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P. N. Robinson A. Shaikh N. M. Sabir D. J. A. Vaughan M. Kynoch M. Hasan 《Anaesthesia》2014,69(7):707-711
The Tulip® airway is an adult, disposable, single‐sized oropharyngeal airway, that is connectable to an anaesthetic circuit. After a standardised induction of anaesthesia in 75 patients, the ease of insertion, intracuff pressure and intracuff volume were measured, as were the end‐tidal carbon dioxide levels, airway pressures and tidal volumes over three breaths. Successful first‐time insertion was achieved in 72 patients (96%, CI 88.8–99.2%) and after two attempts in 74 patients (99%, CI 92.8–100%). There was outright failure only in one patient. In 60 patients (80%, CI 72.2–90.4%), the Tulip airway provided a patent airway without additional manoeuvres, but in 14 patients, jaw thrust or head extension was necessary for airway patency. The main need for these adjuncts appeared to be an initial under‐inflation of the cuff. These promising results are consistent with recent manikin studies using this device. 相似文献
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Mohd Faizan Latif Zafar Jilani Mazhar Abbas Yasir Salam Siddiqui Aamir Bin Sabir M.K.A. Sherwani Saifullah Khalid 《中华创伤杂志(英文版)》2015,18(3):181-183
Inferior glenohumeral dislocation is the least common type of glenohumeral dislocations. It may be
associated with fractures of the adjacent bones and neurovascular compromise. It should be treated
immediately by close reduction. The associated neuropraxia usually recovers with time. Traction-counter traction method is commonly used for reduction followed by immobilization of the shoulder for three weeks. Here, we report a case of inferior glenohumeral joint dislocation with greater tuberosity fracture with transient neurovascular compromise and present a brief review of the literature. 相似文献
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Sabir Fatima R. N. Tomlinson Justine Strickland-Hodge Barry Smith Heather 《International journal of clinical pharmacy》2019,41(5):1239-1246
International Journal of Clinical Pharmacy - Background The patient transition from a hospital to a post-discharge healthcare setting has potential to disrupt continuity of medication... 相似文献
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Nakhleh N Francis R Giese RA Tian X Li Y Zariwala MA Yagi H Khalifa O Kureshi S Chatterjee B Sabol SL Swisher M Connelly PS Daniels MP Srinivasan A Kuehl K Kravitz N Burns K Sami I Omran H Barmada M Olivier K Chawla KK Leigh M Jonas R Knowles M Leatherbury L Lo CW 《Circulation》2012,125(18):2232-2242
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Sabir IN Fraser JA Cass TR Grace AA Huang CL 《Pflügers Archiv : European journal of physiology》2007,454(6):925-936
The clinically established proarrhythmic effect of bradycardia and antiarrhythmic effect of lidocaine (10 μM) were reproduced
in hypokalaemic (3.0 mM K+) Langendorff-perfused murine hearts paced over a range (80–180 ms) of baseline cycle lengths (BCLs). Action potential durations
(at 90% repolarization, APD90s), transmural conduction times and ventricular effective refractory periods (VERPs) were then determined from monophasic
action potential records obtained during a programmed electrical stimulation procedure in which extrasystolic stimuli were
interposed following regular stimuli at successively decreasing coupling intervals. A novel graphical analysis of epicardial
and endocardial, local and transmural relationships between APD90, corrected for transmural conduction time where appropriate, and VERP yielded predictions in precise agreement with the arrhythmogenic
findings obtained over the entire range of BCLs studied. Thus, in normokalaemic (5.2 mM K+) hearts a statistical analysis confirmed that all four relationships were described by straight lines of gradients not significantly
(P > 0.05) different from unity that passed through the origin and thus subtended constant critical angles, θ with the abscissa (45.8° ± 0.9°, 46.6° ± 0.5°, 47.6° ± 0.5° and 44.9° ± 0.8°, respectively). Hypokalaemia shifted all points
to the left of these reference lines, significantly (P < 0.05) increasing θ at BCLs of 80–120 ms where arrhythmic activity was not observed (∼63°, ∼54°, ∼55° and ∼58°, respectively) and further significantly
(P < 0.05) increasing θ at BCLs of 140–180 ms where arrhythmic activity was observed (∼68°, ∼60°, ∼61° and ∼65°, respectively). In contrast, the
antiarrhythmic effect of lidocaine treatment was accompanied by a significant (P < 0.05) disruption of this linear relationship and decreases in θ in both normokalaemic (∼40°, ∼33°, ∼39° and ∼41°, respectively) and hypokalaemic (∼40°, ∼44°, ∼50° and ∼48°, respectively)
hearts. This extended a previous approach that had correlated alterations in transmural repolarization gradients with arrhythmogenicity
in murine models of the congenital long QT syndrome type 3 and hypokalaemia at a single BCL. Thus, the analysis in terms of
APD90 and VERP provided a more sensitive indication of the effect of lidocaine than one only considering transmural repolarization
gradients and may be particularly applicable in physiological and pharmacological situations in which these parameters diverge. 相似文献