全文获取类型
收费全文 | 24126篇 |
免费 | 1250篇 |
国内免费 | 51篇 |
专业分类
耳鼻咽喉 | 533篇 |
儿科学 | 1119篇 |
妇产科学 | 1009篇 |
基础医学 | 2957篇 |
口腔科学 | 754篇 |
临床医学 | 1713篇 |
内科学 | 5376篇 |
皮肤病学 | 461篇 |
神经病学 | 1881篇 |
特种医学 | 934篇 |
外科学 | 3714篇 |
综合类 | 127篇 |
一般理论 | 5篇 |
预防医学 | 1525篇 |
眼科学 | 707篇 |
药学 | 1692篇 |
中国医学 | 48篇 |
肿瘤学 | 872篇 |
出版年
2023年 | 277篇 |
2022年 | 335篇 |
2021年 | 668篇 |
2020年 | 420篇 |
2019年 | 484篇 |
2018年 | 873篇 |
2017年 | 711篇 |
2016年 | 880篇 |
2015年 | 774篇 |
2014年 | 1103篇 |
2013年 | 1397篇 |
2012年 | 1511篇 |
2011年 | 1590篇 |
2010年 | 1039篇 |
2009年 | 696篇 |
2008年 | 867篇 |
2007年 | 897篇 |
2006年 | 831篇 |
2005年 | 797篇 |
2004年 | 758篇 |
2003年 | 724篇 |
2002年 | 741篇 |
2001年 | 584篇 |
2000年 | 533篇 |
1999年 | 464篇 |
1998年 | 164篇 |
1997年 | 120篇 |
1992年 | 267篇 |
1991年 | 231篇 |
1990年 | 236篇 |
1989年 | 218篇 |
1988年 | 212篇 |
1987年 | 203篇 |
1986年 | 223篇 |
1985年 | 191篇 |
1984年 | 160篇 |
1983年 | 136篇 |
1979年 | 192篇 |
1978年 | 125篇 |
1976年 | 116篇 |
1975年 | 155篇 |
1974年 | 180篇 |
1973年 | 170篇 |
1972年 | 159篇 |
1971年 | 150篇 |
1970年 | 169篇 |
1969年 | 151篇 |
1968年 | 172篇 |
1967年 | 173篇 |
1966年 | 137篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Irmak Karaca Suzan Güven Yılmaz Melis Palamar Halil Ateş 《Ocular immunology and inflammation》2020,28(6):947-951
ABSTRACT
Purpose
To investigate the effect of 1% tropicamide on anterior chamber aqueous flare (ACAF) measurements acquired with laser flare meter in patients with pseudoexfoliation. 相似文献2.
3.
Purpose. To present a model-dependent approach for the assessment of the in vivo drug dissolution profile based on in vitrodata for the multiple unit dosage form, as an alternative to the numerical method proposed in the study by Hayashi et al, Pharm. Res. 12:1333–1337 (1995).
Methods. The data for aspirin granules administered to healthy subjects obtained in the above mentioned study were re-evaluated. The subject dissolution system was considered to consist of two subsystems connected in series, i.e. the subsystem describing the gastric-emptying process and the subsystem describing the intestinal dissolution process. The frequency response method was used to model the subject dissolution system.
Results. The model in vivodissolution profile of aspirin, assessed as the integral of the model weighting function of the subject dissolution system, was in agreement with the in vivo cumulative absorption profile calculated by the Wagner-Nelson method.
Conclusions. Comparison of dynamic properties of the subject dissolution system with the subsystem describing the gastric-emptying process yielded quantitative confirmation of the decisive role of the gastric-emptying process in the in vivodrug dissolution after administration in the multi unit dosage form. 相似文献
4.
