排序方式: 共有52条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Geetha Chittoor Rector Arya Vidya S. Farook Randy David Sobha Puppala Roy G. Resendez Blanca E. Rivera-Chavira Irene Leal-Berumen Roberto Zenteno-Cuevas Juan Carlos López-Alvarenga Raul A. Bastarrachea Joanne E. Curran Subramanian Dhandayuthapani Lupe Gonzalez John Blangero Michael H. Crawford Esteban M. Vlasich Luis G. Escobedo Ravindranath Duggirala 《Tuberculosis (Edinburgh, Scotland)》2013
5.
Impact of induction immunosuppression on survival in heart transplant recipients: a contemporary analysis of agents 下载免费PDF全文
6.
7.
8.
9.
Analysis of mutations within the 5' untranslated region, interferon sensitivity region, and PePHD region as a function of response to interferon therapy in hepatitis C virus-infected patients in India 总被引:1,自引:0,他引:1 下载免费PDF全文
Gupta R Subramani M Khaja MN Madhavi C Roy S Habibullah CM Das S 《Journal of clinical microbiology》2006,44(3):709-715
Mutations in several subgenomic regions have been implicated in influencing response to interferon therapy; however, a comprehensive picture of Indian patients was lacking. Based on the viral load and clinical factors, 10 out of 15 patients were found to be complete responders, whereas 5 patients were nonresponders. The pretreatment viral RNA load of the patients was found to be between 5.20 and 6.13 log10 IU/ml, which eventually fell to 2.77 log10 IU/ml after 24 weeks of treatment, whereas in the case of nonresponders, the average was 5.38 log10 IU/ml. In order to study the influence of the hepatitis C virus genotype on the response to interferon therapy, the 5' untranslated region sequences of the samples were analyzed, which showed that genotype 3 patients responded better than genotype 1 patients. Additionally, the mutations in the interferon sensitivity-determining region (ISDR) of the NS5A protein and the double-stranded RNA-activated protein kinase-eukaryotic initiation factor 2 alpha phosphorylation homology domain (PePHD) of the E2 envelope protein, before and after treatment, were compared with nonresponder prototype J. Although, no clear correlation was found in the case of the mutated ISDR, some significant changes in residues were observed in the PePHD region, which could be helpful in understanding the molecular basis of resistance to therapy. Interestingly, analysis of the quasispecies variations showed a change in genotype in one sample during treatment, which might have contributed to the resistance. The results suggest that the mutations in different regions of the viral genome might have a concerted effect on the response to interferon therapy. 相似文献
10.
Firstenberg MS Crestanello JA Sai-Sudhakar CB Sirak JH Sun B 《The Annals of thoracic surgery》2008,85(5):1782-1784
Advances in imaging technology can provide a potentially more accurate, precise, and timely diagnosis. However, false-positive results, particularly when acute aortic pathology is being considered, can lead to unnecessary interventions. We present a case of a computed tomography scan that was false-positive for aortic dissection and highlight the importance of confirmatory studies. 相似文献