全文获取类型
收费全文 | 424篇 |
免费 | 33篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 31篇 |
妇产科学 | 18篇 |
基础医学 | 30篇 |
口腔科学 | 16篇 |
临床医学 | 51篇 |
内科学 | 102篇 |
皮肤病学 | 14篇 |
神经病学 | 12篇 |
特种医学 | 3篇 |
外科学 | 51篇 |
综合类 | 46篇 |
一般理论 | 2篇 |
预防医学 | 37篇 |
眼科学 | 3篇 |
药学 | 38篇 |
中国医学 | 1篇 |
肿瘤学 | 3篇 |
出版年
2017年 | 6篇 |
2015年 | 9篇 |
2014年 | 6篇 |
2013年 | 9篇 |
2012年 | 4篇 |
2011年 | 5篇 |
2010年 | 5篇 |
2009年 | 14篇 |
2008年 | 5篇 |
2006年 | 9篇 |
2002年 | 6篇 |
2001年 | 5篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 6篇 |
1997年 | 14篇 |
1996年 | 11篇 |
1995年 | 10篇 |
1994年 | 10篇 |
1993年 | 10篇 |
1992年 | 12篇 |
1991年 | 9篇 |
1990年 | 8篇 |
1989年 | 7篇 |
1988年 | 5篇 |
1987年 | 8篇 |
1986年 | 9篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1983年 | 13篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1977年 | 5篇 |
1976年 | 7篇 |
1974年 | 5篇 |
1971年 | 6篇 |
1969年 | 4篇 |
1966年 | 4篇 |
1964年 | 3篇 |
1963年 | 3篇 |
1960年 | 3篇 |
1959年 | 15篇 |
1958年 | 20篇 |
1957年 | 26篇 |
1956年 | 18篇 |
1955年 | 27篇 |
1954年 | 12篇 |
1949年 | 3篇 |
排序方式: 共有458条查询结果,搜索用时 15 毫秒
1.
2.
Adoption studies have led to the suggestion that there may be two distinct subgroups of alcoholics with differing genetic contributions. Among 249 male alcoholics we used discriminant analysis to relate the features of type 1 and type 2 alcoholism it the presence or absence of a family history of alcoholism in male paternal relatives. We found that guilt and hinging, features usually attributed to type 1 (milieu-limited) alcoholism, were in fact more prevalent m the family history positive group. An additional cohort analysis found cohort-related variations in type 1/type 2 characteristics. The possible implications of these findings are discussed. 相似文献
3.
BELIN VINCENT; HODGE THOMAS; PICAUT PHILIPPE; JORDAN ROY; ALGATE CAROL; GOSSELIN SYLVIE; NOHYNEK GERHARD; CAVERO ICILIO 《Toxicological sciences》1996,31(2):259-267
Aprikalim is a potent, specific, and selective opener of ATP-sensitiveK+ (KATP) channels. By virtue of this pharmacological property,aprikalim affords cardioprotection in experimental models ofischemia/reperfusion injury, and, at higher doses, also causesperipheral or coronary vasodilatation. Direct-acting peripheralvasodilators can cause myocardial lesions, particularly in ratsand dogs. However, unexpectedly, aprikalim produced this effectalso in monkeys. Thus, the primary aim of this investigationwas to assess whether in monkeys these myocardial lesions werethe direct or indirect consequence of the vascular effects ofaprikalim. Cyno-mologus monkeys were given the ß-adrenoceptorantagonist nado-lol (2 mg/kg po, twice daily) for 4 consecutivedays. On the third and fourth day of the experiment, they receivedaprikalim (1 mg/kg po). In another series, two monkeys carryingtelemetry transmitters for blood pressure and heart rate measurementswere also given aprikalim or its vehicle. Finally, aprikalim(1 mg/kg po for 2 days) or its vehicle was administered to ratswhich were concurrently treated with the ß-adrenoceptorantagonist atenolol (5 mg/ kg sc) or its vehicle. In cynomologusmonkeys, aprikalim produced focal and multifocal myocardialnecrosis of minimal to moderate intensity in or near the papillarymuscles of the left ventricle. These effects were abrogatedby nadolol. Similarly, necrotic lesions were caused by aprikalimonly in those rats which had not been pretreated with atenolol.In monkeys, aprikalim produced a marked and long-lasting decreasein aortic blood pressure, accompanied by an even more prolongedtachycardia. These results demonstrate that aprikalim can producemyocardial necrosis not only in rats but also in monkeys. Toour knowledge, this is the first time that such adverse effectsare reported for a vasodilator in monkeys. More importantly,these effects were prevented by blocking cardiac ß-adrenoceptors.Thus, the myocardial lesions produced by aprikalim may be attributedto its profound and prolonged hemodynamic effects. 相似文献
4.
