全文获取类型
收费全文 | 761篇 |
免费 | 50篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 14篇 |
妇产科学 | 9篇 |
基础医学 | 65篇 |
口腔科学 | 16篇 |
临床医学 | 77篇 |
内科学 | 117篇 |
皮肤病学 | 22篇 |
神经病学 | 34篇 |
特种医学 | 117篇 |
外科学 | 60篇 |
综合类 | 90篇 |
预防医学 | 25篇 |
眼科学 | 11篇 |
药学 | 114篇 |
中国医学 | 11篇 |
肿瘤学 | 58篇 |
出版年
2023年 | 5篇 |
2022年 | 8篇 |
2021年 | 18篇 |
2020年 | 13篇 |
2019年 | 21篇 |
2018年 | 17篇 |
2017年 | 16篇 |
2016年 | 18篇 |
2015年 | 23篇 |
2014年 | 15篇 |
2013年 | 28篇 |
2012年 | 44篇 |
2011年 | 37篇 |
2010年 | 28篇 |
2009年 | 29篇 |
2008年 | 41篇 |
2007年 | 48篇 |
2006年 | 32篇 |
2005年 | 26篇 |
2004年 | 14篇 |
2003年 | 18篇 |
2002年 | 11篇 |
2001年 | 11篇 |
2000年 | 15篇 |
1999年 | 19篇 |
1998年 | 34篇 |
1997年 | 24篇 |
1996年 | 22篇 |
1995年 | 21篇 |
1994年 | 21篇 |
1993年 | 17篇 |
1992年 | 3篇 |
1991年 | 7篇 |
1990年 | 6篇 |
1989年 | 16篇 |
1988年 | 16篇 |
1987年 | 13篇 |
1986年 | 12篇 |
1985年 | 6篇 |
1984年 | 11篇 |
1983年 | 11篇 |
1982年 | 6篇 |
1981年 | 10篇 |
1980年 | 10篇 |
1979年 | 3篇 |
1978年 | 6篇 |
1977年 | 4篇 |
1975年 | 7篇 |
1973年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有845条查询结果,搜索用时 31 毫秒
1.
2.
目的由于卒中风险随着狭窄严重程度的增加而升高,因此认为颈内动脉(ICA)接近闭塞患者的卒中风险很高。在现有的随机试验中,还没有专门针对这种情况进行探讨,因此其处理尚存在争汶。方法:对相关文献进行系统评价。结果:对ICA接近闭塞患者的处理还存在争议:一些学者支持进行干预,而另一些学者则认为存在风险或没有益处而反对进行干预。在ICA接近闭塞的有症状患者中进行一项比较外科治疗与最佳内科治疗的多中心前瞻性随机试验似乎非常困难,因为这类研究需要大量的患者。尽管如此,基于目前的证据,似乎很难拒绝手术治疗。结论:由于目前对ICA接近闭塞患者的最佳处理方案仍存在着争议,因此需要前瞻性观察性研究以证实其在有症状和无症状人群中的患病率以及相关的卒中风险。基于目前的证据,大多数医疗中心选择手术治疗,但它相对干内科治疗的特粱尚右待证章. 相似文献
3.
4.
5.
Rupture of the distal biceps tendon: evaluation with MR imaging 总被引:2,自引:0,他引:2
6.
A. Chan R. Shinde C. C. Chow C. S. Cockram R. Swaminathan 《Clinical endocrinology》1994,41(2):213-216
OBJECTIVE Thyrotoxic periodic paralysis (TPP) usually follows a heavy carbohydrate meal and this may be explained by hyperinsulinaemia stimulating Na+, K+ -ATPase activity. To clarify this the effect of glucose load on serum insulin concentration and platelet Na+, K+ -ATPase activity In thyrotoxic periodic paralysis (TPP) was examined. DESIGN In all subjects a standard 75-g glucose tolerance test was done and blood samples were taken at 0, 1 and 2 hours. SUBJECTS Twenty-five healthy controls (8 M and 17 F), 17 uncomplicated thyrotoxic patients (7M and 10 F), 15 TPP patients who presented with paralysis and 4 TPP patients after treatment with antithyrold drugs. MEASUREMENTS Plasma glucose was measured by the glucose oxidase method, serum insulin by radioimmunoassay and platelet Na+, K+ -ATPase by the release of phosphate from ATP. RESULTS TPP patients showed glucose intolerance (area under the curve (AUC) 16·5 ± 4·4 (mean ± SD) In TPP compared to 12·9 ± 4·5 In controls (P < 0·01) and hyperinsulinaemia (AUC 189·6 ±100·6 vs 98·5 ±53·4, P < 0·001). In uncomplicated thyrotoxicosis the results were similar to that in healthy controls. Platelet Na+, K+ -ATPase were significantly higher in thyrotoxic patients compared to controls and In TPP patients were even higher. Ingestion of glucose increased platelet Na+, K+ -ATPase in all groups. AUC for platelet Na+, K+ -ATPase in TPP patients were significantly higher than in uncomplicated thyrotoxicosis (601 ±99·3 vs 482 ± 109·4, P < 0·01) or healthy controls (320 ± 107·3). In the 4 TPP patients studied after antithyroid treatment the results were similar to healthy controls. CONCLUSION Patients with thyrotoxic periodic paralysis have hyperinsulinaemia and this is accompanied by higher Na+, K+-ATPase activity. 相似文献
7.
8.
Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability 总被引:1,自引:15,他引:1
La Spada AR; Peterson KR; Meadows SA; McClain ME; Jeng G; Chmelar RS; Haugen HA; Chen K; Singer MJ; Moore D; Trask BJ; Fischbeck KH; Clegg CH; McKnight GS 《Human molecular genetics》1998,7(6):959-967
X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a CAG
repeat expansion in the first exon of the androgen receptor (AR) gene.
Disease-associated alleles (37-66 CAGs) change in length when transmitted
from parents to offspring, with a significantly greater tendency to shift
size when inherited paternally. As transgenic mice carrying human AR cDNAs
with 45 and 66 CAG repeats do not display repeat instability, we attempted
to model trinucleotide repeat instability by generating transgenic mice
with yeast artificial chromosomes (YACs) carrying AR CAG repeat expansions
in their genomic context. Studies of independent lines of AR YAC transgenic
mice with CAG 45 alleles reveal intergenerational instability at an overall
rate of approximately 10%. We also find that the 45 CAG repeat tracts are
significantly more unstable with maternal transmission and as the
transmitting mother ages. Of all the CAG/CTG repeat transgenic mice
produced to date the AR YAC CAG 45 mice are unstable with the smallest
trinucleotide repeat mutations, suggesting that the length threshold for
repeat instability in the mouse may be lowered by including the appropriate
flanking human DNA sequences. By sequence-tagged site content analysis and
long range mapping we determined that one unstable transgenic line has
integrated an approximately 70 kb segment of the AR locus due to
fragmentation of the AR YAC. Identification of the cis - acting elements
that permit CAG tract instability and the trans -acting factors that
modulate repeat instability in the AR YAC CAG 45 mice may provide insights
into the molecular basis of trinucleotide repeat instability in humans.
相似文献
9.
10.