全文获取类型
收费全文 | 555篇 |
免费 | 29篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 40篇 |
妇产科学 | 14篇 |
基础医学 | 43篇 |
口腔科学 | 11篇 |
临床医学 | 39篇 |
内科学 | 101篇 |
皮肤病学 | 7篇 |
神经病学 | 38篇 |
特种医学 | 96篇 |
外科学 | 52篇 |
综合类 | 61篇 |
预防医学 | 16篇 |
眼科学 | 11篇 |
药学 | 28篇 |
中国医学 | 1篇 |
肿瘤学 | 26篇 |
出版年
2022年 | 9篇 |
2021年 | 13篇 |
2020年 | 6篇 |
2019年 | 3篇 |
2018年 | 9篇 |
2017年 | 8篇 |
2016年 | 8篇 |
2015年 | 16篇 |
2014年 | 6篇 |
2013年 | 11篇 |
2012年 | 18篇 |
2011年 | 18篇 |
2010年 | 22篇 |
2009年 | 17篇 |
2008年 | 26篇 |
2007年 | 17篇 |
2006年 | 20篇 |
2005年 | 21篇 |
2004年 | 10篇 |
2003年 | 13篇 |
2002年 | 18篇 |
2001年 | 15篇 |
2000年 | 11篇 |
1999年 | 13篇 |
1998年 | 30篇 |
1997年 | 25篇 |
1996年 | 19篇 |
1995年 | 17篇 |
1994年 | 13篇 |
1993年 | 9篇 |
1992年 | 6篇 |
1990年 | 4篇 |
1989年 | 17篇 |
1988年 | 17篇 |
1987年 | 18篇 |
1986年 | 15篇 |
1985年 | 7篇 |
1984年 | 6篇 |
1983年 | 6篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1976年 | 4篇 |
1975年 | 14篇 |
1974年 | 3篇 |
1969年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有588条查询结果,搜索用时 312 毫秒
1.
2.
The purpose of this study is to show the spectrum of adjacent organ invasion and to make a brief review of hepatic alveolar hydatid disease (AHD), using CT and MR imaging. We retrospectively reviewed CT and MR images of three patients with various adjacent organ invasions surgically and histologically proven to be AHD. Local invasion to right kidney and adrenal, right hemidiaphragm and lung were detected in one patient, right adrenal in another patient and gall bladder, duodenum, gastric wall and pancreas invasion in the other. AHD may rarely extend to the gall bladder, stomach, duodenum, pancreas, right adrenal and kidney, diaphragm, pleura and lung. The extension of the disease outside the liver is usually encountered in patients with large, peripherally located masses in the advanced stage of the disease. 相似文献
3.
4.
G. Mazzocchi P. Rebuffat C. Robba A. S. Belloni A. Stachowiak G. Gottardo V. Meneghelli G. G. Nussdorfer 《Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie》1987,187(4):251-263
The effects of metoclopramide (MTC) and bromocriptine (BRC) (two drugs which act as antagonist and agonist of DOPA-receptors, respectively) on the zona glomerulosa of dexamethasone/ACTH-treated rats were investigated by coupled biochemical and morphometric techniques. Short-term (1-h) MTC administration significantly increased the plasma concentration of aldosterone, while long-term (7-day) MTC administration, as well as short- and long-term treatment with BRC did not cause any apparent change. Long-term MTC administration was found to significantly potentiate both the rise in the plasma level of aldosterone and the hypertrophy of the zona glomerulosa and its parenchymal cells induced by a prolonged treatment with angiotensin II (AII), but not those evoked by a chronic sodium deprivation alone or combined with AII infusion. Long-term BRC administration notably counteracted the effects of sodium restriction (coupled or not with AII infusion), but not those induced by the administration of AII alone. Long-term MTC administration partially reversed both the lowering of the plasma concentration of aldosterone and the atrophy of the zona glomerulosa and its parenchymal cells caused by a prolonged sodium-loading (combined or not with captopril infusion), but not those produced by the administration of captopril alone. On the other hand, long-term BRC treatment induced a further significant reduction in the blood level of aldosterone and the volume of zona glomerulosa and its cells only in captopril-treated animals. These findings are consistent with the view that the dopaminergic system exerts a maximal tonic inhibitory effect not only on the secretory activity, but also on the growth and steroidogenic capacity of the rat zona glomerulosa. Furthermore, they suggest that the activity of the dopaminergic system is in turn controlled by the sodium balance, being almost completely suppressed by a prolonged sodium deprivation. 相似文献
5.
C McKenzie BAppSc P Megaw BAppSc I Morgan PhD MK Boelen PhD 《Clinical & experimental ophthalmology》1997,25(4):79-81
Deprivation of form vision by the fitting of translucent occluders suppressed the diurnal cycling of enkephalinergic amacrine cells (the ENSLI amacrine cells), in the chicken. Daily periods of normal vision or enforcing temporal contrast using strobe lighting appeared to restore normal functioning of the ENSLI cells. These results suggest that the ENSLI cells are involved in retinal circuits that assess the quality of the visual image and control eye growth. 相似文献
6.
7.
8.
9.
10.
Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP) 总被引:8,自引:0,他引:8
Rowe PS; Oudet CL; Francis F; Sinding C; Pannetier S; Econs MJ; Strom TM; Meitinger T; Garabedian M; David A; Macher MA; Questiaux E; Popowska E; Pronicka E; Read AP; Mokrzycki A; Glorieux FH; Drezner MK; Hanauer A; Lehrach H; Goulding JN; O'Riordan JL 《Human molecular genetics》1997,6(4):539-549
Mutations in the PEX gene at Xp22.1 (phosphate-regulating gene with
homologies to endopeptidases, on the X-chromosome), are responsible for
X-linked hypophosphataemic rickets (HYP). Homology of PEX to the M13 family
of Zn2+ metallopeptidases which include neprilysin (NEP) as prototype, has
raised important questions regarding PEX function at the molecular level.
The aim of this study was to analyse 99 HYP families for PEX gene
mutations, and to correlate predicted changes in the protein structure with
Zn2+ metallopeptidase gene function. Primers flanking 22 characterised
exons were used to amplify DNA by PCR, and SSCP was then used to screen for
mutations. Deletions, insertions, nonsense mutations, stop codons and
splice mutations occurred in 83% of families screened for in all 22 exons,
and 51% of a separate set of families screened in 17 PEX gene exons.
Missense mutations in four regions of the gene were informative regarding
function, with one mutation in the Zn2+-binding site predicted to alter
substrate enzyme interaction and catalysis. Computer analysis of the
remaining mutations predicted changes in secondary structure,
N-glycosylation, protein phosphorylation and catalytic site molecular
structure. The wide range of mutations that align with regions required for
protease activity in NEP suggests that PEX also functions as a protease,
and may act by processing factor(s) involved in bone mineral metabolism.
相似文献