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排序方式: 共有295条查询结果,搜索用时 15 毫秒
1.
As many as 136 patients (76 with Bechterew's disease, 40 with Reiter's disease and 20 with psoriatic arthritic) and 35 practically healthy persons were examined by echocardiography combined with electro-, phonocardiographic and by clinical, x-ray and laboratory methods. 62 patients were examined over time (within a period from 1 to 4 years). Echocardiography was used to study in detail the central and intracardiac hemodynamics, the status of the valvular apparatus of the heart and of the aorta. The different clinical characteristics of the disease were established to make a concrete contribution to the development of cardial pathology. The disease duration is the most significant characteristics. A long-term prospective follow-up coupled with echocardiographic examinations made over time enabled one to specify the structure of heart damage in patients suffering from Bechterew's disease, Reiter's disease and psoriatic arthritis depending on the hypothetic nature of the damage. 相似文献
2.
Clear cell ependymoma is a rare and diagnostically challenging subtype of ependymoma, whose genetic features are essentially unknown. We studied 13 clear cell ependymomas (five cases WHO grade II, eight cases WHO grade III) by comparative genomic hybridization (CGH). Chromosomal imbalances were found in 12/13 cases. The most common aberrations overall were +1q (38%), -9 (77%), -3 (31%), and -22q (23%). Clear cell ependymomas of WHO grade II were characterized by -9 (40%), whereas WHO grade III cases mainly showed +1q (63%), and +13q (25%), as well as -9 (100%), -3 (38%), and -22q (25%). In contrast to other ependymal tumors, clear cell ependymomas of WHO grade II showed fewer imbalances than WHO grade III samples (1.4 vs 3.5 per case). Although some of the implicated chromosomes have previously been shown to be involved in other ependymoma variants, the striking frequency of +1q, -9, and -3 suggests that aberrations differ between clear cell and other types of ependymomas, in particular, for loss of chromosome 9 which can be regarded as the molecular hallmark of clear cell ependymomas. 相似文献
3.
Electronic structure and magnetic properties of FeSe are calculated using the density functional approach. Due to the metallic properties, magnetic moments of the iron atoms in two nonequivalent positions in the unit cell are different from ionic values for Fe and Fe and are equal to and , making the system ferrimagnetic. The total magnetic moment for the unit cell is . Under isotropic compression, the total magnetic moment decreases non-monotonically and correlates with the non-monotonic dependence of the density of states at the Fermi level . For 7% compression, the magnetic order changes from the ferrimagnetic to the ferromagnetic. At 14% compression, the magnetic order disappears and the total magnetic moment becomes zero, leaving the system in a paramagnetic state. This compression corresponds to the pressure of 114 GPa. The magnetic ordering changes faster upon application of an isotropic external pressure due to the sizeable anisotropy of the chemical bondings in FeSe. The ferrimagnetic and paramagnetic states occur under pressures of 5.0 and 8.0 GPa, respectively. The system remains in the metallic state for all values of compression. 相似文献
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M. Y. Deng M. Sill D. Sturm D. Stichel H. Witt J. Ecker A. Wittmann J. Schittenhelm M. Ebinger M. U. Schuhmann D. Figarella-Branger E. Aronica O. Staszewski M. Preusser C. Haberler M. Lauten U. Schüller C. Hartmann M. Snuderl C. Dunham N. Jabado P. Wesseling M. Deckert K. Keyvani N. Gottardo F. Giangaspero K. von Hoff D. W. Ellison T. Pietsch C. Herold-Mende T. Milde O. Witt M. Kool A. Korshunov W. Wick A. von Deimling S. M. Pfister D. T. W. Jones F. Sahm 《Neuropathology and applied neurobiology》2020,46(5):422-430
6.
