番泻叶在危重患者便秘治疗中的应用分析

目的探讨对于危重患者便秘治疗中采取番泻叶进行应用的临床效果分析。方法选取2017年1月—2017年12月进行治疗的危重患者共80例,按照治疗方式不同随机分为对照组与试验组,其中所选对照组患者采取常规西药进行治疗,试验组患者采取番泻叶结合西药进行治疗,观察2组患者临床疗效、首次排便、便秘严重程度评分等资料数据对比。结果根据试验数据可知,试验组患者在采取番泻叶结合西药进行治疗后临床疗效(92.50%)与对照组患者采取常规药物治疗的临床疗效(77.50%)存在统计学差异(P<0.05),所选2组患者治疗前各项数据比较不存在统计学差异(P>0.05),干预后排便间隔时间、便秘严重程度评分与便秘患者生存质量表与对照组患者数据对比后存在统计学差异(P<0.05)。结论对于危重患者采取番泻叶结合常规西药治疗,可有效提高患者临床治疗效果,大大提高患者首次排便的时间,改善排便间隔时间,保证消化道规律运行,大大减轻患者便秘严重程度的同时,有效提高患者的生活质量,有效的保护患者肠道功能,减轻肠胃压力,值得临床广泛推广实践。     

“血尿”“三问十二字”临床教学思路探讨

血尿是肾病科常见的临床表现,对于血尿的病因诊断分析在临床中不容易掌握,有漏诊的风险,因此需要系统而全面的诊断思路。我科在临床教学中总结了"三问十二字"的教学思路,收到较好的效果。三问包括第一问尿液呈现红色是否为血尿?第二问为符合血尿是否为病理状态?第三问为血尿一定是否只有肾脏疾病?通过三问来明确血尿的定义,并逐渐剖析临床非血尿、真性血尿、假性血尿、内科性血尿以及外科性血尿的意义。再通过内科性血尿的特点高度概括出"十二个字",以帮助学生区分内科性血尿及外科性血尿。通过"三问十二字"的深入浅出学习,可以将血尿复杂的诊断思路由繁入简掌握,并实践于临床。     

血清CA125,LDH,β2-MG在非霍奇金淋巴瘤诊断治疗中的意义

 目的 探讨血清CA125,LDH,β2-MG在非霍奇金淋巴瘤（NHL）诊断、治疗中的意义。方法 50例NHL患者,采用放射免疫学方法检测CA125及β2-MG,酶法检测LDH。结果 NHL患者血清CA125,LDH,β2-MG的升高与分期、分组、骨髓浸润、化疗效果、疾病的范围及恶性程度有关。结论 血清CA125,LDH,β2-MG作为NHL患者诊断、临床分期、是否骨髓浸润、疗效判定及预后的辅助指标。     

Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients

Purpose

Intermittent hypoxia training/treatment (IHT) is an emerging therapeutic approach to alleviate chronic diseases, such as diabetes. The present study investigated the effects of IHT on blood leucocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and its relationship with the changes in blood insulin level.

Methods

Seven adult healthy volunteers and 11 prediabetic patients participated in this study. A 3-week course of IHT consisted of a 40-min session of 4 cycles of 5-min 12% O₂ and 5-min room air breathing per day, 3 sessions per week for 3 weeks (i.e., total 9 sessions of IHT). Plasma insulin levels and leukocyte PDK-1 mRNA expression were determined at various time points either under fasting condition or following oral glucose tolerance test (OGTT). Correlation between the IHT-induced changes in PDK-1 mRNA and insulin or glucose levels in the same serological samples was analyzed.

Results

At pre-IHT baseline, PDK-1 mRNA expression was two times higher in prediabetes than control subjects. IHT resulted in significant augmentation in PDK-1 mRNA expression (> twofold) in prediabetes at the end of 3-week IHT and remained elevated 1 month after IHT, which was correlated with a significantly reduced insulin release and lower blood glucose after glucose loading with OGTT.

Conclusion

IHT can trigger beneficial effects in normalizing blood insulin levels in prediabetic patients under oral glucose load, which were closely correlated with an enhanced mRNA expression of PDK-1 in leukocytes. Further clinical trials are warranted to validate the utility of IHT as a non-invasive complementary therapy against diabetes-associated pathologies.

     

HPLC法测定金花消痤丸中栀子苷的含量

目的建立测定金花消痤丸中栀子苷含量的HPLC方法.方法色谱条件:Shim-Pack-C18柱,乙腈:水(15:85)为流动相,流速1.0ml·min-1,检测波长238 nm.结果栀子苷在5.17～51.7 mg·L-1浓度范围内与峰面积呈良好的线性关系(r=0.9999),平均回收率99.28%,RSD=0.64%.结论本法简便、准确、可控,可作为该产品的定量控制方法.     

Correlations between TLR polymorphisms and inflammatory bowel disease: a meta-analysis of 49 case-control studies

Immunologic Research - Recently, the roles of toll-like receptor (TLR) polymorphisms in inflammatory bowel disease (IBD) were intensively explored, with conflicting results. Therefore, we performed...     

Preparation of nanocellulose and its potential in reinforced composites: A review

Cellulose is a kind of natural polymer material, which is composed of bundle-like fibrils. By peeling the fibrils layer by layer, the size of cellulose can be nanocrystallized, and nanofibers and nanocrystals with unique and potentially useful features can be prepared. As an emerging functional polymer material, nanocellulose has become a research hotspot in the field of technology. This review discusses the preparation of nanocellulose, including the commonly used hydrolysis, oxidation, physical and environmentally friendly ionic liquid methods. The advantages and disadvantages of different methods are also compared. And the review introduced the application of nanofiberized cellulose and nanocellulose crystals in the fields of thermosetting and thermoplastics, such as polylactic acid, polypropylene, epoxy resin and so on. The critical factors in the manufacturing of nanocellulose composites and mechanical properties are discussed to provide a reference for the further application and development of nanocellulose.