收费全文 | 1473755篇 |
免费 | 107516篇 |
国内免费 | 11332篇 |
耳鼻咽喉 | 20774篇 |
儿科学 | 41967篇 |
妇产科学 | 40110篇 |
基础医学 | 207744篇 |
口腔科学 | 42205篇 |
临床医学 | 129392篇 |
内科学 | 281295篇 |
皮肤病学 | 31650篇 |
神经病学 | 112873篇 |
特种医学 | 58338篇 |
外国民族医学 | 500篇 |
外科学 | 221210篇 |
综合类 | 54203篇 |
现状与发展 | 35篇 |
一般理论 | 448篇 |
预防医学 | 101844篇 |
眼科学 | 34694篇 |
药学 | 116157篇 |
125篇 | |
中国医学 | 10774篇 |
肿瘤学 | 86265篇 |
2021年 | 14421篇 |
2019年 | 12600篇 |
2018年 | 16513篇 |
2017年 | 14031篇 |
2016年 | 14807篇 |
2015年 | 18048篇 |
2014年 | 24273篇 |
2013年 | 32608篇 |
2012年 | 43290篇 |
2011年 | 45779篇 |
2010年 | 28463篇 |
2009年 | 26447篇 |
2008年 | 40945篇 |
2007年 | 44074篇 |
2006年 | 43990篇 |
2005年 | 42126篇 |
2004年 | 39847篇 |
2003年 | 38709篇 |
2002年 | 37553篇 |
2001年 | 66660篇 |
2000年 | 67862篇 |
1999年 | 57722篇 |
1998年 | 16213篇 |
1997年 | 15172篇 |
1996年 | 14134篇 |
1995年 | 13365篇 |
1994年 | 12513篇 |
1992年 | 43597篇 |
1991年 | 42048篇 |
1990年 | 41228篇 |
1989年 | 40186篇 |
1988年 | 37528篇 |
1987年 | 36897篇 |
1986年 | 35353篇 |
1985年 | 33463篇 |
1984年 | 25151篇 |
1983年 | 21309篇 |
1982年 | 12907篇 |
1979年 | 24102篇 |
1978年 | 17248篇 |
1977年 | 15040篇 |
1976年 | 13567篇 |
1975年 | 15378篇 |
1974年 | 18227篇 |
1973年 | 17685篇 |
1972年 | 16910篇 |
1971年 | 15836篇 |
1970年 | 15017篇 |
1969年 | 14446篇 |
1968年 | 13548篇 |
Method: Socio-demographics, early-life adversity (ELA), individual quality of life (iQoL), and mental and physical health of 270 individuals (Mage = 66.82 years, 71.5% female) were assessed. Polynomial regressions and mediation analyses were conducted.
Results: Significant inverse U-shaped associations were found between ELA and iQoL (β = ?.59, p = .005) and between ELA and mental health (β = ?.64, p = .002), but not between ELA and physical health. Furthermore, mental health significantly mediated the relationship between ELA and iQoL (b = ?.84, BCa CI [?1.66, ?.27]).
Conclusion: Highest level of individual quality of life (i.e. successful aging) was related to a moderate amount of ELA. Additionally, mental health significantly mediated this relationship. These findings suggest that some amount of ELA could be beneficial for successful aging. Resource-focused interventions are needed to improve health and promote successful aging for an underdetected, at-risk subgroup with low early-life adversity. 相似文献
2. Firstly, cell viability and biochemical indicators were determined and the cell morphology was observed to confirm the cell injury and develop a cell hepatotoxicity model. Then, with the help of cell metabolomics based on UPLC-MS, the Genkwa Flos group samples were completely separated from the blank group samples in the score plots and seven upregulated as well as two down-regulated putative biomarkers in the loading plot were identified and confirmed. Besides, two signal molecules and four enzymes involved in biosynthesis pathway of lysophosphatidylcholine and the sphingosine kinase/sphingosine-1-phosphate pathway were determined to investigate the relationship between Genkwa Flos hepatotoxicity and these two classic pathways. Finally, the metabolic pathways related to specific biomarkers and two classic metabolic pathways were analyzed to explain the possible mechanism of Genkwa Flos hepatotoxicity.
3. Based on the results, lipid peroxidation and oxidative stress, phospholipase A2/lysophosphatidylcholine pathway, the disturbance of sphingosine-1-phosphate metabolic profile centered on sphingosine kinase/sphingosine-1-phosphate pathway and fatty acid metabolism might be critical participators in the progression of liver injury induced by Genkwa Flos. 相似文献