2017年全球新药研发报告——第二部分：趋势与挑战（Ⅶ）

通过敏锐的视角概述了2017年全球制药行业热点话题,包括影响美国和其他一些发达国家的日益严重的阿片类药物危机,2017—2018年的流感疫情,并聚焦通用流感疫苗的需求。与往年一样,报告对孤儿药开发、优先药物（PRIMW）和再生医学先进疗法（RMAT）等新支持政策、研发管线减缩、药品定价以及值得关注的制药/生物技术公司间的兼并与收购交易进行了回顾;此外,还预测了2018年将会通过审批的新药。

     

连续性半侧颅痛的神经-眼科表现

目的:本文描述了一组对消炎痛有效的连续性半侧颅痛患者一种罕见的原发性头痛综合征,用神经-眼科学检查评估患者的临床表现。设计:观察性病例研究。方法:9例年龄在29～58岁的患者具有神经-眼科方面各种症状,并存在单侧持续性头痛表现。收集每例患者的详细病史,进行眼科学和神经     

对各种程度近视眼施行激光原位角膜磨镶术的5年随访

目的:评价接受激光原位角膜磨镶术(LASIK)患者的远期屈光和视力状况。方法:本文是一项针对1998—1999年间接受LASIK手术患者的视力及屈光情况的回顾性研究。对49例各种近视屈光程度的患者纳入本研究进行随访。主要观察指标:安全性、有效性、可预测性以及稳定性,同时记录了术后并发症及屈光的偏差情况。平均术前等量球镜值为-4.85。结果:术后2个月时,67%的患眼在可矫正的±0.5D,81%的患眼在±1.0D。术后5年时,60%的患眼在可矫正的±0.5D,83%在±1.0D。88%的患眼术后2个月时视力为≥6/12,而术后5年时这一比例达到89%。51%的患者最佳镜片…     

Relationship between apolipoprotein E, D10S1225 poly- morphisms and late-onset Alzheimer''s disease

Alzheimer’s disease (AD) is the most common neurodegenerative disorder disease, which is the leading cause of dementia in the elderly population. Pathologically, AD is characterized by neurofibrillary tangles found in the neurons of the cerebral cortex and hippocampus, the deposition of amyloid within senile plaques and cerebral blood vessels, and the loss of neuron and synapses. Clinically, AD is slowly progressive, leading to memory loss; alteration of higher intellectual function and cog…     

Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics

Accurate diagnosis of predominantly colonic inflammatory bowel disease(IBD) is not possible in 30% of patients. For decades, scientists have worked to find a solution to improve diagnostic accuracy for IBD, encompassing Crohn’s colitis and ulcerative colitis. Evaluating protein patterns in surgical pathology colectomy specimens of colonic mucosal and submucosal compartments, individually, has potential for diagnostic medicine by identifying integrally independent, phenotype-specific cellular and molecular characteristics. Mass spectrometry(MS) and imaging(I) MS are analytical technologies that directly measure molecular species in clinical specimens, contributing to the in-depth understanding of biological molecules. The biometric-system complexity and functional diversity is well suited to proteomic and diagnostic studies. The direct analysis of cells and tissues by Matrix-Assisted-Laser Desorption/Ionization (MALDI) MS/IMS has relevant medical diagnostic potential. MALDI-MS/IMS detection generates molecular signatures obtained from specific cell types within tissue sections. Herein discussed is a perspective on the use of MALDI-MS/IMS and bioinformatics technologies for detection of molecular-biometric patterns and identification of differentiating proteins. I also discuss a perspective on the global challenge of transferring technologies to clinical laboratories dealing with IBD issues. The significance of serologic-immunometric advances is also discussed.     

Association of creatine kinase with Alzheimer’s disease pathology: A cross-sectional study

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Regulated cell death in cancer: from pathogenesis to treatment

Regulated cell death (RCD), including apoptosis, pyroptosis, necroptosis, and ferroptosis, is regulated by a series of evolutionarily conserved pathways, and is required for development and tissue homeostasis. Based on previous genetic and biochemical explorations of cell death subroutines, the characteristics of each are generally considered distinctive. However, recent in-depth studies noted the presence of crosstalk between the different forms of RCD; hence, the concept of PANoptosis appeared...     

《温热论》与《伤寒论》卫气营血理论差异性研究

《温热论》中营卫和气血,用于论述机体的生理功能、病理变化时,与《伤寒论》相似。然而,《温热论》所创立的温病卫气营血辨证论治体系,与《伤寒论》有明显的差异,具体表现在致病因素、感邪途径、初起病位、传变方式及治法等方面。《温热论》所载温病卫气营血不同阶段治疗方法为邪袭肺卫宜辛凉解表,邪留三焦需分消上下,邪阻阳明当轻法频下,邪困脾胃要利尿通阳,与《伤寒论》大异。     

《温疫论》阳气郁滞理论及其对新型冠状病毒肺炎防治的启示

《温疫论》系统地阐述了温疫阳气郁滞的病机、证候、治疗禁忌、辨证论治及自愈候等内容,对于新型冠状病毒肺炎(以下简称“新冠肺炎”)的防治,具有重要的参考价值。吴又可提出阳气郁滞证的治疗禁忌有禁辛温发汗、禁过用寒凉、禁补气等,并列举了阳气郁滞自愈候,这些内容对新冠肺炎的防控有一定指导意义;辨证论治主要有膜原阳气郁滞证、表里阳气郁滞证、胃家阳气郁滞证、阴虚阳气郁滞证、阴络阳气郁滞证等,涉及疏利透达、三消、攻下、养阴、通络等各种针对温疫不同阶段阳气郁滞的通阳治法。《温疫论》阳气郁滞理论,不仅较好地阐释了新冠肺炎各阶段的病机特点,而且为其治疗提供中医临床思路,主要体现在新冠肺炎的全程治疗、分期论治、因地制宜等方面,均要注意祛邪通阳。     

张喜奎教授治疗糖尿病肾病经验浅析

张喜奎教授运用六经辨证,将糖尿病肾病分为常见的少阴阴虚证、少阴阴虚　太阴气虚证、少阴阴阳两虚证、少阴阳虚水泛证、厥阴阳衰　浊瘀互结证等五型,分别运用六味地黄汤合二至丸、黄芪二至丸、金匮肾气丸、真武汤及大黄附子汤随证加减,取得了较好的临床疗效,现将张师治疗糖尿病肾病的经验总结如下,为临床辨治该病提供参考。