A Comparison of Women and Men Undergoing Catheter Ablation for Sustained Monomorphic Ventricular Tachycardia 下载免费PDF全文
5.
Comparison of Complete and Incomplete Revascularization by Coronary Angioplasty for Unstable Angina 总被引:1,自引:0,他引:1
ROY S. SMALL M.D. DAVID R. HOLMES Jr M.D. RONALD E. VLIETSTRA M.B. Ch.B. GUY S. REEDER M.D. JOHN F. BRESNAHAN M.D. DENNIS R. BRESNAHAN M. D. 《Journal of interventional cardiology》1988,1(1):11-17
When a "culprit lesion" can be identified in a patient with unstable angina, it may be possible to achieve clinical improvement with incomplete revascularization. We analyzed actuarial survival free of an event (severe angina, myocardial infarction, coronary artery bypass graft, or death) at 6, 12, 18, and 24 months in 83 patients with multi-vessel disease and unstable angina who had undergone successful percutaneous transluminal coronary angioplasty (PTCA); revascularization was complete in 31 patients and incomplete in 52. Event-free survival in 85 patients with single-vessel disease and unstable angina who had undergone successful PTCA also was analyzed. Event-free survival at 24 months was worse in the multivessel disease patients than in the single-vessel disease patients (62% vs 85%; P = 0.001). Multivessel disease patients with complete revascularization had the same event-free survival as those with incomplete revascularization (63% vs 61%; P NS). Diagnostic angiograms revealed thrombus or an irregular ulcerated lesion in 42 of the multivessel disease patients. The event-free survival of these 42 patients was not different from that of the multivessel disease patients as a whole (64% vs 60%; P NS). We conclude that in patients with multivessel disease and unstable angina the event-free survival after PTCA is poorer than in patients with single-vessel disease and unstable angina. In the former patients, event-free survival does not necessarily depend on the completeness of revascularization. The outcome of patients who have intra-coronary thrombus or an irregular ulcerated lesion resembles the outcome of patients who lack these findings. (J Interven Cardiol: 1988:1:1) 相似文献
6.
7.
Nesidioblastosis is a disorder which is characterized by autonomous insulin secretion that is not affected by decreases in blood glucose. Patients usually present during the neonatal or infantile period with hypoglycaemia associated with hyperinsulinaemia. Most cases of nesidioblastosis are sporadic; however, familial forms appear to be inherited in an autosomal recessive manner. We discuss the anaesthetic management of a patient with nesidioblastosis who presented for near total pancreatectomy and review the literature pertinent to the anaesthesiologist. 相似文献
8.
9.
The importance of “double tourniquet” technique in repair of the quadriceps mechanism after total patellectomy in recent fractures of the patella is described and its advantages are discussed. The results following this method of repair in 17 total patellectomies have been studied and discussed. 相似文献
10.
A case of a severe immediate-type respiratory reaction to rattlesnake venom is reported. Reaginic antibody to the snake venom was demonstrated in the patient's serum by long latency passive cutaneous anaphylaxis in a monkey. IgE antibody against the venom was demonstrated in the patient's serum by a solid phase radioimmunoassay. This report confirms the immediate-type respiratory reactions that have been observed by others. The study also confirms that these reactions are associated with reaginic antibodies against the venom and that these antibodies are probably of the IgE class. It thus appears most likely that this patient's reaction was due to IgE reaginic antibody. In vitro assays for specific IgE activity may be particularly valuable in cases where antigen may be toxic for skin testing. 相似文献