The present authors investigated the excretion, distribution and pharmacokinetics of the novel potential antirheumatic agent flobufen and its active metabolite after p.o. and i.v. doses of 2, 10 and 50 mg/kg administered to rats. The drug is resorbed well from the digestive tract and mostly it is metabolized to the principal metabolite M, which is only slowly excreted from the organism mainly by renal clearance. Within the whole dose range the kinetics of the drug is linear. Binding of flobufen and M to proteins is high (95-99%). The highest concentrations of radioactive metabolites (mostly M) were found in the plasma, liver, lungs, kidneys, connective tissue and inflammatory foci. The penetration of metabolites through the placenta and excretion in human milk are relatively important. 相似文献
5.
Dependence of blood clot lysis on the mode of transport of urokinase into the clot--a magnetic resonance imaging study in vitro 总被引:4,自引:0,他引:4
A Blinc G Planinsic D Keber O Jarh G Lahajnar A Zidans?k F Demsar 《Thrombosis and haemostasis》1991,65(5):549-552
Magnetic resonance imaging was employed to study the dependence of clot lysing patterns on two different modes of transport of urokinase into whole blood clots. In one group of clots (nonperfused clots, n1 = 10), access of urokinase to the fibrin network was possible by diffusion only, whereas in the other group (perfused clots, n2 = 10) bulk flow of plasma containing urokinase was instituted through occlusive clots by a pressure difference of 3.7 kPa (37 cm H2O) across 3 cm long clots with a diameter of 4 mm. It was determined separately that this pressure difference resulted in a volume flow rate of 5.05 +/- 2.4 x 10(-2) ml/min through occlusive clots. Perfused clots diminished in size significantly in comparison to nonperfused ones already after 20 min (p less than 0.005). Linear regression analysis of two-dimensional clot sizes measured by MRI showed that the rate of lysis was more than 50-times faster in the perfused group in comparison to the nonperfused group. It was concluded that penetration of the thrombolytic agent into clots by perfusion is much more effective than by diffusion. Our results might have some implications for understanding the differences in lysis of arterial and venous thrombi. 相似文献
6.
Serum digoxin-like factor was detected in infants of diabetic mothers who were insulin-dependent or diet controlled. No statistical difference was found between the serum digoxin-like factor levels of the infants of diabetic mothers and the controls. 相似文献
7.
Esra Baltacio?lu Ferda Alev Akalin Eda Topalo?lu Erkan Süküro?lu Umit Cobano?lu 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(6):803-808
Ligneous periodontitis (LP) is a rare periodontal disease in which plasminogen deficiency and fibrin deposition both play a part, resulting in characteristic gingival enlargement and periodontal breakdown. Recent data suggest that oxidant/antioxidant changes are significant in the pathology of oral diseases. This study examines the gingival histopathology in 2 cases with LP. To examine the antioxidant (AO) status, the activity of the major AOs glutathione (GSH), catalase (CAT), and glutathione S-transferase (GST) and the malondialdehyde (MDA) levels, a product of lipid peroxidation, were measured and compared with healthy control subjects. The histopathologic examination of the gingiva revealed subepithelial fibrin accumulation and irregular extensive downward proliferation of the epithelium. Biochemical analysis showed that the CAT, GST, and MDA levels were higher in LP patients than in the control subjects, and the GSH level was lower. Our preliminary findings show that in LP, the AO capacity of the gingiva changes or decreases and lipid peroxidation increases, which suggests that oxidative stress is involved in the pathology of the periodontal breakdown observed in this disease. 相似文献
8.
9.
10.
The purpose of this study is to show the spectrum of adjacent organ invasion and to make a brief review of hepatic alveolar hydatid disease (AHD), using CT and MR imaging. We retrospectively reviewed CT and MR images of three patients with various adjacent organ invasions surgically and histologically proven to be AHD. Local invasion to right kidney and adrenal, right hemidiaphragm and lung were detected in one patient, right adrenal in another patient and gall bladder, duodenum, gastric wall and pancreas invasion in the other. AHD may rarely extend to the gall bladder, stomach, duodenum, pancreas, right adrenal and kidney, diaphragm, pleura and lung. The extension of the disease outside the liver is usually encountered in patients with large, peripherally located masses in the advanced stage of the disease. 相似文献