction may enlarge the spectrum of diagnostic possibilities and increase the reliability of differentiating pathologic changes of the pancreas by endoscopic ultrasound. 相似文献
46.
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48.
An overview on children's wheelchair positioning in France. A French team working in a special center has made a clinical approach and gives their conclusions. 相似文献
49.
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