Adrian M. Dubuc Marc Remke Andrey Korshunov Paul A. Northcott Shing H. Zhan Maria Mendez-Lago Marcel Kool David T. W. Jones Alexander Unterberger A. Sorana Morrissy David Shih John Peacock Vijay Ramaswamy Adi Rolider Xin Wang Hendrik Witt Thomas Hielscher Cynthia Hawkins Rajeev Vibhakar Sidney Croul James T. Rutka William A. Weiss Steven J. M. Jones Charles G. Eberhart Marco A. Marra Stefan M. Pfister Michael D. Taylor 《Acta neuropathologica》2013,125(3):373-384
7.
The band structure and the Fermi surface of the recently discovered superconductor (EMIM)FeSe are studied within the density functional theory in the generalized gradient approximation. We show that the bands near the Fermi level are formed primarily by Fe-d orbitals. Although there is no direct contribution of EMIM orbitals to the near-Fermi level states, the presence of organic cations leads to a shift of the chemical potential. It results in the appearance of small electron pockets in the quasi-two-dimensional Fermi surface of (EMIM)FeSe. 相似文献
8.
V. A. Markevich V. A. Zosimovskii V. A. Korshunov G. B. Murzina V. L. Ézrokhi 《Neuroscience and behavioral physiology》1994,24(5):394-399
The possibility of the restoration of long-term potentiation in the CA1 region and the dentate gyrus of the hippocampus during
stimulation respectively of the dorsal raphé nuclei and locus coeruleus, with stimulus parameters inducing behavioral reactions,
was investigated in freely-behaving rats. It was demonstrated that stimulation of the locus coeruleus, which was ineffective
prior to the tetanization of the perforant path, led to the restoration of extinguished long-term posttetanic potentiation
in the dentate gyrus of the hippocampus induced by tetanization of the perforant path. Stimulation of the dorsal raphé nucleus,
which was ineffective prior to the tetanization of the Schaffer collaterals, led to the restoration of long-term posttetanic
potentiation in the CA1 region of the hippocampus induced by tetanization of the Schaffer collaterals. A mathematical model
is proposed which has made it possible to describe the restoration of long-term posttetanic potentiation on the basis of the
notion of the existence of several states of calcium/calmodulin-dependant protein kinase. The restoration of long-term potentiation
during stimulation of emotiogenic zones was examined as a model of the phenomenon of emotional reminding.
Translated from Zhurnal Vysshei Nervnoi Deyatel'nosti imeni I.P. Pavlova, Vol. 43, No. 4, pp. 770–777, July–August, 1993. 相似文献
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Juliane Rieber Marc Remke Christian Hartmann Andrey Korshunov Birgit Burkhardt Dominik Sturm Gunhild Mechtersheimer Andrea Wittmann Johann Greil Claudia Blattmann Olaf Witt Wolfgang Behnisch Marc‐Eric Halatsch Berk Orakcioglu Andreas von Deimling Peter Lichter Andreas Kulozik Stefan Pfister 《Genes, chromosomes & cancer》2009,48(7):558-568
Li–Fraumeni syndrome (LFS) represents an inherited tumor syndrome that is typically caused by germline mutations of the tumor suppressor gene TP53. TP53 dysfunction secondarily disturbs the genetic integrity of the cell. Here, we report a family with LFS harboring a germline TP53 mutation (R248W) located in the functional domain of the protein that binds to the minor groove of the DNA. In this family, tumors of the central nervous system were diagnosed as primary malignancies in all carriers of the mutation. The index patient developed an anaplastic medulloblastoma with unusual genomic profile exhibiting six distinct high‐level genomic amplifications, two of them targeting the MYCN and GLI2 genes, respectively. In an extrarenal rhabdoid tumor from the same patient, we found a novel high‐level amplification of the MYC oncogene. The father of this patient was diagnosed with myxopapillary ependymoma (WHO °I), whereas a brother died from an early relapse of a choroid plexus carcinoma. The analysis of this LFS familiy thus revealed novel oncogene amplifications as different second hits that are likely to also play a role in the pathogenesis of their sporadic counterparts. © 2009 Wiley‐Liss, Inc. 相似文献