排序方式: 共有74条查询结果,搜索用时 0 毫秒
71.
72.
复发性多软骨炎(relapsing polychondritis)是一种原因不明、多部位软骨反复发生的炎性反应疾病.其受累软骨部位不同,临床表现多样,易误诊[1-4].如呼吸道软骨受累可导致呼吸困难,往往预后较差.本文报道1例复发性多软骨炎累及呼吸道,出现呼吸困难,并导致困难气管切开术的病例. 相似文献
73.
Th2 cytokines play a pivotal role in the pathogenesis of allergic rhinitis. To investigate the effect of p38 mitogen-activated protein kinase (MAPK) on the production of Th2 cytokines such as IL-4 and IL-5 in allergic rhinitis, a model of allergic rhinitis was established in SD rats. The expression level of p38 MAPK mRNA in PBMCs was detected by means of real time quantitative RT-PCR. The p38 MAPK activity in PBMCs was detected by Western blotting. PBMCs were cultured with various concentrations of p38 MAPK inhibitor SB 239063 or without the treatment, and then IL-4, IL-5 levels of the supernatant were determined by using sandwich ELISA. The results showed that mRNA expression and activity of p38 MAPK in PBMCs were significantly higher in allergic rhinitis rats than in control rats (P〈0.05). The p38 MAPK inhibitor SB 239063 decreased the production of IL-4 and IL-5 in a dose-dependent manner. It is concluded that p38 MAPK plays an important role in the pathogenesis of allergic rhinitis which is associated with Th2 cytokines release. 相似文献
74.
复发性多软骨炎(relapsing polychondritis)是一种原因不明、多部位软骨反复发生的炎性反应疾病.其受累软骨部位不同,临床表现多样,易误诊[1-4].如呼吸道软骨受累可导致呼吸困难,往往预后较差.本文报道1例复发性多软骨炎累及呼吸道,出现呼吸困难,并导致困难气管切开术的病例. 相似文献